The association between Toll-like receptor 2 single-nucleotide polymorphisms and hepatocellular carcinoma susceptibility

Xie, Jin; Jiang, Songyao; Shi, Minmin; Song, Yingliang; Shen, Baiyong; Deng, Xiaxing; Jin, Jianhua; Xi, Zhan; Chen, Hao

doi:10.1186/1471-2407-12-57

Cited by 63 publications

(53 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have shown that TLR-9 engagement on cluster of differentiation 4-positive (CD4 + ) T cells can enhance their survival and therefore potentiate anticancer responses by prolonging T-cell activity 14. Previous studies have indicated that TLR-9 polymorphisms may be associated with the risk of developing several types of cancers, including bladder cancer,15 prostate cancer,16–18 acute lymphoblastic leukemia,19 hepatocellular carcinoma,20 gastric cancer,21,22 cervical cancer,23 Hodgkin’s lymphoma,24 breast cancer,25 Burkitt’s lymphoma,26 non-Hodgkin’s lymphoma,27 endometrial cancer,28 esophageal cancer,23 and lymphoma 24,27,29. However, the results are inconsistent and inconclusive.…”

Section: Introductionmentioning

confidence: 99%

Association between TLR-9 polymorphisms and colon cancer susceptibility in Saudi Arabian female patients

Semlali

Parine

Amri

et al. 2016

OTT

View full text Add to dashboard Cite

ObjectiveThe authors aimed to explore the relationship between the expression/polymorphisms of TLR-9 and susceptibility to colon cancer development in the Saudi Arabian population.MethodsIn total, blood samples from 115 patients with colon cancer and 102 participants without colon cancer were analyzed in this study. Three single-nucleotide polymorphisms (SNPs) were selected from the TLR-9 gene, including two sites within the TLR-9 gene’s promoter region (rs352144 and rs187084) and one site in a TLR-9 intron region (rs5743839). Odds ratios (ORs) and 95% confidence intervals (CIs) were computed from logistic regression models after adjusting for age, gender, and tumor localization. To investigate the differential expression of TLR-9 in colon cancer, TLR-9 expression was evaluated using quantitative real-time reverse transcription polymerase chain reaction on 40 matched normal and colon tissues.ResultsThe authors found that TLR-9 expression was decreased in colon cancer tissues as compared with that in normal tissues. Moreover, significant associations between the TLR-9 rs187084 SNP and colon cancer risk were observed in female patients only. In rs187084, the T allele had a significantly lower frequency (2.8 times) in female cancer patients than in controls (0.27 vs 0.41). The TLR-9 rs352139 and rs352144 SNPs were significantly associated with colon cancer development when the tumor was located in the rectal area.ConclusionThe findings support the hypothesis that TLR-9 has an anticancer role in colon cancer development. Furthermore, genetic variation may influence colon cancer development, and SNPs in TLR-9 could serve as biomarkers for decision making in the treatment of females with rectal cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Association between TLR-9 polymorphisms and colon cancer susceptibility in Saudi Arabian female patients

Semlali

Parine

Amri

et al. 2016

OTT

View full text Add to dashboard Cite

show abstract

“…This downregulation occurs because of the SNPs, epigenetic changes, or microRNA modifications. Previous studies have shown that genetic variations in TLR2, particularly those arising from polymorphisms, are often linked to different infectious diseases 27. The present study investigated whether polymorphisms of TLR2 are associated with the development of BC among women in the Kingdom of Saudi Arabia, to enable identification of markers for diagnosis and treatment.…”

Section: Discussionmentioning

confidence: 97%

No genetic relationship between TLR2 rs4696480, rs3804100, and rs3804099 gene polymorphisms and female breast cancer in Saudi populations

Semlali¹,

Almutairi²,

Parine³

et al. 2017

OTT

View full text Add to dashboard Cite

Breast cancer (BC) is the most common cause of cancer-related deaths among women in the Kingdom of Saudi Arabia. An association between the dysregulation of innate immunity, primarily the deregulation of Toll-like receptors (TLRs), and BC development was described a long time ago. Several studies have reported that BC risk factors appear to be related to the interaction between certain genes and exposure to various environmental factors. Here, we investigated the potential correlation of three TLR2 single-nucleotide polymorphisms (SNPs; rs3804100, rs4696480, and rs3804099) with the development of BC in female patients from Saudi Arabia. We collected 126 blood samples from women with BC and 146 blood samples from healthy women without any clinical signs of BC. The genotypic frequencies of TLR2 polymorphisms were assayed. Our results showed that the genotypic and allelic frequencies of TLR2 did not differ significantly between BC patients and healthy controls. However, the distributions of rs3804100 (1350 T/C) genotypes in BC groups were 1%, 19%, and 80% for CC, CT, and TT, respectively. In the control group, the rs3804100 (1350 T/C) genotype distributions were 3%, 18%, and 79% for CC, CT, and TT, respectively. The SNP rs3804100 homozygous “TT” genotype was not associated with the risk of developing BC in the BC patients compared with controls (odds ratio [OR], 4.5; confidence interval [CI], 0.49–41.02; P=0.145). The TLR2 rs4696480 AA genotype was observed in 23% of BC patients compared to 18% of control individuals, the AT genotype was seen in 40% of BC patients and 46% of control individuals, and the TT genotype was observed in 37% of BC patients and 36% of normal controls. Our results did not show any difference in genotypic frequency between BC patients and normal controls for the TLR2 rs3804099 SNP; however, the (C) phenotypic frequency was 49% in BC patients and 53% in controls. The (T) phenotypic frequency was 51% and 47% in BC patients and normal patients, respectively. These findings indicate that there is no association between the TLR2 polymorphisms tested and BC susceptibility in the female population from the Kingdom of Saudi Arabia. We suggest using other TLR2 SNPs to investigate the possible relationship between innate immunity deregulation by disruption of TLR2 and potential BC development.

show abstract

“…Upon analysis of liver samples from patients at different stages of liver disease, Soares and colleagues found that Tlr2 and Tlr4 mRNA were decreased in patients with hepatocarcinoma (25). In addition, several studies have demonstrated that single-nucleotide polymorphisms (SNP) in Tlr2 are associated with HCC susceptibility (26,27). The frequency of the Tlr2-196-174 del allele was significantly higher in patients with HCV-associated HCC.…”

Section: Discussionmentioning

confidence: 99%

TLR2 Limits Development of Hepatocellular Carcinoma by Reducing IL18-Mediated Immunosuppression

Sun

Chen

et al. 2015

Cancer Research

View full text Add to dashboard Cite

show abstract

The association between Toll-like receptor 2 single-nucleotide polymorphisms and hepatocellular carcinoma susceptibility

Cited by 63 publications

References 32 publications

Association between <em>TLR-9</em> polymorphisms and colon cancer susceptibility in Saudi Arabian female patients

Association between <em>TLR-9</em> polymorphisms and colon cancer susceptibility in Saudi Arabian female patients

No genetic relationship between <em>TLR2</em> rs4696480, rs3804100, and rs3804099 gene polymorphisms and female breast cancer in Saudi populations

TLR2 Limits Development of Hepatocellular Carcinoma by Reducing IL18-Mediated Immunosuppression

Contact Info

Product

Resources

About