The association between total antioxidant capacity and resting metabolic rate (RMR) / respiratory quotient (RQ) in overweight and obese woman

Aghamohammadi, Vajiheh; Sajjadi, Seyedeh Forough; Jarrahi, Farshad; Abdollahi, Afsoun; Mirzaei, Khadijeh

doi:10.1016/j.dsx.2019.07.030

Cited by 8 publications

(7 citation statements)

References 20 publications

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“…Strengthening of the antioxidant barrier in obese patients results undoubtedly from the improvement of metabolic status after bariatric surgery (↓BMI, ↓WHR, ↓UA, ↓LDL, ↓TG, ↓glucose, ↓insulin, and ↓HOMA-IR). An increased supply of food rich in antioxidants can also lead to weight loss and improved redox homeostasis [46,47]. Therefore, it is not surprising that better effects of bariatric surgery were achieved in obese patients without metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

Impact of Weight Loss on the Total Antioxidant/Oxidant Potential in Patients with Morbid Obesity—A Longitudinal Study

et al. 2020

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The assessment of total antioxidant activity seems to have a higher diagnostic value than the evaluation of individual antioxidants separately. Therefore, this is the first study to assess the total antioxidant/oxidant status in morbidly obese patients undergoing bariatric surgery. The study involved 60 patients with Class 3 obesity (BMI > 40 kg/m2) divided into two equal subgroups: morbidly obese patients without and with metabolic syndrome. The analyses were performed in plasma samples collected before surgery as well as 1, 3, 6, and 12 months after a laparoscopic sleeve gastrectomy. Total antioxidant capacity (TAC), ferric-reducing antioxidant power (FRAP), DPPH (2,2′-diphenyl-1-picrylhydrazyl) radical assay, and total oxidant status (TOS) were significantly higher before surgery (as compared to the healthy controls, n = 60) and generally decreased after bariatric treatment. Interestingly, all assessed biomarkers correlated positively with uric acid content. However, the total antioxidant/oxidant potential did not differ between obese patients without metabolic syndrome and those with both obesity and metabolic syndrome. Only DPPH differentiated the two subgroups (p < 0.0001; AUC 0.8) with 73% sensitivity and 77% specificity. Plasma TAC correlated positively with body mass index, waist–hip ratio, serum insulin, and uric acid. Therefore, TAC seems to be the best biomarker to assess the antioxidant status of obese patients.

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Section: Discussionmentioning

confidence: 99%

Impact of Weight Loss on the Total Antioxidant/Oxidant Potential in Patients with Morbid Obesity—A Longitudinal Study

et al. 2020

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“…For FRAP, we used a database developed by Halvorsen et al Total antioxidant capacity values for each food item in the FFQ were matched to an equivalent food in each of the databases. If any food was not directly matched with a corresponding food in a database, a proxy estimation was used based on the mean value of a similar food or the value of a raw food as a substitute for the cooked food [19,21]. DTAC for every participant was obtained by multiplying the daily intake of each selected food item by its corresponding antioxidant value per food portion and summing the nal values.…”

Section: Dietary Assessment and Dtac Evaluationmentioning

confidence: 99%

“…According to estimates, polymorphisms in this gene are responsible for 2.4-9% of signi cant obesity and has a tight interaction with environmental factors [11][12][13] There are also some variants in the MC4R gene, which may have preventive effects on obesity [7,14]. Several variants in the MC4R gene have been identi ed which rs17782313 polymorphism (T/C) is one of those frequently described [15][16][17][18][19][20][21]. A higher BMI and energy intake in people with the common SNP rs17782313 near MC4R gene have also been observed [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Association of Dietary Total Antioxidant Capacity and MC4R Polymorphisms in Metabolically Healthy and Unhealthy Overweight/Obese Women

Elhamkia

Setayesh

Yarizadeh

et al. 2021

Preprint

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Background: 3-15% of people with obesity display a metabolically healthy phenotype. An inflammatory diet impairs metabolic signaling pathways and eliciting metabolic syndrome. The main purpose of this study was to investigate how the Dietary Total Antioxidant Capacity (DTAC) and the MC4R variants affect the metabolic health status in overweight and obese Iranian women.Methods and results: This cross-sectional study was conducted on 237 overweight-obese Tehrani women with mean age of 36 years.The DTAC was calculated using the following indices: total reactive antioxidant potential (TRAP), Trolox equivalent antioxidant capacity (TEAC), and the ferric-reducing ability of plasma (FRAP). The Metabolic health was evaluated using the Karelis criteria. The MC4R genotypes were determined by the restriction fragment length polymorphism (PCR-RFLP) method. Approximately 43% of participants were identified as Metabolically Unhealthy Obesity (MUO), 6% Metabolically Healthy Obesity (MHO) including 42.5% of the total had T/T genotype ,23.8% had the C/T genotype, and 33.5% had the C/C genotype (P=0.05). In the C/C genotype people 75% were unhealthy whereas it was lower in T/T and T/C genotype people. Further, The C/C genotype with higher DTAC quartile had higher Karlis score than other DTAC quartile. A liner model test supported that the probability of MHO was significantly higher in subjects with the T/C genotype (β=-0.001, 95% CI= -0.001-4.796; P ≤ 0.1). Conclusions: Our results indicated that the C/C genotype with higher DTAC had favorable lipid profile and were metabolically healthier. It is plausible that dietary modification targeting antioxidant intake may attenuate metabolic impairments associated with genetic predisposition.

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“… 18 , 19 Several variants in the MC4R gene have been identified, and rs 17782313 polymorphism (C) is one of those frequently described. 20 - 25 …”

Section: Introductionmentioning

confidence: 99%

“…18,19 Several variants in the MC4R gene have been identified, and rs17782313 polymorphism (C) is one of those frequently described. [20][21][22][23][24][25] Findings suggest that the difference between the metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO) phenotypes may be partly attributed to specific genetic traits modulating body fat distribution in different regional fat depots which distributed in different regional fat depots, held diverse biological properties and functions. 17 On the other hand, oxidative stress plays an important role in the prevalence of metabolic complications.…”

Section: Introductionmentioning

confidence: 99%

The Interaction Between Dietary Total Antioxidant Capacity and MC4R Gene and HOMA-IR in Metabolically Healthy and Unhealthy Overweight and Obese Women

Elhamkia

Setayesh

Yarizadeh

et al. 2022

Nutr Metab Insights

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Introduction: The current prevalence of the metabolically healthy obesity is about 3%. Genetic and nutrition are influencers of such phenotypes. The main goal of this study was to assess the interaction between Dietary Total Antioxidant Capacity (DTAC) and the genotypes of MC4R and Insulin resistance in metabolically healthy/unhealthy overweight and obese women in Iran. Material And Methods: This cross-sectional study was conducted on 237 overweight-obese women with a mean age of 36. The value of Dietary total antioxidant capacity (DTAC) was calculated using the following indices: Total reactive antioxidant potential (TRAP), Trolox equivalent antioxidant capacity (TEAC), and ferric reducing ability of plasma (FRAP). The Metabolic health status was evaluated using the Karelis criteria. Melanocortin 4 receptor single nucleotide polymorphisms were determined by the restriction fragment length polymorphism (PCR-RFLP) method. Also, insulin resistance was evaluated through homeostasis model assessment (HOMA). Result: Our data noted that 72.96% of participants presented Unhealthy Metabolically and 26.94% Healthy Metabolically including 33.5% of the total had T/T genotype, 23.8% had the C/T genotype, and 42.5% had the C/C genotype ( P = .05). A linear regression model test showed that the probability of metabolically healthy obesity was significantly higher in patients with the T/C genotype. The test value was statistically significant (95% CI: 0.000-0.001; P = .056, β = 0). No statistically significant relation was observed between study parameters and DTAC values. HOMA-Index was higher in all unhealthy subjects significantly. Conclusions: The findings indicated that there are significant associations between genotypes of rs1333048 SNP and DTAC. The C/C genotype subjects with higher DTAC had a better lipid profile and were metabolically healthier.

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The association between total antioxidant capacity and resting metabolic rate (RMR) / respiratory quotient (RQ) in overweight and obese woman

Cited by 8 publications

References 20 publications

Impact of Weight Loss on the Total Antioxidant/Oxidant Potential in Patients with Morbid Obesity—A Longitudinal Study

Impact of Weight Loss on the Total Antioxidant/Oxidant Potential in Patients with Morbid Obesity—A Longitudinal Study

Association of Dietary Total Antioxidant Capacity and MC4R Polymorphisms in Metabolically Healthy and Unhealthy Overweight/Obese Women

The Interaction Between Dietary Total Antioxidant Capacity and MC4R Gene and HOMA-IR in Metabolically Healthy and Unhealthy Overweight and Obese Women

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