The association between transforming growth factor beta1 polymorphism and susceptibility to pulmonary fibrosis

Abstract

Although many studies have investigated the association of single nucleotide polymorphisms (SNPs) in transforming growth factor beta1 (TGF-β1) gene with pulmonary fibrosis (PF), but their association is still controversial. To clarify this, we performed a meta-analysis.Studies related to TGF-β1 and PF were retrieved from PubMed, Medline, Embase, Scopus, and Wanfang (up to November 30, 2017). We targeted TGF-β1 SNPs that have been reported by ≥3 studies to be included in the current meta-analysis, resulting in only 1 final SNP (rs1800470). The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated in the models of allele comparison (T vs C), homozygote comparison (TT vs CC), dominant (TT vs TC + CC), recessive (TT + TC vs CC) to evaluate the strength of the associations.A total of 7 case-control studies were included in this meta-analysis. Overall, no significant association between TGF-β1 rs1800470 and PF was found (T vs C: OR [95% CI] = 0.96 [0.80, 1.15]; TT vs CC: 0.87 [0.61, 1.22]; TT vs TC + CC: 0.80 [0.62, 1.04]; TT + TC vs CC: 1.13 [0.83, 1.54]). In subgroup analyses by ethnicity or original disease, no statistically significant association between TGF-β1 rs1800470 polymorphisms and PF was demonstrated.This meta-analysis revealed that TGF-β1 rs1800470 polymorphism was not associated with susceptibility to PF development.

Association of Polymorphisms in IL-10, TGF-β1, IFN-γ, and TNF-α Genes with the Susceptibility to Chronic Obstructive Pulmonary Disease in Kerman, Iran

“…In the lungs, the secretion of TGF-β 1 by bronchial epithelial cells stimulates fibroblast propagation (17). Moreover, TGF-β 1 production is under genetic control, and several polymorphisms in the TGF-β 1 gene have been identified (18), of which two of the most important SNPs were examined in the present study: the + 869 T/C (Leu/ Pro) at codon 10 (rs1982073) and + 915 G/C (Arg/ Pro) at codon 25 (rs1800471). For TGF-β1 at codon 10 individuals homozygous for the C allele are considered low manufacturers and those with genotype T as high manufacturers of TGF-β1 at codon 10 and for TGF-β1 at codon 25 individuals homozygous for the C allele are considered low manufacturers and those with genotype G as high manufacturers of TGF-β1 at codon 25.…”