The association between two single nucleotide polymorphisms within the insulin-degrading enzyme gene and Alzheimer’s disease in a Chinese Han population

Cui, Pei‐Jing; Cao, Li; Wang, Ying; Deng, Yulei; Xu, Wei; Wang, Gang; Zhang, Yu; Zheng, Lan; Fei, Qing-Zhou; Zhang, Ting; Chen, Shengdi

doi:10.1016/j.jocn.2011.08.036

Cited by 9 publications

(3 citation statements)

References 31 publications

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“…Another study reported an increased risk of LOAD in APOE∊4 noncarriers and male patients due to variation in rs1887922, 23 and a significant association was found between AD and rs1887922 in a Northern Chinese Han population, 24 while our study also showed the variant to be more associated with LOAD in APOE∊4 noncarriers and male patients. Interestingly, rs1887922 was also shown to be associated with a higher risk of type 2 diabetes 25,26 ; this patient group is also at greater risk of developing AD than nondiabetic individuals.…”

Section: Discussionsupporting

confidence: 60%

Association Between Polymorphisms of the Insulin-Degrading Enzyme Gene and Late-Onset Alzheimer Disease

Wang

2014

J Geriatr Psychiatry Neurol

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The insulin-degrading enzyme (IDE) gene is a strong positional and biological candidate for late-onset Alzheimer disease (LOAD) susceptibility, with recent studies independently demonstrating an association between IDE gene variants and LOAD. However, previous data have been controversial. To investigate the relationship between IDE gene polymorphisms and LOAD risk, a case-control association study of 406 Han Chinese participants in Xinjiang, China, was undertaken. The LOAD and control groups consisted of 202 and 204 participants, respectively. The single-nucleotide polymorphisms rs1887922 and rs1999764 of the IDE gene were linked to LOAD incidence. The presence of the CT+CC genotype of rs1999764 had a protective effect compared to the TT genotype (adjusted P=.0001; odds ratio [OR]=0.226; 95% confidence interval [CI]=0.116-0.441), while the CT+CC genotype of rs1887922 was associated with increased LOAD risk (adjusted P=.0001; OR=3.640; 95% CI=1.889-7.016). Moreover, the effects of rs1887922 and rs1999764 were associated with LOAD risk independent of the apolipoprotein E ∊4 polymorphism and were more significant in men and women, respectively. These results demonstrate that the polymorphisms rs1887922 and rs1999764 of the IDE gene are associated with LOAD susceptibility in the Xinjiang Han population.

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Section: Discussionsupporting

confidence: 60%

Association Between Polymorphisms of the Insulin-Degrading Enzyme Gene and Late-Onset Alzheimer Disease

Wang

2014

J Geriatr Psychiatry Neurol

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“…IDE is also a metalloprotease enzyme responsible for insulin degradation [8]. Previous studies indicated that IDE is genetically associated with AD in the Finnish, Chinese, and Europen populations [9,10]. In addition, some linkage studies have identified chromosome 10q as a site of a number of markers for increased plasma levels of Aβ that are close to the IDE site [11–14].…”

Section: Introductionmentioning

confidence: 99%

Insulin degrading enzyme contributes to the pathology in a mixed model of Type 2 diabetes and Alzheimer’s disease: possible mechanisms of IDE in T2D and AD

Zhu

et al. 2018

Bioscience Reports

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Correspondence : Huajie Li (lihuajie0589@sohu.com) Insulin degrading enzyme (IDE) is believed to act as a junction point of Type 2 diabetes (T2D) and Alzheimer's disease (AD); however, the underlying mechanism was not completely clear yet. Transgenic APPSwe/PS1 mice were used as the AD model and were treated with streptozocin/streptozotocin (STZ) to develop a mixed mice model presenting both AD and T2D. Morris Water Maze (MWM) and recognition task were performed to trace the cognitive function. The detection of fasting plasma glucose (FPG) and plasma insulin concentration, and oral glucose tolerance test (OGTT) were used to trace the metabolism evolution. Aβ40 and Aβ42 were quantified by colorimetric ELISA kits. The mRNA or protein expression levels were determined by quantitative real-time RT-PCR and Western blotting analysis respectively. T2D contributes to the AD progress by accelerating and worsening spatial learning and recognition impairments. Metabolic parameters and glucose tolerance were significantly changed in the presence of the AD and T2D. The expression levels of IDE, PPARγ, and AMPK were down-regulated in mice with AD and T2D. PPARγ activator rosiglitazone (RSZ) or AMPK activator AICAR increased the expression level of IDE and decreased Aβ levels in mice with AD and T2D. RSZ or AICAR treatment also alleviated the spatial learning and recognition impairments in AD and T2D mice. Our results found that, in the mice with T2D and AD, the activators of PPARγ/AMPK signaling pathway significantly increased the expression level of IDE, and decreased the accumulation of Aβ40 and Aβ42, as well as alleviated the spatial learning and recognition impairments.

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“…Tato zinková meta-loproteináza štěpí několik peptidů, např. glukagon, inzulín, β-endorfín nebo intracelulární doménu APP (43). Bylo také zjištěno, že tento enzym může degradovat Aβ in vitro, což by mohlo ovlivnit průběh ACH (42).…”

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Genetic predisposition to Alzheimer's disease

Hálová¹,

Ambrozová²,

Ambrož³

et al. 2020

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Alzheimerova choroba je nejčastější neurodegenerativní onemocnění, na jehož vzniku se podílí řada faktorů -jedním z nich je genetická predispozice. Celogenomové asociační studie umožňují nalézt kandidátní geny, jejichž změny by mohly přispět ke vzniku tohoto onemocnění. Cíl: Tato literární rešerše shrnuje dosavadní poznatky celogenomových asociačních studií zaměřených na stanovení genetické predispozice Alzheimerovy choroby s pozdním nástupem. Jejím cílem je sestavit přehled kandidátních genů asociovaných s touto nemocí pro účely budoucího výzkumu. Metody: Práce je zpracována formou literární rešerše. Popisuje významné geny, které jsou asociovány s Alzheimerovou chorobou s pozdním nástupem. Výsledky: Na základě dosavadních zkušeností byly vybrány geny APOE, TOMM40, CD36, CLU, CHAT, IDE a TNK1, které jsou nejvhodnějšími kandidáty pro budoucí cílené genetické vyšetřování u české populace. Závěry: Tato práce předložila seznam genů asociovaných s Alzheimerovou chorobou s pozdním nástupem. Budoucí výzkum v této oblasti může významně přispět k predikci a následné prevenci tohoto závažného onemocnění.

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The association between two single nucleotide polymorphisms within the insulin-degrading enzyme gene and Alzheimer’s disease in a Chinese Han population

Cited by 9 publications

References 31 publications

Association Between Polymorphisms of the Insulin-Degrading Enzyme Gene and Late-Onset Alzheimer Disease

Association Between Polymorphisms of the Insulin-Degrading Enzyme Gene and Late-Onset Alzheimer Disease

Insulin degrading enzyme contributes to the pathology in a mixed model of Type 2 diabetes and Alzheimer’s disease: possible mechanisms of IDE in T2D and AD

Genetic predisposition to Alzheimer's disease

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