The association between urinary phytoestrogen excretion and components of the metabolic syndrome in NHANES

Struja, Tristan; Richard, Aline; Linseisen, Jakob; Eichholzer, Monika; Rohrmann, Sabine

doi:10.1007/s00394-013-0639-y

Cited by 24 publications

(23 citation statements)

References 55 publications

(86 reference statements)

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“…Dietary phytoestrogens have also been suggested to play a beneficial role in obesity, metabolic syndrome and type 2 diabetes (Bhathena and Velasquez, ; Cederroth and Nef, ; Crespillo et al , ; Jungbauer and Medjakovic, ; Struja et al , ). The meta‐analysis by Fang et al () reported an improvement in glucose metabolism and a significant reduction in insulin levels and insulin resistance in menopausal women, by especially genistein.…”

Section: Introductionmentioning

confidence: 99%

The potential health effects of dietary phytoestrogens

Rietjens

Louisse

Beekmann

2016

British J Pharmacology

418

246

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Phytoestrogens are plant‐derived dietary compounds with structural similarity to 17‐β‐oestradiol (E2), the primary female sex hormone. This structural similarity to E2 enables phytoestrogens to cause (anti)oestrogenic effects by binding to the oestrogen receptors. The aim of the present review is to present a state‐of‐the‐art overview of the potential health effects of dietary phytoestrogens. Various beneficial health effects have been ascribed to phytoestrogens, such as a lowered risk of menopausal symptoms like hot flushes and osteoporosis, lowered risks of cardiovascular disease, obesity, metabolic syndrome and type 2 diabetes, brain function disorders, breast cancer, prostate cancer, bowel cancer and other cancers. In contrast to these beneficial health claims, the (anti)oestrogenic properties of phytoestrogens have also raised concerns since they might act as endocrine disruptors, indicating a potential to cause adverse health effects. The literature overview presented in this paper illustrates that several potential health benefits of phytoestrogens have been reported but that, given the data on potential adverse health effects, the current evidence on these beneficial health effects is not so obvious that they clearly outweigh the possible health risks. Furthermore, the data currently available are not sufficient to support a more refined (semi) quantitative risk–benefit analysis. This implies that a definite conclusion on possible beneficial health effects of phytoestrogens cannot be made.Linked ArticlesThis article is part of a themed section on Principles of Pharmacological Research of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.11/issuetoc

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Section: Introductionmentioning

confidence: 99%

The potential health effects of dietary phytoestrogens

Rietjens

Louisse

Beekmann

2016

British J Pharmacology

418

246

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“…In the last 5 years, additional observational studies looking at urinary enterolactone or enterodiol have been published using NHANES data, which is a nationally representative sample of the U.S. population. Studies evaluated different classifications of urinary enterolignans and populations . The results from NHANES studies support that urinary enterolactone and enterodiol are associated with more favorable cardiometabolic risk factors, including BMI, abdominal obesity, triglycerides, HDL cholesterol, blood pressure, and inflammation, and that associations appear stronger for enterolactone.…”

Section: Other Phytoestrogensmentioning

confidence: 86%

Section: Other Phytoestrogensmentioning

confidence: 99%

Cardiometabolic risk and gut microbial phytoestrogen metabolite phenotypes

Frankenfeld

2016

Molecular Nutrition Food Res

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Recent evidence supports that the gut microbial community, independently and/or interactively with dietary intake, is a target for reducing cardiovascular disease risk through its effects on cardiometabolic risk factors. Dietary phytoestrogens may be a source for interactive effects. Phytoestrogens, such as isoflavones, lignans, and flavonoids, are compounds found in plants that have estrogenic or antiestrogenic activities, as well as antioxidant, antiproliferative, or apoptotic actions. Given these physiological activities, phytoestrogens may have a role in cardiometabolic health. Some phytoestrogens consumed in the diet undergo biotransformation through gut bacterial metabolism to other compounds that may exhibit similar or different physiological activity than the parent compound. There is interindividual variability in the capability to metabolize phytoestrogens to their metabolites, and there is a resulting phenotype that can be evaluated based on urinary metabolite excretion. Evidence suggests that phytoestrogen metabolites and/or phenotypes are associated with cardiometabolic risk factors, such as blood pressure, abdominal obesity, and serum lipids, triglycerides, glucose, and inflammatory markers. The objective of this review was to provide an overview of the observed associations between gut microbial phytoestrogen metabolites and metabolite phenotypes with cardiometabolic risk factors, with focus on the more extensively studied isoflavone metabolites.

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“…The results from these previous studies are consistent with those of the present study. This protective effect of enterolactone on cardiovascular disease may be partially attributable to the inverse associations of its high urinary concentrations with inflammation biomarkers (C-reactive protein and white blood cell counts), obesity, and metabolic syndrome in human studies [56][57][58]. Animal and in vitro studies have offered additional mechanistic basis for the reduced cardiovascular mortality associated with elevated levels of urinary enterolactone [59][60][61].…”

Section: Discussionmentioning

confidence: 99%

Urinary phytoestrogens and cancer, cardiovascular, and all-cause mortality in the continuous National Health and Nutrition Examination Survey

et al. 2015

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2 AbstractPurpose: Experimental studies suggest that phytoestrogen intake alters cancer and cardiovascular risk. This study investigated the associations of urinary phytoestrogens with total cancer (n=79), cardiovascular (n=108), and allcause (n=290) mortality among 5,179 participants in the continuous National Health and Nutrition Examination Survey (1999Survey ( -2004.Methods: Urinary phytoestrogens were measured using high performance liquid chromatography with tandem mass spectrometric detection. Survival analysis was performed to evaluate hazard ratios (HRs) and 95% confidence intervals (CIs) for each of the three outcomes in relation to urinary phytoestrogens.Results: After adjustment for confounders, higher urinary concentrations of total enterolignans were associated with a reduced risk of death from cardiovascular disease (HR for tertile 3 vs. tertile 1: 0.48; 95% CI: 0.24, 0.97), whereas higher urinary concentrations of total isoflavones (HR for tertile 3 vs. tertile 1: 2.14; 95% CI: 1.03, 4.47) and daidzein (HR for tertile 3 vs. tertile 1: 2.05; 95% CI: 1.02, 4.11) were associated with an increased risk. A reduction in all-cause mortality was observed for elevated urinary concentrations of total enterolignans (HR for tertile 3 vs. Conclusions: Some urinary phytoestrogens were associated with cardiovascular and all-cause mortality in a representative sample of the U.S. population. This is one of the first studies that used urinary phytoestrogens as biomarkers of their dietary intake to evaluate the effect of these bioactive compounds on the risk of death from cancer and cardiovascular disease.

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The association between urinary phytoestrogen excretion and components of the metabolic syndrome in NHANES

Abstract: Our study shows that an increasing excretion of lignans, especially enterolactone, might be associated with a decreased presence of the metabolic syndrome.

Cited by 24 publications

References 55 publications

The potential health effects of dietary phytoestrogens

The potential health effects of dietary phytoestrogens

Cardiometabolic risk and gut microbial phytoestrogen metabolite phenotypes

Urinary phytoestrogens and cancer, cardiovascular, and all-cause mortality in the continuous National Health and Nutrition Examination Survey

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