The Association Between Vitamin D and Inflammation with the 6‐Minute Walk and Frailty in Patients with Heart Failure

Abstract

Twenty-five-hydroxyvitamin D and hsCRP levels may contribute to lower aerobic capacity and frailty in patients with heart failure. A longitudinal study will further define the role of 25OHD and hsCRP on muscle strength and functional decline.

Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: The EPIDOS study

“…(10,(16)(17)(18)(19)(20)(21)(22) It has been shown that ambulation time over an 8-ft walkway correlated with higher serum 25(OH)D concentrations. (10,18) Gerdhem and colleagues (19) also have reported a positive significant linear correlation with usual walking speed in a cohort of 986 elderly women.…”

“…Second, previous studies used different cutoff values for abnormal serum 25(OH)D concentrations ranging from 10 to 30 ng/mL, (10,(16)(17)(18)(19)(20)(21)(22) which also may explain the divergences. From a historical point of view, normal vitamin D concentrations have been defined by the avoidance of adverse health consequences.…”

“…(41) In addition, iPTH already has been associated with usual walking speed in unadjusted models. (17,19) However, the specific roles of vitamin D and iPTH on muscle and locomotion have not yet been fully elucidated. In our study, the existence of an association between 25(OH)D and walking speed, even after adjustment for iPTH effect, sustains the notion of a direct neuromuscular action of vitamin D, especially because iPTH was not associated with walking speed even in the unadjusted linear regression model.…”

“…(16) Compared with muscle strength or balance performance, (5)(6)(7) fewer attempts have been made to explore the association between low chronic serum 25(OH)D concentrations and walking speed. (10,(16)(17)(18)(19)(20)(21)(22) A better understanding of this association is important to further develop interventional clinical studies to assess the effect of vitamin D supplementation on mobility and gait performance and related adverse health consequences. Previous studies showed conflicting results because some of them found a significant positive association, (10,(16)(17)(18)(19)(20) whereas others did not.…”

“…(10,(16)(17)(18)(19)(20)(21)(22) A better understanding of this association is important to further develop interventional clinical studies to assess the effect of vitamin D supplementation on mobility and gait performance and related adverse health consequences. Previous studies showed conflicting results because some of them found a significant positive association, (10,(16)(17)(18)(19)(20) whereas others did not. (21,22) These differences may be related, in part, to the type of walking speed measured.…”