The Association of a Novel Identified <i>VDR</i> SNP With Prostate Cancer in African American Men

Daremipouran, Mohammad; Beyene, Desta; Apprey, Victor; Naab, Tammey; Kassim, Olakunle O.; Copeland, Robert L.; Kanaan, Yasmine

doi:10.21873/cgp.20129

Cited by 11 publications

(11 citation statements)

References 47 publications

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“…Moreover, a case-control study from England revealed a 3-fold increased risk to be associated with a low lifetime UV sunlight exposure (12). Results from our previous studies (23,24) have shown that outdoor UV sunlight exposure was associated with reduced PCa risk.…”

Section: Discussionmentioning

confidence: 92%

“…However, Berndt et al did not find evidence to support an association between any of the VDR polymorphisms and the risk of PCa (33). We recently reported that VDR SNPs 4 (c907+75C>T) and 7 (rs7975232) play a significant role in the development of PCa in African Americans (7,23). The cumulative effects of VDR polymorphism, UV sunlight exposure, and vitamin D level on PCa risk has also been investigated by other researchers (34,35).…”

Section: Discussionmentioning

confidence: 96%

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The Association Between the Genetic VDR SNP c.907+75C>T and Prostate Cancer Risk Is Modified by Tanning Potential

Beyene

Daremipouran

Apprey

et al. 2020

Cancer Genomics Proteomics

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Background: Prostate cancer (PCa) is a multifactorial disease involving complex interactions between genetic and physiological/environmental factors. Vitamin D receptor (VDR) plays a role in numerous cellular pathways and it has been suggested that VDR genetic variants influence individual susceptibility to PCa. Materials and Methods: Logistic regression analysis was used to assess the association of six VDR single nucleotide polymorphisms (SNPs) and factors such as tanning potential and UV sunlight exposure with PCa risk. Results: Marginal significant interactions were found, with a 2-fold increase risk of PCa between SNP 1 (c.278-69G>A) and sunlight UV exposure [odds ratio (OR)=2.02, 95% confidence intervaI (CI)=1.036-4.36; p=0.05]; and a 4-fold increase risk of PCa between SNP 4 (c.907+75C>T) and tanning potential (OR=4.40, 95% CI=0.89-29.12; p=0.0591). In contrast, SNP 5 (rs731236, TaqI) and tanning potential interaction had a protective effect by reducing the risk of PCa by 55% (β=−0.804; OR=0.448, 95% CI=0.197-9.42; p=0.0427). SNPs 2 (rs61614328) and 6 (rs533037428) did not show any association with PCa even in the presence of UV sunlight exposure. Conclusion: The protective effect of SNP 4 from PCa is lost and modified by tanning potential in African Americans. This finding needs to be verified by larger studies in different ethnic populations. Prostate cancer (PCa) has high incidence as well as high mortality, which makes it an important worldwide health issue (1, 2). Furthermore, PCa etiology is complex, involving many risk factors such as age, vitamin D status, ethnic origin, and family history of PCa (3, 4). Epidemiological studies suggest that PCa risk may at least partly be determined by interactions between the environment and genetic predisposition (5-7). PCa rates are higher in African American men compared to other ethnic groups in the United States (4, 5, 8). Additionally, this group of men are more likely to be diagnosed at a later stage of disease development. PCa risk has been inversely associated with sun exposure. In most individuals, about 90% of circulating levels of 25hydroxyvitamin D are derived from casual sun exposure (9). In the United States, high residential sun exposure has been associated with lower mortality rates and reduced risk for PCa (10, 11). A case-control study by Luscombe et al. found a 3fold increased risk with low lifetime sun exposure (12). Vitamin D is an important candidate implicated in PCa risk and its deficiency has been hypothesized to be a risk factor for PCa (13, 14). Reduced vitamin D levels correlate with established risk factors such as increasing age, African American ethnicity, and residence in northern latitudes (15). Cordera et al. also used diagnostic serum samples from blood to show that the risk of PCa decreased with higher levels of 1,25-dihydroxyvitamin D (6). The physiological and environmental factors that modify the supply of cutaneous vitamin D are levels of UV exposure, skin pigmentation, and polymorphism in the vitamin D receptor (VDR) gene ...

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 96%

The Association Between the Genetic VDR SNP c.907+75C>T and Prostate Cancer Risk Is Modified by Tanning Potential

Beyene

Daremipouran

Apprey

et al. 2020

Cancer Genomics Proteomics

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“…Different studies have examined the effect of IL-6 SNP and/or IL-8 SNP on diseases' risk, activity, and progression. Results showed marked ethnicity-associated disparities and diverse findings [12,[16][17][18][19][20][21][22][23]. For instance, a meta-analysis of European and Asian studies on IL-6 SNP and rheumatoid arthritis (RA) risk showed that IL-6 SNP was significantly associated with RA in Asian patients but not in the Caucasian population [20].…”

Section: Discussionmentioning

confidence: 99%

Relevance of Interleukins 6 and 8 Single Nucleotide Polymorphisms in Prostate Cancer: A Multicenter Study

Ghazy

Alenzi

2021

Prostate Cancer

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The diverse roles of cytokines as IL-6 and IL-8 have been studied in terms of their SNPs in many diseases but their role in prostate cancer (PCa) is still uncertain. Aim. To determine the relevance of IL-6 rs1800795 SNP and/or IL-8 rs2227306 SNP with prostate cancer’s risk. Subjects and Methods. 40 PCa patients, 40 benign prostate hyperplasia (BPH) patients, and 40-age-matched-control group were enrolled in the study. Genotyping of IL-6 rs1800795 (G/C) SNP and IL-8 rs2227306 (C/T) SNP was determined using real-time PCR. Results. High frequency of IL-6 rs1800795GG and IL-8 rs2227306CC genotypes was noticed among PCa patients with associated OR 10.091 and 8.143, respectively. Comparisons based on allele frequencies revealed that IL-6G and IL-8C alleles are more frequent among PCa patients than other groups. Presence of IL-6 rs1800795G and IL-8 rs2227306C alleles in the same patient increase PCa risk by 16.7 times. Statistical correlations between PSA ratio and both of IL-6 and IL-8 SNP did not show any significant relation among PCa patients. Conclusion. IL-6 rs1800795G and IL-8 rs2227306C alleles could be considered risk factors for PCa development, particularly if presented together. However, no relation was found between both cytokines SNP and severity of prostate cancer.

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“…Previously, three SNPs located near base excision repair genes were found to be negatively associated with Wilms tumor risk [32]. SNPs in the vitamin D receptor gene have also been linked to decreased risk in prostate cancer in African American men [33] and rs1866074 near the thymine DNA glycosylase gene were reported to be correlated with lower colorectal cancer risk [34]. The minor allele of rs112837127 is most prevalent in British and Finnish populations where the allele frequency could be > 5% while no African or east Asian population carries this allele [35].…”

Section: Discussionmentioning

confidence: 99%

Low-frequency variation near common germline susceptibility loci are associated with risk of Ewing sarcoma

et al. 2020

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The Association of a Novel Identified VDR SNP With Prostate Cancer in African American Men

Cited by 11 publications

References 47 publications

The Association Between the Genetic VDR SNP c.907+75C>T and Prostate Cancer Risk Is Modified by Tanning Potential

The Association Between the Genetic VDR SNP c.907+75C>T and Prostate Cancer Risk Is Modified by Tanning Potential

Relevance of Interleukins 6 and 8 Single Nucleotide Polymorphisms in Prostate Cancer: A Multicenter Study

Low-frequency variation near common germline susceptibility loci are associated with risk of Ewing sarcoma

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