The association of affective disorders and facial scarring: Systematic review and meta-analysis

Gibson, John; Ackling, Edward; Bisson, Jonathan I.; Dobbs, Thomas D.; Whitaker, Iain S.

doi:10.1016/j.jad.2018.06.013

Cited by 19 publications

(21 citation statements)

References 48 publications

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“…Unfortunately, these surgeries represent a second injury that may heal with repeated pathological scar in certain individuals. The burden of dysfunction and disfigurement associated with scars can also negatively impact psychological health, particularly of children (Gibson et al, 2018). This is particularly true of craniofacial scars, which have been linked by several studies to an especially high risk of depression and lower quality of life (Rumsey and Harcourt, 2004; Roberts and Gierasch, 2013).…”

Section: Craniofacial Skin Healingmentioning

confidence: 99%

The Spectrum of Scarring in Craniofacial Wound Repair

et al. 2019

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Fibrosis is intimately linked to wound healing and is one of the largest causes of wound-related morbidity. While scar formation is the normal and inevitable outcome of adult mammalian cutaneous wound healing, scarring varies widely between different anatomical sites. The spectrum of craniofacial wound healing spans a particularly diverse range of outcomes. While most craniofacial wounds heal by scarring, which can be functionally and aesthetically devastating, healing of the oral mucosa represents a rare example of nearly scarless postnatal healing in humans. In this review, we describe the typical wound healing process in both skin and the oral cavity. We present clinical correlates and current therapies and discuss the current state of research into mechanisms of scarless healing, toward the ultimate goal of achieving scarless adult skin healing.

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Section: Craniofacial Skin Healingmentioning

confidence: 99%

The Spectrum of Scarring in Craniofacial Wound Repair

et al. 2019

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“…This behaviour will interfere with future work life and relationships. In some contexts, scars result from traumatising events and bury a psychological meaning ( Brown et al, 2008 ; Gibson et al, 2018 ; Mitchell et al, 2019 ). On the other hand, while visible skin scarring implies a social burden, oral and oesophagus scarring result in difficulties swallowing food and weight loss ( Campos et al, 2020 ).…”

Section: Wound Repair Mechanisms In Skin Oesophagus and Oral Epitheliamentioning

confidence: 99%

A Scarless Healing Tale: Comparing Homeostasis and Wound Healing of Oral Mucosa With Skin and Oesophagus

Pereira

Sequeira

2021

Front. Cell Dev. Biol.

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Epithelial tissues are the most rapidly dividing tissues in the body, holding a natural ability for renewal and regeneration. This ability is crucial for survival as epithelia are essential to provide the ultimate barrier against the external environment, protecting the underlying tissues. Tissue stem and progenitor cells are responsible for self-renewal and repair during homeostasis and following injury. Upon wounding, epithelial tissues undergo different phases of haemostasis, inflammation, proliferation and remodelling, often resulting in fibrosis and scarring. In this review, we explore the phenotypic differences between the skin, the oesophagus and the oral mucosa. We discuss the plasticity of these epithelial stem cells and contribution of different fibroblast subpopulations for tissue regeneration and wound healing. While these epithelial tissues share global mechanisms of stem cell behaviour for tissue renewal and regeneration, the oral mucosa is known for its outstanding healing potential with minimal scarring. We aim to provide an updated review of recent studies that combined cell therapy with bioengineering exporting the unique scarless properties of the oral mucosa to improve skin and oesophageal wound healing and to reduce fibrotic tissue formation. These advances open new avenues toward the ultimate goal of achieving scarless wound healing.

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“…Facial disfigurements, including nasal and auricular defects following trauma, burns, skin cancer resection, and congenital conditions requiring reconstruction affect 569,000 (or 1 in 111) people in the United Kingdom (1). Facial deformity and scarring can have a devastating effect on an individual's appearance, psychological health and subsequently on their quality of life (2)(3)(4). When reconstructing facial defects all rungs of the reconstructive ladder must therefore be utilised to replace tissue like-for-like and ultimately optimise both the functional and cosmetic outcomes.…”

Section: Introductionmentioning

confidence: 99%

Facial Cartilaginous Reconstruction—A Historical Perspective, State-of-the-Art, and Future Directions

et al. 2021

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Importance: Reconstruction of facial deformity poses a significant surgical challenge due to the psychological, functional, and aesthetic importance of this anatomical area. There is a need to provide not only an excellent colour and contour match for skin defects, but also a durable cartilaginous structural replacement for nasal or auricular defects. The purpose of this review is to describe the history of, and state-of-the-art techniques within, facial cartilaginous surgery, whilst highlighting recent advances and future directions for this continually advancing specialty.Observations: Limitations of synthetic implants for nasal and auricular reconstruction, such as silicone and porous polyethylene, have meant that autologous cartilage tissue for such cases remains the current gold standard. Similarly, tissue engineering approaches using unrelated cells and synthetic scaffolds have shown limited in vivo success. There is increasing recognition that both the intrinsic and extrinsic microenvironment are important for tissue engineering and synthetic scaffolds fail to provide the necessary cues for cartilage matrix secretion.Conclusions and Relevance: We discuss the first-in-man studies in the context of biomimetic and developmental approaches to engineering durable cartilage for clinical translation. Implementation of engineered autologous tissue into clinical practise could eliminate donor site morbidity and represent the next phase of the facial reconstruction evolution.

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The association of affective disorders and facial scarring: Systematic review and meta-analysis

Abstract: There is a high and persistent burden of affective disorders in patients with facial scars. Additional research is required to further characterise this population and develop effective management strategies.

Cited by 19 publications

References 48 publications

The Spectrum of Scarring in Craniofacial Wound Repair

The Spectrum of Scarring in Craniofacial Wound Repair

A Scarless Healing Tale: Comparing Homeostasis and Wound Healing of Oral Mucosa With Skin and Oesophagus

Facial Cartilaginous Reconstruction—A Historical Perspective, State-of-the-Art, and Future Directions

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