The association of air pollutants exposure with subclinical inflammation and carotid atherosclerosis

Oikonomou, Evangelos; Lazaros, George; Mystakidi, Vasiliki Chara; Παπαϊωάννου, Νικόλαος; Theofilis, Panagiotis; Vogiatzi, Georgia; Chasikidis, Christos; Fountoulakis, Petros; Papakostantinou, Maria-Argentina; Assimakopoulos, Margarita Niki; Barmparesos, Nikolaos; Tasios, Panagiotis; Kaski, Juan Carlos; Tousoulis, Dimitris

doi:10.1016/j.ijcard.2021.07.056

Cited by 9 publications

(8 citation statements)

References 49 publications

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“…It was evidenced that increased atherosclerotic burden was observed in areas with higher levels of air pollutants [50]. PM 2.5 estimated by AOD adjusting for visibility and relative humidity was proved to be associated with atherosclerosis among healthy Chinese Han population [51].…”

Section: Discussionmentioning

confidence: 97%

Associations of Time-Weighted Individual Exposure to Ambient Particulate Matter with Carotid Atherosclerosis in Beijing, China

Han

Zhao

et al. 2022

Preprint

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Background Time-location information, including time spent indoors and outdoors around residential and work places and on commuting, physical activity, infiltrated ambient pollution and traffic transportations, was less considered estimating individual exposure to ambient pollution. Studies investigating the association between individual exposure to particulate matter (PM) with aerodynamic diameter <10 μm (PM10) and <2.5 μm (PM2.5) and carotid atherosclerosis obtained inconsistent results. Moreover, combined effect of mixed pollutants on carotid atherosclerosis was not fully explored because of high collinearity. We aimed to investigate the association between long-term individual time-weighted exposure to PM2.5 and PM10 and the risk of carotid atherosclerosis, and further explore the overall effects of multiple pollutants on carotid atherosclerosis. Methods Daily concentration of ambient pollutants was estimated by land-use regression model at both residential and work addresses, and 1-5 years’ time-weighted individual exposure was calculated by further considering personal activity pattern and infiltrated ambient pollution. We explored the association of PM2.5and PM10 with carotid atherosclerosis and pooled the overall effect of multiple pollutants by quantile g-computation. Results The significant association between time-weighted exposure to PM2.5 and PM10and carotid atherosclerosis was observed. Per interquartile range increase in 2-year exposure to PM2.5 (Hazard ratio (HR): 1.322, 95% confidence interval (CI): 1.219-1.434) and PM10 (HR:1.213, 95% CI: 1.116-1.319) showed the strongest association with carotid atherosclerosis, respectively. Individuals in higher quartiles of pollutants were at higher risk for carotid atherosclerosis. The linear and nonlinear relationships interpreted the upward trend of the risk for carotid atherosclerosis with increasing level of pollutant concentrations. Moreover, the overall adverse effects of multiple pollutants were further demonstrated. Conclusions Individual time-weighted exposure to PM2.5, PM10 and mixed pollutants was associated with carotid atherosclerosis. It is necessary to reduce individual pollutant exposure to inhibit the risk of carotid atherosclerosis and subsequently alleviate disease burdens of atherosclerotic diseases.

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Section: Discussionmentioning

confidence: 97%

Associations of Time-Weighted Individual Exposure to Ambient Particulate Matter with Carotid Atherosclerosis in Beijing, China

Han

Zhao

et al. 2022

Preprint

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show abstract

“…It was evidenced that increased atherosclerotic burden was observed in areas with higher levels of air pollutants [ 51 ]. PM 2.5 estimated by AOD adjusting for visibility and relative humidity was proved to be associated with atherosclerosis [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Associations of time-weighted individual exposure to ambient particulate matter with carotid atherosclerosis in Beijing, China

Han

Zhao

et al. 2023

Environ Health

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Background Time-location information (time spent on commuting, indoors and outdoors around residential and work places and physical activity) and infiltrated outdoor pollution was less considered estimating individual exposure to ambient air pollution. Studies investigating the association between individual exposure to particulate matter (PM) with aerodynamic diameter < 10 μm (PM10) and < 2.5 μm (PM2.5) and carotid atherosclerosis presented inconsistent results. Moreover, combined effect of pollutants on carotid atherosclerosis was not fully explored. We aimed to investigate the association between long-term individual time-weighted average exposure to PM2.5 and PM10 and the risk of carotid atherosclerosis, and further explore the overall effect of co-exposure to pollutants on carotid atherosclerosis. Methods The study population included 3069 participants derived from the Beijing Health Management Cohort (BHMC) study. Daily concentration of ambient air pollutants was estimated by land-use regression model at both residential and work addresses, and one- and two-year time-weighted average individual exposure was calculated by further considering personal activity pattern and infiltration of ambient air pollution indoors. We explored the association of PM2.5 and PM10 with carotid atherosclerosis and pooled the overall effect of co-exposure to ambient air pollutants by quantile g-computation. Results A significant association between time-weighted average exposure to PM2.5 and PM10 and carotid atherosclerosis was observed. Per interquartile range increase in two-year exposure to PM2.5 (Hazard ratio (HR): 1.322, 95% confidence interval (CI): 1.219–1.434) and PM10 (HR:1.213, 95% CI: 1.116–1.319) showed the strongest association with carotid atherosclerosis, respectively. Individuals in higher quartiles of pollutants were at higher risk for carotid atherosclerosis compared with those in the lowest quartile group. Concentration response functions documented the nearly linear and nonlinear relationship and interpreted the upward trends of the risk for carotid atherosclerosis with increasing level of pollutant concentrations. Moreover, effect estimates for the mixture of pollutants and carotid atherosclerosis were larger than any of the individual pollutants (HR (95% CI) was 1.510 (1.338–1.704) and 1.613 (1.428–1.822) per quartile increase for one-year and two-year time-weighted average exposure, respectively). Conclusions Individual time-weighted average exposure to PM2.5 and PM10 was associated with carotid atherosclerosis. Co-exposure to ambient air pollution was also positively associated with carotid atherosclerosis.

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“…Common carotid artery 45 [21,13,14,140,146,112,142,147,148,17,113,149,139,114,115,133,124,145,119,128,125,141,129,116,132,144,126,150,120,151,121,130,143,22,117,134,152,127,153,122,154,123,138,118] Internal carotid artery 1 [137] Brachial carotid artery 2 [155,156] Femoral artery 1 [135] Not reported 1 [131] Aspect of vasculature assessed…”

Section: Vascular Bed Assessedmentioning

confidence: 99%

“…Atherosclerosis and carotid plaques 19 [21,13,14,140,142,147,17,149,139,136,125,141,151,155,22,123,118] Arterial stiffness 3 [113,129,138] Arterial thickness 14 [135,148,137,114,115,133,124,119,144,126,121,130,156,153,122] Nonspecific cardiovascular risk factors 12 [146,112,114,115,145,131,116,150,120,143,134,127] Organ damage 1 [128] Not reported 1 [154] Technique Ultrasound 49…”

Section: Vascular Bed Assessedmentioning

confidence: 99%

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

et al. 2023

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Research involving human subjects in ambulatory settings is a critical link in the chain comprising translational research, spanning preclinical research to human subject and patient cohort studies. There are presently a wide array of techniques and approaches available to investigators wishing to study blood flow, perfusion, and vascular structure and function in human subjects. In this multi-sectioned review, we discuss capillaroscopy, carotid intima-media thickness, flow-mediated dilation, laser Doppler flowmetry, near-infrared spectroscopy, peripheral arterial tonometry, pulse wave velocity, retinal fundus imaging, and vascular plethysmography. Each section contains a general overview and the physical basis of the technique followed by a discussion of the procedures involved and the necessary equipment, with attention paid to specific requirements or limitations. Subsequently, we detail which aspects of vascular function can be studied with a given technique, the analytical approach to the collected data, and the appropriate application and limitation(s) to the interpretation of the data collected. Finally, a modified scoping review provides a summary of how each assessment technique has been applied in previous studies. It is anticipated that this review will provide an efficient source of information and insight for preclinical investigators seeking to add translational aspects to their research programs.

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The association of air pollutants exposure with subclinical inflammation and carotid atherosclerosis

Cited by 9 publications

References 49 publications

Associations of Time-Weighted Individual Exposure to Ambient Particulate Matter with Carotid Atherosclerosis in Beijing, China

Associations of Time-Weighted Individual Exposure to Ambient Particulate Matter with Carotid Atherosclerosis in Beijing, China

Associations of time-weighted individual exposure to ambient particulate matter with carotid atherosclerosis in Beijing, China

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

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