The association of albuminuria, arterial stiffness, and blood pressure status in nondiabetic, nonhypertensive individuals

Abstract

These findings demonstrate epidemiologic evidence for an independent association between arterial stiffness and microalbuminuria, indices of subclinical target organ damage in nonhypertensive, nondiabetic individuals, which suggests the possibility of a similar pathophysiologic mechanism involved in these two indices of subclinical target organ damage.

Determining the Optimal Cut-Off Value of the Urinary Albumin-To-Creatinine Ratio to Detect Atherosclerotic Vascular Diseases

“…Previous studies have examined the significant association between microalbuminuria and arterial stiffness measured by BaPWV in patients with hypertension or diabetes [11,12]. Recent findings in the general population are in agreement with those of previous studies [13,14]. The results of the present study are in close agreement with those of many other studies.…”

“…Moreover, lower UACRs compared with the conventional cut-off value are significantly associated with carotid atherosclerosis [9,10]. Microalbuminuria is significantly associated with arterial stiffness, not only in high-risk individuals with hypertension or diabetes [11,12], but also in the general population [13,14]. Most previous studies have examined the association between albuminuria and subclinical atherosclerosis in high-risk individuals, whereas only a few studies have investigated such an association in the general population.…”

The Association between Nonalcoholic Fatty Liver Disease, Metabolic Syndrome and Arterial Stiffness in Nondiabetic, Nonhypertensive Individuals

“…Although measurement of carotid-femoral pulse wave velocity (cfPWV) has been considered the noninvasive gold-standard measure of arterial stiffness, brachial-ankle pulse wave velocity (baPWV) has been widely used to screen for atherosclerotic vascular damage and to assess cardiovascular risk in the general population, especially in East Asian countries [9,10,11]. …”

Albuminuria as a marker of arterial stiffness in chronic kidney disease patients

“…In the study by Munakata et al [32] each 400 cm/s increase in brachialankle PWV, increased the incidence of new-onset moderately increased albuminuria about 2.4 times at 2-year follow-up, suggesting that higher brachialankle PWV could be an independent risk factor for the future development of moderately increased albuminuria in patients with hypertension [32] . A study by Kim et al [15] showed that AS is independently associated with moderately increased albuminuria, irrespectively of various covariates, in non-hypertensive, non-diabetic individuals. In our study we showed that these results are expanded to the patients with severely increased albuminuria.…”

“…High normal albuminuria in the range (0-30 mg/g) is also associated with aortic stiffness [12] even in younger type 2 diabetic patients with shorter durations of disease [13] , while in newly diagnosed patients with type 2 diabetes mellitus, moderately increased albuminuria was independently associated with AS and vascular inflammation [14] . However, limited data are available whether severely increased albuminuria is associated with AS in nondiabetic hypertensive patients already treated with renin angiotensin aldosterone blockade agents (RAAS) [15] . It has been suggested that endothelial dysfunction could be a possible mechanism involved in the remodeling of the arterial wall affecting AS and modifying glomerular permeability leading to increased albumin excretion [16,17] .…”