The Association of Alcohol Use Disorder and Chronic Plaque Psoriasis

Mahajan, Vikram K.; Dhattarwal, Niharika; Chauhan, Pushpinder S; Mehta, Karaninder S; Sharma, Reena; Sharma, Abha; Singh, Vijay K; Sharma, Jyotshna; Hooda, Sheenam

doi:10.4103/idoj.idoj_226_20

Cited by 7 publications

(6 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While smoking or drinking habit did not directly impact patients' quality of life in our finding, studies found that heavy smokers (more than 20 cigarettes per day) significantly increased the risk of severe psoriasis [22]. In addition, a study shows that 32.9% of drinkers had a higher risk of developing severe psoriasis compared to 67.1% of non-drinkers [23]. Further analysis needs to be performed to study the role of smoking and drinking habits in psoriasis patients' QoL.…”

Section: Psoriasis and Qolcontrasting

confidence: 47%

Exploring the Effectiveness of Biological Therapy in Patients with Psoriasis: Body Image and Quality of Life

Wu,

Chang,

Yao

et al. 2024

Medicina

View full text Add to dashboard Cite

Background and Objectives: Psoriasis is a chronic, long-term, incurable skin inflammatory disease characterized by the excessive proliferation of epidermal keratinocytes, dilation of blood vessels, thickening of the skin, and the formation of visible red patches of variable sizes. The impact on patients differs with the severity of the disease, leading to physiological discomfort and psychological distress, which significantly affect the quality of life. The etiology of psoriasis is not completely clear, but immune cells, including type 1 and type 17 cytokine-producing cells modulated by regulatory T cells (Tregs), play a critical role in driving the disease pathogenesis. With the ability to specifically target inflammatory markers, biologics can efficiently inhibit the spread of inflammation to achieve therapeutic effects. The goal was to explore the changes in body image and quality of life in psoriasis patients undertaking therapies with biologic agents. Materials and Methods: This study employed a quasi-experimental, single-sample, pretest–posttest design. Forty-four psoriasis patients were recruited from the dermatology outpatient clinics at two medical centers in northern Taiwan. A structured questionnaire, including demographic information, the Body Image Scale (BIS), and the Dermatology Life Quality Index (DLQI), was used as a research tool. Questionnaire assessments were conducted both before and three months after the biologic agent intervention. Statistical analyses were performed using SPSS version 22.0. Results: Our results indicated a significant difference in body image between psoriasis patients before and after intervention with biologic agents. In addition, overall quality of life (QoL) also showed significant improvements before and after biologic agent intervention. There was a positive correlation between body image and quality of life in psoriasis patients. Conclusions: The treatment for psoriasis has evolved rapidly in recent years, and biologic agents have proven to be effective therapies to improve the quality of life for psoriasis patients. Our study suggests that health-related education and psychological support can further benefit psoriasis patients to willingly and positively undertake treatment and therefore improve their positive body image and quality of life.

show abstract

Section: Psoriasis and Qolcontrasting

confidence: 47%

Exploring the Effectiveness of Biological Therapy in Patients with Psoriasis: Body Image and Quality of Life

Wu,

Chang,

Yao

et al. 2024

Medicina

View full text Add to dashboard Cite

show abstract

“…These findings were confirmed by a study ofn 146 patients with psoriasis evaluating alcohol consumption using the Alcohol Use Disorder Identification Test (AUDIT) questionnaire [96]. In that study, regular drinkers (AUDIT score > 8) had more severe psoriasis than patients with an AUDIT score < 8 (p < 0.05) [96]. Furthermore, a study conducted on 95 patients with psoriasis, which investigated the link between alcohol consumption and psychological distress, also found a modest but significant association between psoriasis severity and weekly alcohol consumption (r = 0.27, p = 0.02) [97].…”

Section: Alcohol Abstinencementioning

confidence: 72%

“…As to the former aspect, a study on study on 29 patients with moderate plaque psoriasis found that alcohol consumption evaluated through questionnaires and an alcohol-specific blood biomarker (i.e., phosphatidylethanol) correlated significantly with the PASI score [95]. These findings were confirmed by a study ofn 146 patients with psoriasis evaluating alcohol consumption using the Alcohol Use Disorder Identification Test (AUDIT) questionnaire [96]. In that study, regular drinkers (AUDIT score > 8) had more severe psoriasis than patients with an AUDIT score < 8 (p < 0.05) [96].…”

Section: Alcohol Abstinencementioning

confidence: 85%

Managing the Patient with Psoriasis and Metabolic Comorbidities

Bellinato,

Maurelli,

Geat

et al. 2024

Am J Clin Dermatol

View full text Add to dashboard Cite

Epidemiological data demonstrate strong associations between psoriasis and metabolic comorbidities, including obesity, hypertension, diabetes mellitus, dyslipidemia, and non-alcoholic fatty liver disease. The presence of metabolic comorbidities significantly influences the selection and effectiveness of pharmacological treatments. Some drugs should be prescribed with caution in patients with metabolic comorbidities because of an increased risk of adverse events, while others could have a reduced effectiveness. The aim of this narrative review is to highlight the challenges that healthcare professionals may face regarding the management of psoriasis in patients with metabolic comorbidities. In the first part of the article, the epidemiological association between psoriasis and metabolic comorbidities and their pathogenetic mechanisms is summarized. The second part describes the efficacy and safety profile of conventional and biologic drugs in patients with selected metabolic comorbidities including obesity, non-alcoholic fatty liver disease/hepatic steatosis, and diabetes. Finally, the role of pharmacological and non-pharmacological interventions, such as diet, alcohol abstinence, physical activity, and smoking avoidance is discussed. In conclusion, the choice of the best approach to manage patients with psoriasis with metabolic comorbidities should encompass both tailored pharmacological and individualized non-pharmacological interventions.

show abstract

“…Another 67.1% of patients abstained entirely from alcohol consumption (AUDIT score 0). The remaining 13% regularly drank (AUDIT score ≥8) and had a more severe disease course compared to abstainers ( P <0.05) [ 54 ]. An important limitation of Mahajan et al’s study was that some individuals, especially women, might have feared the stigma associated with disclosing their alcohol use, and the study lacked follow-up with respondents after they had reduced their intake or given up alcohol [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Alcohol Intake, Smoking, and Diet Evaluated Using the Alcohol Use Disorder Identification Test Questionnaire on the Severity of Plaque Psoriasis in 44 Patients Using the Body Surface Area and Psoriasis Area and Severity Index Scales, and Quality of Life Using the Dermatology Life Quality Index Questionnaire

Michalski¹,

Palazzo-Michalska²,

Michalska-Bańkowska³

et al. 2023

Med Sci Monit

View full text Add to dashboard Cite

Background This study aimed to evaluate the effects of alcohol intake, assessed using the Alcohol Use Disorder Identification Test (AUDIT) questionnaire, on the severity of plaque psoriasis using the Body Surface Area (BSA) and Psoriasis Area and Severity Index (PASI) scales, and quality of life using the Dermatology Life Quality Index (DLQI) questionnaire. Material/Methods The diagnosis of psoriasis was made based on the clinical picture. We enrolled 24 patients with psoriasis vulgaris, and the AUDIT test conducted at the time of follow-up indicated a possible risky/harmful pattern of alcohol consumption or alcohol dependence syndrome among the patients (>8 points). The comparison group consisted of 20 psoriatic patients and AUDIT <8 points. The BSA and PASI scales were used to determine the severity of psoriasis, and the DLQI questionnaire assessed patients’ quality of life and how they felt during the week preceding the survey. Results As the amount and frequency of alcohol consumed increased, the exacerbation of lesions measured according to the PASI and BSA scales was significantly higher ( P <0.05), and the quality of life decreased ( P <0.05). We noted that inadequate and excessive dietary intake of total protein, total fat, and assimilable carbohydrates were associated with statistically significantly higher values of BSA and PASI scores and, thus, more severe psoriatic lesions ( P <0.05). Conclusions An unbalanced diet, alcohol abuse, and smoking negatively affect the course of psoriasis vulgaris, hence the importance of patient education.

show abstract

The Association of Alcohol Use Disorder and Chronic Plaque Psoriasis

Cited by 7 publications

References 33 publications

Exploring the Effectiveness of Biological Therapy in Patients with Psoriasis: Body Image and Quality of Life

Exploring the Effectiveness of Biological Therapy in Patients with Psoriasis: Body Image and Quality of Life

Managing the Patient with Psoriasis and Metabolic Comorbidities

Contact Info

Product

Resources

About