The association of amyloid deposits and osteoarthritis

Egan, Michael S.; Goldenberg, Don L.; Cohen, Alan S.; Segal, David

doi:10.1002/art.1780250214

Cited by 37 publications

(14 citation statements)

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“…[17][18][19][20][21][22][23] Recently, intervertebral disc tissue from mice and from surgically removed human discs has been investigated systematically for amyloid deposit.3 4 24 One of us has found amyloid in 93% of vertebral columns from 30 non-selected autopsies.25 Only 41% of the herniated discs in the present study were positive for amyloid. The two studies are not comparable, however, because much more tissue was available for examination in the autopsy study.…”

Section: Discussionmentioning

confidence: 75%

Amyloid in intervertebral discs: a histopathological investigation of surgical material from 100 consecutive operations on herniated discs.

Ladefoged¹,

Fedders²,

Petersen³

1986

Annals of the Rheumatic Diseases

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SUMMARY Material from 100 consecutive operations on herniated discs has been investigated for amyloid. Various degrees of amyloid degeneration were found in disc tissue from 41 patients. Material from patients over 50 years old showed significantly more amyloid than that from younger patients; there was no sex difference. Eighteen patients had previously been operated on for herniated discs; seven of these (39%) had pyrophosphate deposits in their disc tissue, often in close topographical relation to amyloid. 26% of the patients had calcium phosphate deposits and 29% had slight inflammation-both without relation to amyloid. No pathogenetic correlation between amyloid degeneration and herniation of intervertebral disc tissue could be shown.Amyloid deposits in intervertebral discs were first described by Bywaters and Dorling in 1970' in a patient with myelomatosis and amyloid in several organs and joints. Amyloid in disc tissue has also been described in association with severe primary amyloidosis.2 More recently, amyloid has been described in tissue from surgically removed herniated intervertebral discs.3 4 One of us (CL) has just shown a very high incidence of amyloid degeneration of the vertebral column in a consecutive series of non-selected autopsies.The object of the present investigation has been to ascertain the occurrence of amyloid in tissue from 100 consecutive operations on herniated discs and to relate the findings to age, previous surgery on the vertebral column, and to other histopathological changes. Materials and methodsTissue from 100 consecutive operations on herniated discs performed at the neurosurgical department, Odense University Hospital were studied by light microscopy and electron microscopy.Immediately after operation all the removed tissue was fixed in 10% formalin for at least 24

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Section: Discussionmentioning

confidence: 75%

Amyloid in intervertebral discs: a histopathological investigation of surgical material from 100 consecutive operations on herniated discs.

Ladefoged¹,

Fedders²,

Petersen³

1986

Annals of the Rheumatic Diseases

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“…Sørenson and Christensen (1973) found local amyloid deposition in the hip joint capsule in patients with OA, which was related to tissue degeneration. Egan et al (1982) made a new observation that amyloid was often located at the articular cartilage surface of osteoarthritic knees or hips. Thereafter, Ladefoged (1983) described amyloid deposits in the articular capsule from osteoarthritic hip joints associated with secondary chondromatosis, pyrophosphate deposits, and inflammatory cell infiltration.…”

Section: Introductionmentioning

confidence: 99%

Clinical and laboratory characteristics of patients having amyloidogenic transthyretin deposition in osteoarthritic knee joints

et al. 2014

J. Zhejiang Univ. Sci. B

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Objective: Our aim was to investigate clinical and laboratory characteristics of osteoarthritic patients who had amyloid deposition in their knee joints. Methods: Synovial membranes were obtained from 36 patients with knee osteoarthritis (OA) who underwent joint replacement surgery. From this sample, the diagnosis of amyloid was determined by Congo red staining, which demonstrated apple-green birefringence under a polarized microscope. All synovial membranes were immunohistochemically characterized for the expressions of amyloid immunoglobulin light chain (AL-κ and AL-λ), serum amyloid-A (SAA), amyloidogenic transthyretin (ATTR), and amyloidogenic β2-microglobulin (Aβ2M). Matrix-assisted laser desorption-ionizaton/time of flight mass spectrometry (MALDI-TOF MS) was used to analyze transthyretin (TTR) isoforms in the serum of each patient. Results: Nine cases (25%) were found to be amyloid-positive. Immunohistochemically, eight cases (88.9%) had ATTR deposition, and one sample (11.1%) was shown to be AL-κ-positive. MALDI-TOF MS identified that the TTR in the serum of the patients was unmodified wild-type TTR, TTR-Cys-S-S-Cys, and TTR-Cys-S-S-CysGly. The age at surgery and the disease duration were significantly higher in the ATTR-positive group than in the ATTR-negative group. Knee score and function score were significantly lower in the ATTR-positive group than in the ATTR-negative group. Conclusions: Amyloid deposition in synovial membranes of OA patients was found to be ATTR and AL-κ. TTR in the serum of the patients was unmodified wild-type TTR together with two isoforms. The high age at surgery, long disease duration, and a deteriorated knee function were associated with ATTR amyloid deposition in the osteoarthritic knee joints.

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“…Michaels et al (1) note that the carcinogenic potential of methotrexate is minimal (2)(3)(4). This difference supports the choice of methotrexate when an immunosuppressant, cytotoxic drug is indicated.…”

Section: To the Editormentioning

confidence: 96%