The association of annexin A2 and cancers

Abstract

Annexins are a group of calcium- and phospholipid-dependent proteins. As a member of the annexin, annexin A2 (Anxa2) is widely distributed in nucleus, cytoplasm and extracellular surface and mainly expressed in human endothelial cells, mononuclear cells, macrophages, marrow cells and some tumor cells. Accumulated evidences indicated that Anxa2 deregulation was associated with the occurrence, invasion and metastasis of cancers. Anxa2 up-regulation was related to the development, invasion, metastasis and drug resistance of hepatocellular carcinoma, colorectal cancer, breast cancer, pancreatic cancer, acute promyelocytic leukemia and renal cell carcinoma; while Anxa2 down-regulation was associated with prostate cancer, esophageal squamous carcinoma and nasopharyngeal carcinoma and sinonasal adenocarcinoma. The association between Anxa2 and malignant tumors as well as the potential action mechanisms were summarized in current work. Anxa2 might be used as a potential biomarker for the diagnosis, treatment and prognosis of certain tumors.

Annexin A2 is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer

“…Furthermore, it has been suggested that Annexin A2 may be used as a potential biomarker for the diagnosis, treatment and prognosis of tumors (18). Zhang et al (18) reported that the soluble Annexin A2 concentration detected by ELISA in serum samples from 42 patients with lung cancer was significantly higher than in 43 healthy individuals.…”

H3K9 Histone Methyltransferase, KMT1E/SETDB1, Cooperates with the SMAD2/3 Pathway to Suppress Lung Cancer Metastasis

“…In cancer cells, abnormal expression of ANXA2 has been associated with cancer progression and metastasis (17,(36)(37)(38). One study has indicated that ANXA2 promotes cancer cell migration and invasion via F-actin polymerization change of the microstructures in cancer cells (39).…”

“…ANXA2 is a direct and functional target of KMT1E in lung cancer cell metastasis Previous studies have shown that the calcium-dependent phospholipid-binding protein ANXA2 plays a role in F-actin polymerization (24) and cancer metastasis (17). To examine whether ANXA2 plays a role in lung cancer, we performed Factin staining and in vitro invasion assays.…”

“…It is known that the calcium-dependent phospholipid-binding protein ANXA2 plays a role in cytoskeletal rearrangement (16) and cancer metastasis (17). More recent studies showed that ANXA2 was highly expressed and positively correlated with a poor prognosis in non-small cell lung cancer (18).…”

Gender and Age Related Modulation of Xenoestrogen-Induced Tumorigenesis

“…The combined exposure of prepubertal rats to Bisphenol A and genistein increases annexin A2 levels in mammary gland by 73%, whereas genistein alone decreases it by 67% [8]. It is known that both increased and decreased levels of annexin A2 increase cancer risk [38,8,39]. Environmental mixtures of EDC which affect different pathways are difficult to investigate with standard toxicology methods; however, the use of bioinformatics and systems biology may dramatically improve risk assessment of combine exposures [40].…”