2016
DOI: 10.1007/s00408-016-9894-z
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The Association of Brain-Derived Neurotrophic Factor Gene Polymorphism with Obstructive Sleep Apnea Syndrome and Obesity

Abstract: In conclusion, BDNF 196G/A genotype was found to be more frequent among obese patients compared to the non-obese individuals, but it was not significantly related to OSAS in the present study. BDNF196G/G genotype was more common and BDNF 196G/A polymorphism was less common among OSAS+ obesity- subjects compared to the other study groups.

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Cited by 5 publications
(5 citation statements)
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“…No significant differences were observed regarding the BDNF (rs6265) polymorphism between patients with and without OSA, and there was also no significant association with the BDNF gene and OSA polymorphism in a regression analysis. In our study, unlike the study by Yüksekkaya et al 21 , age and BMI did affect the results, since BDNF 270C/T was significantly associated with OSA in a codominant, dominant, recessive, and log-additive model, although after adjusting for age and BMI there was no longer a significant association with OSA.…”
Section: Discussioncontrasting
confidence: 99%
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“…No significant differences were observed regarding the BDNF (rs6265) polymorphism between patients with and without OSA, and there was also no significant association with the BDNF gene and OSA polymorphism in a regression analysis. In our study, unlike the study by Yüksekkaya et al 21 , age and BMI did affect the results, since BDNF 270C/T was significantly associated with OSA in a codominant, dominant, recessive, and log-additive model, although after adjusting for age and BMI there was no longer a significant association with OSA.…”
Section: Discussioncontrasting
confidence: 99%
“…Although the evidence points to the possibility of changes in the BDNF and PER3 genes being relevant for the development of OSA 21-23 , the type of analysis carried out in the present study did not support the notion of such an association. These results may be due to the fact that there is indeed no relationship between the specific BDNF and PER3 gene polymorphisms and OSA.…”
Section: Discussioncontrasting
confidence: 92%
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