The Association of Cardiovascular Disorders and Falls: A Systematic Review

Jansen, Sanne; Bhangu, Jaspreet; Rooij, Sophia E. de; Daams, Joost G.; Kenny, Rose Anne; Velde, Nathalie van der

doi:10.1016/j.jamda.2015.08.022

Cited by 110 publications

(73 citation statements)

References 26 publications

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“…Even though some studies have described an increase in CVD risk compared with the general population[20-22], this has not been the case in other reports[4,23]. A group of CD patients, retrospectively studied in comparison with data from general population[24], showed less CVD risk employing the Framingham score.…”

Section: Discussionmentioning

confidence: 96%

Markers of inflammation and cardiovascular disease in recently diagnosed celiac disease patients

Tetzlaff¹,

Meroño²,

Menafra³

et al. 2017

WJC

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AIMTo evaluate novel risk factors and biomarkers of cardiovascular disease in celiac disease (CD) patients compared with healthy controls.METHODSTwenty adult patients with recent diagnosis of CD and 20 sex, age and body mass index-matched healthy controls were recruited during a period of 12 mo. Indicators of carbohydrate metabolism, hematological parameters and high sensitive C reactive protein were determined. Moreover, lipoprotein metabolism was also explored through evaluation of the lipid profile and the activity of cholesteryl ester transfer protein and lipoprotein associated phospholipase A2, which is also considered a specific marker of vascular inflammation. The protocol was approved by the Ethic Committee from School of Pharmacy and Biochemistry, University of Buenos Aires and from Buenos Aires Italian Hospital, Buenos Aires, Argentina.RESULTSRegarding the indicators of insulin resistance, CD patients showed higher plasma insulin levels [7.2 (5.0-11.3) mU/L vs 4.6 (2.6-6.7) mU/L, P < 0.05], increased Homeostasis Model Assessment-Insulin Resistance [1.45 (1.04-2.24) vs 1.00 (0.51-1.45), P < 0.05] and lower Quantitative Sensitive Check index [0.33 (0.28-0.40) vs 0.42 (0.34-0.65), P < 0.05] indexes. Folic acid concentration [5.4 (4.4-7.9) ng/mL vs 12.2 (8.0-14.2) ng/mL, P < 0.01] resulted to be lower and High-sensitivity C reactive protein levels higher (4.21 ± 6.47 mg/L vs 0.98 ± 1.13 mg/L, P < 0.01) in the patient group. With respect to the lipoprotein profile, CD patients showed lower high density lipoprotein-cholesterol (HDL-C) (45 ± 15 mg/dL vs 57 ± 17 mg/dL, P < 0.05) and apo A-I (130 ± 31 mg/dL vs 155 ± 29 mg/dL, P < 0.05) levels, as well as higher total cholesterol/HDL-C [4.19 (3.11-5.00) vs 3.52 (2.84-4.08), P < 0.05] and apo B/apo A-I (0.75 ± 0.25 vs 0.55 ± 0.16, P < 0.05) ratios in comparison with control subjects. No statistically significant differences were detected in lipoprotein-associated lipid transfer protein and enzymes.CONCLUSIONThe presence and interaction of the detected alterations in patients with CD, would constitute a risk factor for the development of atherosclerotic cardiovascular disease.

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Section: Discussionmentioning

confidence: 96%

Markers of inflammation and cardiovascular disease in recently diagnosed celiac disease patients

Tetzlaff¹,

Meroño²,

Menafra³

et al. 2017

WJC

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“…There were 14 (28%) major arrhythmias detected at the time of a subsequent fall which resulted in prompt, ILR guided intervention. Previous observational studies have shown a prevalence between 1% and 25% for detection of cardiac arrhythmia in older fallers 26. They differed significantly in their methods, definitions of cardiac arrhythmia and the ways in which they had captured arrhythmia.…”

Section: Discussionmentioning

confidence: 99%

Long-term cardiac monitoring in older adults with unexplained falls and syncope

Bhangu

McMahon

Hall

et al. 2016

Heart

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“…Low blood pressure, intermittent arrhythmia and heart failure have all shown associations with falls risk in epidemiological studies[31]. Observational studies also support the link between cardiovascular disease and NAF with higher rates of cardiac arrhythmia and carotid sinus syndrome in participants who report NAF[32, 33].…”

Section: Discussionmentioning

confidence: 99%

Falls, non-accidental falls and syncope in community-dwelling adults aged 50 years and older: Implications for cardiovascular assessment

et al. 2017

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ObjectivesTo calculate the prevalence of all falls, non-accidental falls and syncope in an older population and characterize cardiovascular risk profiles.DesignProspective, longitudinal cohort study.SettingThe first two waves of data from the Irish Longitudinal Study on Ageing (TILDA).Participants8172 community-dwelling adults aged 50 years and older resident in the Republic of IrelandMeasurementsSelf-reported history of all falls, non-accidental falls and syncope in the year preceding the first two waves of data collection. Demographic factors and self-reported cardiovascular conditions were used to characterize cardiovascular risk profiles.ResultsThe prevalence of all falls in the past year was 19.2% or 192 per thousand persons and increased with age (50–64 years 17.5%; 65–74 years 19.4%; 75+ years 24.4%). Non-accidental falls had an estimated prevalence of 5.1% or 51 falls per thousand persons and accounted for 26.5% of all falls reported and also increased with age (50–64 years 4.0%; 65–74 years 5.5%; 75+ years 8.0%). The prevalence for syncope was estimated to be 4.4% or 44per thousand persons but did not show a similar age gradient. Participants with at least 5 cardiovascular conditions were more likely to report all falls (OR = 2.07, 95% CI 1.18–3.64, p<0.05) and NAF (OR = 2.89, 95%CI 1.28–6.52, p<0.05).ConclusionsThe prevalence of all falls and non-accidental falls increases with age but the same pattern was not consistently observed for syncope. There is an increased odds of reporting all three outcomes with increasing number of self-reported cardiovascular conditions. Further work is needed to uncover the interplay between cardiovascular disease and subsequent falls.

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The Association of Cardiovascular Disorders and Falls: A Systematic Review

Cited by 110 publications

References 26 publications

Markers of inflammation and cardiovascular disease in recently diagnosed celiac disease patients

Markers of inflammation and cardiovascular disease in recently diagnosed celiac disease patients

Long-term cardiac monitoring in older adults with unexplained falls and syncope

Falls, non-accidental falls and syncope in community-dwelling adults aged 50 years and older: Implications for cardiovascular assessment

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