The Association of Chlamydia pneumoniae Infection and Reactive Airway Disease in Children

Emre, Umit; Roblin, Patricia M.; Gelling, Maureen; Dumornay, Wilson; Rao, Madu; Hammerschlag, Margaret R.; Schachter, Julius

doi:10.1001/archpedi.1994.02170070065013

Cited by 223 publications

(146 citation statements)

References 15 publications

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“…In agreement with previous reports, the present results also show that, in children with wheezing, the incidence of acute M. pneumoniae and C. pneumoniae infection increases with age and occurs mainly after 5 yrs of age [8,9]. Moreover, in the present study population, the incidence of asymptomatic infection in healthy subjects seemed to be low and was similar to that recently reported in adults [23,24].…”

Section: Discussionsupporting

confidence: 93%

“…Previous studies have demonstrated the efficacy of macrolides in the treatment of atypical bacterial infections in children with community-acquired pneumonia [15,16]. EMRE et al [8] observed that nine of 12 children with asthma and positive cultures for C. pneumoniae demonstrated clinical and laboratory improvement of their symptoms following antibiotic therapy with clarithromycin for 10 days or erythromycin for 14 days. However, in children with wheezing, the efficacy of antibiotic treatment and the optimal length of therapy have not been established.…”

Section: Discussionmentioning

confidence: 99%

“…Few data are available regarding childhood [8,9]. The aim of the present study was to evaluate the role of M. pneumoniae and C. pneumoniae in paediatric patients with reactive airway disease.…”

mentioning

confidence: 98%

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Importance of acute Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with wheezing

Esposito¹,

Blasi²,

Arosio³

et al. 2000

Eur Respir J

181

130

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In order to evaluate the role of Mycoplasma pneumoniae and Chlamydia pneumoniae in reactive airway disease, 71 children aged 2±14 yrs with an acute episode of wheezing and 80 age-matched healthy children were studied.Sera for the determination of specific antibody levels and nasopharyngeal aspirates for the detection of M. pneumoniae and C. pneumoniae deoxyribonucleic acid were obtained on admission and after 4±6 weeks. All children with wheezing received a standard therapy with inhaled corticosteroids and bronchodilators for 5±7 days; when antibiotic was added on the basis of the judgement of the paediatrician in charge, clarithromycin 15 mg . kg body weight -1 . day -1 for 10 days was used.Acute M. pneumoniae and C. pneumoniae infections were detected significantly more often in children with wheezing than in controls. In patients infected with one of the two pathogens, a history of recurrent wheezing was significantly more frequent than in those without either infection. During a 3-month follow-up period, among nonantibiotic-treated children, those with acute M. pneumoniae and/or C. pneumoniae infection showed a significantly higher recurrence of wheezing than those without acute M. pneumoniae and/or C. pneumoniae infection (p=0.03).These results highlight the apparently significant relationship of Mycoplasma pneumoniae and Chlamydia pneumoniae with wheezing in children, particularly in subjects with a history of recurrent episodes, and the possible improvement in the course of reactive airway disease within paediatric patients with acute Mycoplasma pneumoniae and/or Chlamydia pneumoniae infection.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Importance of acute Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with wheezing

Esposito¹,

Blasi²,

Arosio³

et al. 2000

Eur Respir J

181

130

View full text Add to dashboard Cite

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“…Carrier state has been considerably described by culture and more recently by PCR. In one report 4.7% of 234 healthy adults [22] and 2 of 41 healthy children [23] had TWAR isolated from throat cultures. Others identified TWAR by PCR or nasopharingeal culture in 2 of 104 healthy adults [24].…”

Section: Discussionmentioning

confidence: 98%

Community-acquired pneumonia by Chlamydophila pneumoniae: a clinical and incidence study in Brazil

Chedid¹,

Chedid²,

Ilha³

et al. 2007

Braz J Infect Dis

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As there was not any data on Chlamydia pneumoniae (TWAR) infections in Brazil so far, a prospective cohort study of adult patients hospitalized due to CAP was carried out for one year in a Brazilian university general hospital to detect the incidence of CAP by Chlamydophila pneumoniae (TWAR) for one year. During a whole year 645 consecutive patients hospitalized due to an initial presumptive diagnosis of respiratory diseases by ICD-10 (J00-J99), excluding upper respiratory diseases, were screened; 59 consecutive patients with CAP were diagnosed. They had determinations of serum antibodies to C. pneumoniae by microimmunofluorescence at the Infectious Diseases Laboratory of University of Louisville (KY, USA); 37 patients (63.8%) had seroreactivity to TWAR antigens, from which 23 (39.6%) had previous infection; 3 patients (5.2%) were diagnosed with CAP by TWAR and got cured. The incidence of TWAR CAP in our hospital by seroconversion was 5.2%. Our incidence of 5.2% is probably underestimated since TWAR culture was not available; we suggest that Real-Time PCR be used along with other diagnostic methods in future studies to detect the actual incidence of TWAR CAP. We propose that the serological criterion of IgM ≥1:16 alone to the diagnosis of acute infection by TWAR are discontinued due a lack of specificity.

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“…The association was first described by Hahn et al, who reported wheezing in 9 out of 19 adult patients with serologic evidence of current or recent C. pneumoniae infection 2 . In another study 11 % asthmatic and 5 % control children found to have positive cultures for C. pneumoniae 3 . Although some results were controversial, several studies confirmed these findings 4,5,6 .…”

Section: Introductionmentioning

confidence: 92%

Bronchial asthma and Chlamydia pneumoniae antibodies in children aged 4-8 years in Olomouc district

Kopřiva¹,

Szotkowská²,

Zápalka³

2005

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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BACKGROUND. Although several studies have demonstrated an association between infection with Chlamydia pneumoniae and asthma, these were mainly limited to exacerbation of symptoms in adults with known asthma OBJECTIVE. We investigated the role of C. pneumoniae infection in l49 atopic children with chronic cough and asthma, comparing them with 241 control non-atopic subjects presenting at Olomouc hospital between 1999 and 2003 with non-specific symptoms (temperature above normal (subfebrile), abdominal pain, arthralgia, and other symptoms.METHODS. The levels of C. pneumoniae-specific antibodies were measured using Chlamydien-rELISA kits (Medac, Hamburg, Germany).RESULTS. In a group of 83 atopic children with chronic cough, IgM and IgG antibodies to C. pneumoniae were demonstrated in 20 children (24 %). Among children with bronchial asthma, positive antibody was present in 29 children (44 %; /p = 0,052/); of this number, 24 (36 %; /p = 0,06/) had IgM and IgG antibodies while 5 children (8 %) had IgA and IgG antibodies against C. pneumoniae. A group of non-atopic children with non-specific symptoms included 38 children (16 %) with antibody positivity; 27 children (11 %) with IgM and IgG antibodies and 11 children (5 %) with IgA and IgG antibodies against C. pneumoniae.CONCLUSIONS. Asthma in children was associated with elevated levels of IgM and IgG antibodies to C. pneumoniae.

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The Association of Chlamydia pneumoniae Infection and Reactive Airway Disease in Children

Cited by 223 publications

References 15 publications

Importance of acute Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with wheezing

Importance of acute Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with wheezing

Community-acquired pneumonia by Chlamydophila pneumoniae: a clinical and incidence study in Brazil

Bronchial asthma and Chlamydia pneumoniae antibodies in children aged 4-8 years in Olomouc district

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