The Association of Circulatory Cytokines (IL-6 and IL-10) Level with Spontaneous Abortion—a Preliminary Observation

Thaker, Riddhi; Oza, Hina; Verma, V. K.; Gor, Mansi; Kumar, Sunil

doi:10.1007/s43032-020-00292-6

Cited by 12 publications

(11 citation statements)

References 18 publications

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“…Cell-specific responses to chemical stressors were observed in our studies; the DEC consistently produced higher IL-6 regardless of exposure type, mimicking other reported pregnancy pathologies. 101,102 This indicates a localized disturbance and nonspecific inflammatory environment on the maternal side, that may act as a sensor of an insult. 103,104 Conversely, on the fetal side, STBs and STRs act as main players in providing anti-inflammatory signals, as observed in other systems [105][106][107][108] while endothelial cells promote epithelial integrity to prevent leakage of inflammatory mediators across the compartments.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Endocrine-disrupting compounds and their impact on human placental function: evidence from placenta organ-on-chip studies

Vidal,

Richardson,

Kumar Kammala

et al. 2024

Lab Chip

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Endocrine-disrupting compounds and their impact on human placental function: evidence from placenta organ-on-chip studies

Vidal,

Richardson,

Kumar Kammala

et al. 2024

Lab Chip

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“…This cytokine plays a key regulatory role in immune tolerance at the placental barrier during pregnancy to balance proinflammatory and anti-inflammatory signals and promote better pregnancy outcomes [ 65 , 66 ]. The third trimester is the maternal proinflammatory phase, and low levels of IL-10 due to diet may induce adverse pregnancy outcomes such as miscarriage, recurrent miscarriage, preterm delivery, and preeclampsia [ 66 , 67 , 68 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between the Dietary Inflammatory Index Score and Cytokine Levels in Chinese Pregnant Women during the Second and Third Trimesters

et al. 2022

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The impact of dietary inflammatory potential on serum cytokine concentrations in second and third trimesters of Chinese pregnant women is not clear. A total of 175 pregnant women from the Tianjin Maternal and Child Health Education and Service Cohort (TMCHESC) were included. The dietary inflammatory index (DII) was calculated based on 24-h food records. Serum tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β), IL-6, IL-8, IL-10, C-reactive protein (CRP), and monocyte chemoattractant protein-1 (MCP-1) levels in the second and third trimesters were measured. The mean DII scores (mean ± SD) were −0.07 ± 1.65 and 0.06 ± 1.65 in the second and third trimesters, respectively. In the third trimester, IL-1β (p = 0.039) and MCP-1 (p = 0.035) levels decreased and then increased with increasing DII scores. IL-10 concentrations decreased in pregnant women whose DII scores increased between the second and third trimesters (p = 0.011). Thiamin and vitamin C were negatively correlated with MCP-1 (β = −0.879, and β = −0.003) and IL-6 (β = −0.602, and β = −0.002) levels in the third trimester. In conclusion, the DII score had a U-shaped association with cytokine levels during the third trimester. Changes in DII scores between the second and third trimesters of pregnancy were correlated with cytokine levels during the third trimester.

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“…Patients experiencing PL may exhibit altered systemic cytokine levels, compared to women having uneventful pregnancies, although the results are varying significantly. An increased IL-6 concentration in plasma [ 128 ] and serum [ 123 , 129 , 130 ], as well as greater expression in PBMCs [ 123 , 128 ], is found in SPL and RPL patients vs. controls. Unaltered [ 131 , 132 ] or decreased IL-6 levels in serum [ 133 , 134 , 135 , 136 ] of SPL and RPL patients are also shown.…”

Section: Il-6 and Il-8 In Selected Pregnancy Pathologiesmentioning

confidence: 99%

IL-6 and IL-8: An Overview of Their Roles in Healthy and Pathological Pregnancies

Vilotić

Nacka-Aleksić

Pirković

et al. 2022

IJMS

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Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action, mediating innate and adaptive immunity and multiple physiological processes, including protective and regenerative ones. IL-8 is a pro-inflammatory CXC chemokine with a primary function in attracting and activating neutrophils, but also implicated in a variety of other cellular processes. These two ILs are abundantly expressed at the feto-maternal interface over the course of a pregnancy and have been shown to participate in numerous pregnancy-related events. In this review, we summarize the literature data regarding their role in healthy and pathological pregnancies. The general information related to IL-6 and IL-8 functions is followed by an overview of their overall expression in cycling endometrium and at the feto-maternal interface. Further, we provide an overview of their involvement in pregnancy establishment and parturition. Finally, the implication of IL-6 and IL-8 in pregnancy-associated pathological conditions, such as pregnancy loss, preeclampsia, gestational diabetes mellitus and infection/inflammation is discussed.

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The Association of Circulatory Cytokines (IL-6 and IL-10) Level with Spontaneous Abortion—a Preliminary Observation

Cited by 12 publications

References 18 publications

Endocrine-disrupting compounds and their impact on human placental function: evidence from placenta organ-on-chip studies

Endocrine-disrupting compounds and their impact on human placental function: evidence from placenta organ-on-chip studies

Relationship between the Dietary Inflammatory Index Score and Cytokine Levels in Chinese Pregnant Women during the Second and Third Trimesters

IL-6 and IL-8: An Overview of Their Roles in Healthy and Pathological Pregnancies

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