The association of cognitive deficits with mental and physical Quality of Life in Major Depressive Disorder

Knight, Matthew J.; Lyrtzis, Ellen; Baune, Bernhard T.

doi:10.1016/j.comppsych.2019.152147

Cited by 41 publications

(33 citation statements)

References 42 publications

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“…It is known that medically unexplained neurologic symptoms are common (Evens et al, 2015) and the relatively high proportion of PwUD we found in this study compared with previous diagnostic surveys (Eriksson et al, 2019;Knight et al, 2020) might be due to a lower threshold for performing a diagnostic work-up in persons with onset symptoms suggestive of MS at our center. This study confirmed that the risk of CIS and MS in persons not fulfilling the diagnostic criteria at onset is low despite persistence of neurological symptoms (Boster et al, 2008).…”

Section: Tablecontrasting

confidence: 48%

“…Another limitation of this study was the absence of evalution of MS fatigue and tests to assess neuropsychiatric disorders such as anxiety or depression. In previous studies, fatigue was associated with depression and lower QoL in people with MS (Eriksson et al, 2019) and cognitive deficits due to depression resulted in reduced mental QoL (Knight et al, 2020). However, at reassessment the questionnaire revealed such disorders in only few persons and no obvious deviation of mental state was noted at the neurological examination.…”

Section: Tablementioning

confidence: 65%

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Persons with suspicious onset of multiple sclerosis but with undetermined diagnosis had persistent lower cognition and reduced quality of life

Constantinescu

Novakova

Brandt

et al. 2021

Multiple Sclerosis and Related Disorders

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Backgound: Differential diagnosis of multiple sclerosis (MS) includes a variety of disorders and misdiagnosis is common. Objective: To follow-up persons with suspected onset of MS but in whom the diagnostic investigation was negative. Methods: In a prospective study including 271 persons with clinical features of suspected MS onset, 136 persons were diagnosed with MS or clinically isolated syndrome (PwMS), 46 had other disorders, and 89 persons had a negative diagnostic work-up, i.e. persons with undetermined diagnosis (PwUD). They underwent diagnostic reassessment, and those who remained without a diagnosis were investigated for signs of pathology including cognitive tests and assessments of quality of life (QoL). Results were compared with those of PwMS and 24 age and sex matched healthy controls (HC). Results: After reassement 55 (20%) persons still had undetermined diagnosis (PwUD). They had similar age and gender distribution as PwMS. In 76% of PwUD, the suspected clinical onset included sensory symptoms. PwUD and PwMS scored similarly in cognitive tests and QoL but significantly lower than HC. At 3 years follow-up, PwMS and PwUD improved in most test parameters, but PwUD scored lower than PwMS in cognition. Conclusion: PwUD constituted the dominating differential diagnosis in persons with suspected clinical onset of MS. QoL and cognition were comparable with those of PwMS but significantly lower than in HC.

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Section: Tablecontrasting

confidence: 48%

Section: Tablementioning

confidence: 65%

Persons with suspicious onset of multiple sclerosis but with undetermined diagnosis had persistent lower cognition and reduced quality of life

Constantinescu

Novakova

Brandt

et al. 2021

Multiple Sclerosis and Related Disorders

View full text Add to dashboard Cite

show abstract

“…Approximately 20% of all depressed patients develop a chronic course (Kessler et al, 2003). Untreated depression is associated with a decreased quality of life (Gao et al, 2019;Tang et al, 2019;Knight et al, 2020), increased suicide risk (four times more than the general population), and progressively worse health when associated with chronic physical illnesses, etc (Moussavi et al, 2007;Daly et al, 2010). Comorbidity with other chronic conditions (diabetes, hypertension, cardiovascular diseases, and cancer, among others) is high (Cassano and Fava, 2002;Katon, 2003;O'Neil et al, 2015;Read et al, 2017;Zhang et al, 2018) as is the case with other psychiatric diseases such as anxiety disorders (40 to 66%) (Aragonès et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Factors Associated With Depressive Episode Recurrences in Primary Care: A Retrospective, Descriptive Study

et al. 2020

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Results: The average age of those suffering more than one depressive episode is significantly older (5 years), and a higher percentage of subjects who have experienced more than one depressive episode have a history of anxiety disorders. In the multivariate analysis, the variables that obtained a significant value in the logistic regression analysis were age (OR: 1.03; value: 0.007) and having suffered sexual abuse during childhood (OR: 1.64; value: 0.072). Conclusion: These indicators should be considered by primary care physicians when attending patients suffering from major depression.

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“…Despite the wide profile of cognitive dysfunctions characterizing MDD, sex differences in cognitive performances and in the underlying functional brain networks remain largely unexplored. The cognitive domain of inhibitory control is receiving special interest, since it appears to be greatly affected by the MDD pathology and to impact on the therapeutical and functional outcomes (33)(34)(35)(36)(37).…”

Section: Introductionmentioning

confidence: 99%

Sexual Dimorphism in the Brain Correlates of Adult-Onset Depression: A Pilot Structural and Functional 3T MRI Study

et al. 2022

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Major Depressive Disorder (MDD) is a disabling illness affecting more than 5% of the elderly population. Higher female prevalence and sex-specific symptomatology have been observed, suggesting that biologically-determined dimensions might affect the disease onset and outcome. Rumination and executive dysfunction characterize adult-onset MDD, but sex differences in these domains and in the related brain mechanisms are still largely unexplored. The present pilot study aimed to explore any interactions between adult-onset MDD and sex on brain morphology and brain function during a Go/No-Go paradigm. We hypothesized to detect diagnosis by sex effects on brain regions involved in self-referential processes and cognitive control. Twenty-four subjects, 12 healthy (HC) (mean age 68.7 y, 7 females and 5 males) and 12 affected by adult-onset MDD (mean age 66.5 y, 5 females and 7 males), underwent clinical evaluations and a 3T magnetic resonance imaging (MRI) session. Diagnosis and diagnosis by sex effects were assessed on regional gray matter (GM) volumes and task-related functional MRI (fMRI) activations. The GM volume analyses showed diagnosis effects in left mid frontal cortex (p < 0.01), and diagnosis by sex effects in orbitofrontal, olfactory, and calcarine regions (p < 0.05). The Go/No-Go fMRI analyses showed MDD effects on fMRI activations in left precuneus and right lingual gyrus, and diagnosis by sex effects on fMRI activations in right parahippocampal gyrus and right calcarine cortex (p < 0.001, ≥ 40 voxels). Our exploratory results suggest the presence of sex-specific brain correlates of adult-onset MDD–especially in regions involved in attention processing and in the brain default mode–potentially supporting cognitive and symptom differences between sexes.

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The association of cognitive deficits with mental and physical Quality of Life in Major Depressive Disorder

Cited by 41 publications

References 42 publications

Persons with suspicious onset of multiple sclerosis but with undetermined diagnosis had persistent lower cognition and reduced quality of life

Persons with suspicious onset of multiple sclerosis but with undetermined diagnosis had persistent lower cognition and reduced quality of life

Factors Associated With Depressive Episode Recurrences in Primary Care: A Retrospective, Descriptive Study

Sexual Dimorphism in the Brain Correlates of Adult-Onset Depression: A Pilot Structural and Functional 3T MRI Study

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