The association of cytosol oestrogen and progesterone receptors with histological features of breast cancer and early recurrence of disease

The purpose of this study was to classify breast carcinomas based on variations in gene expression patterns derived from cDNA microarrays and to correlate tumor characteristics to clinical outcome. A total of 85 cDNA microarray experiments representing 78 cancers, three fibroadenomas, and four normal breast tissues were analyzed by hierarchical clustering. As reported previously, the cancers could be classified into a basal epithelial-like group, an ERBB2-overexpressing group and a normal breast-like group based on variations in gene expression. A novel finding was that the previously characterized luminal epithelial͞estrogen receptorpositive group could be divided into at least two subgroups, each with a distinctive expression profile. These subtypes proved to be reasonably robust by clustering using two different gene sets: first, a set of 456 cDNA clones previously selected to reflect intrinsic properties of the tumors and, second, a gene set that highly correlated with patient outcome. Survival analyses on a subcohort of patients with locally advanced breast cancer uniformly treated in a prospective study showed significantly different outcomes for the patients belonging to the various groups, including a poor prognosis for the basal-like subtype and a significant difference in outcome for the two estrogen receptor-positive groups.

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“…Thus, because of their internal correlations in multivariate analysis, the prognostic value of many of these parameters fades away (9,10).…”

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confidence: 99%

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

Sørlie

Perou

Tibshirani

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

9,742

266

8,142

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“…In an effort to explain this, and perhaps also improve selection of these patients, the association between oestrogen receptors and a variety of other biological parameters has been investigated, e.g. cell cycle kinetics (Meyer et al, 1984), histological tumour typing and grading (Howat et al, 1983;Mossler et al, 1980;Underwood, 1983) and nuclear ploidy. In general, these studies have shown that variables associated with poor prognosis in breast cancer appear to be associated more frequently with an absence of oestrogen receptors.…”

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confidence: 99%

Relationship between ploidy and steroid hormone receptors in primary invasive breast cancer

Horsfall¹,

Tilley²,

Orell³

et al. 1986

Br J Cancer

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“…[12][13][14] It seems that if Accepted for publication 24 July 1986 patients with oestrogen receptor positive tumours develop distant metastases they do so later than patients with oestrogen receptor negative tumours, but that the prognosis in the end is the same in both groups of patients.…”

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confidence: 99%

Prospective evaluation of prognostic value of morphometry in patients with primary breast cancer.

Linden¹,

Baak²,

Lindeman³

et al. 1987

J Clin Pathol

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SUMMARY In a prospective study the predictive value of a multivariate morphometric prognostic index was evaluated in 195 patients with primary breast cancer who had not been treated with any form of chemotherapy or hormonal treatment. The presence or absence of distant tumour recurrence combined with the scores of the prognostic index were compared with the survival curves predicted in a previous study. The value of the presence of lymph node metastases, number of positive nodes, tumour size, mitotic activity index, and oestrogen receptor status in prediction of prognosis were also investigated.In agreement with the results of the previous retrospective study, the prospective use of the index had the strongest predictive prognostic value, followed by the mitotic activity index. Statistical analysis showed that the actual prognoses of 43 of the 195 patients (22%) were more accurately determined by the prognostic index rather than by using the presence of the lymph node metastases as the classifying variable.The prognostic index is consistently reproducible by different technicians; it is a reliable method of predicting distant recurrence of tumour and hence the prognosis of patients with primary breast carcinoma. It provides more prognostic information than the presence of lymph node metastases alone, and the index should be incdrporated in routine pathology reports.

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The association of cytosol oestrogen and progesterone receptors with histological features of breast cancer and early recurrence of disease

Abstract: Summary Two hundred and eighty-eight primary breast tumours were examined for the presence or absence of oestrogen (RE,)

Cited by 59 publications

References 46 publications

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

Relationship between ploidy and steroid hormone receptors in primary invasive breast cancer

Prospective evaluation of prognostic value of morphometry in patients with primary breast cancer.

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