The association of depressive symptoms with survival in a Dutch cohort of patients with end-stage renal disease

Riezebos, Robert K.; Nauta, Klaas-Jan; Honig, Adriaan; Dekker, Friedo W.; Siegert, C. E. H.

doi:10.1093/ndt/gfp383

Cited by 71 publications

(54 citation statements)

References 27 publications

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“…172 Symptoms of depression are more frequent with reduction in kidney function and relate to poor outcome and mortality. [173][174][175] Cytokines are thought to be important mediators of brain immune connection and may play an important role in the pathogenesis of depression because of their effect on neurotransmitters and neurohormones. 173,176 In dialysis patients, symptoms of depression are associated with increased IL-6 levels, 177,178 and 8 weeks of fluoxetine treatment resulted in decreased serum IL-1b levels.…”

Section: Comorbidities and Lifestyle Comorbiditiesmentioning

confidence: 99%

Etiology of the Protein-Energy Wasting Syndrome in Chronic Kidney Disease: A Consensus Statement From the International Society of Renal Nutrition and Metabolism (ISRNM)

Carrero

Stenvinkel

Cuppari

et al. 2013

Journal of Renal Nutrition

703

569

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Protein-energy wasting (PEW), a term proposed by the International Society of Renal Nutrition and Metabolism (ISRNM), refers to the multiple nutritional and catabolic alterations that occur in chronic kidney disease (CKD) and associate with morbidity and mortality. To increase awareness, identify research needs, and provide the basis for future work to understand therapies and consequences of PEW, ISRNM provides this consensus statement of current knowledge on the etiology of PEW syndrome in CKD. Although insufficient food intake (true undernutrition) due to poor appetite and dietary restrictions contribute, other highly prevalent factors are required for the full syndrome to develop. These include uremia-induced alterations such as increased energy expenditure, persistent inflammation, acidosis, and multiple endocrine disorders that render a state of hypermetabolism leading to excess catabolism of muscle and fat. In addition, comorbid conditions associated with CKD, poor physical activity, frailty, and the dialysis procedure per se further contribute to PEW.

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Section: Comorbidities and Lifestyle Comorbiditiesmentioning

confidence: 99%

Etiology of the Protein-Energy Wasting Syndrome in Chronic Kidney Disease: A Consensus Statement From the International Society of Renal Nutrition and Metabolism (ISRNM)

Carrero

Stenvinkel

Cuppari

et al. 2013

Journal of Renal Nutrition

703

569

View full text Add to dashboard Cite

show abstract

“…Depression is a common problem in ESRD patients 31 and related to high mortality. 32,33 In peritoneal dialysis (PD) patients, depression was strongly related to inflammation, malnutrition, and multiple cardiovascular risk factors, suggesting that depression is an integral part of the MIA syndrome. 34 Indeed the state of depression associates with activation of proinflammatory cytokines, and patients on maintenance HD with symptoms of depression were more likely to have high levels of serum IL-6, higher prevalence of comorbidities, higher serum total cholesterol, and lower s-albumin levels.…”

Section: General Lifestyle Modifications That May Have Anti-inflammatmentioning

confidence: 99%

Therapeutics targeting persistent inflammation in chronic kidney disease

Machowska

Carrero

Lindholm

et al. 2016

Translational Research

104

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“…Furthermore, in addition to having greater mortality risk, depressed patients report poorer quality of life (2). Recent studies have also demonstrated an association between depressive affect, manifested by depressive symptoms, with higher mortality among patients with ESRD (3)(4)(5)(6)(7). Depressive symptoms and associated outcomes have been assessed by self-report using two questions within the Medical Outcomes Study Short Form 36 (SF-36) (4,5).…”

Section: Introductionmentioning

confidence: 99%

Depressive Affect and Hospitalization Risk in Incident Hemodialysis Patients

Lacson

Bruce

et al. 2014

Clinical Journal of the American Society of Nephrology

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Background and objectives Recent studies demonstrated an association between depressive affect and higher mortality risk in incident hemodialysis patients. This study sought to determine whether an association also exists with hospitalization risk.Design, setting, participants, & measurements All 8776 adult incident hemodialysis patients with Medical Outcomes Study Short Form 36 survey results treated in Fresenius Medical Care North America facilities in 2006 were followed for 1 year from the date of survey, and all hospitalization events lasting .24 hours were tracked. A depressive affect score was derived from responses to two Medical Outcomes Study Short Form 36 questions ("down in the dumps" and "downhearted and blue"). A high depressive affect score corresponded with an average response of "some of the time" or more frequent occurrence. Cox and Poisson models were constructed to determine associations of depressive affect scores with risk for time to first hospitalization and risk for hospitalization events, as well as total days spent in the hospital, respectively.Results Incident patients with high depressive affect score made up 41% of the cohort and had a median (interquartile range) hospitalization event rate of one (0, 3) and 4 (0, 15) total hospital days; the values for patients with low depressive affect scores were one (0, 2) event and 2 (0, 11) days, respectively. For high-scoring patients, the adjusted hazard ratio for first hospitalization was 1.12 (1.04, 1.20). When multiple hospital events were considered, the adjusted risk ratio was 1.13 (1.02, 1.25) and the corresponding risk ratio for total hospital days was 1.20 (1.07, 1.35). High depressive affect score was generally associated with lower physical and mental component scores, but these covariates were adjusted for in the models.Conclusions Depressive affect in incident hemodialysis patients was associated with higher risk of hospitalization and more hospital days. Future studies are needed to investigate the effect of therapeutic interventions to address depressive affect in this high-risk population.

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The association of depressive symptoms with survival in a Dutch cohort of patients with end-stage renal disease

Abstract: Patients with ESRD treated with dialysis show a high level of depressive symptoms that is independently associated with poor survival. Future research should address appropriate therapeutic regimens.

Cited by 71 publications

References 27 publications

Etiology of the Protein-Energy Wasting Syndrome in Chronic Kidney Disease: A Consensus Statement From the International Society of Renal Nutrition and Metabolism (ISRNM)

Etiology of the Protein-Energy Wasting Syndrome in Chronic Kidney Disease: A Consensus Statement From the International Society of Renal Nutrition and Metabolism (ISRNM)

Therapeutics targeting persistent inflammation in chronic kidney disease

Depressive Affect and Hospitalization Risk in Incident Hemodialysis Patients

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