The association of diabetes, subclinical hypothyroidism and carotid intima-media thickness: results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brazil)

Spilack, Aída de Melo; Goulart, Alessandra Carvalho; Almeida-Pititto, Bianca de; Janovsky, Carolina Castro Porto Silva; Lotufo, Paulo A.; Santos, Itamar S.; Benseñor, Isabela Judith Martins

doi:10.1016/j.clinsp.2022.100154

Cited by 1 publication

(1 citation statement)

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“…Studies have demonstrated that populations with elevated TSH levels significantly increase Intima-Media Thickness (IMT) in arterial blood vessels, including carotid IMT and aortic IMT. Lipid infiltration into arterial walls is considered the primary mechanism behind this elevated IMT ( 32 , 33 ). (3) Direct Stimulation of Macrophage Inflammatory Response: TSH can reportedly activate the MAPK (ERK1/2, P38, JNK) and I kappa B/P65 pathways in macrophages.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic potential of TSH to HDL cholesterol ratio in vulnerable carotid plaque identification

Lei,

Weng,

Wang

et al. 2024

Front. Cardiovasc. Med.

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ObjectiveThis study aimed to investigate the predictive value of the thyroid-stimulating hormone to high-density lipoprotein cholesterol ratio (THR) in identifying specific vulnerable carotid artery plaques.MethodsIn this retrospective analysis, we included 76 patients with carotid plaques who met the criteria for admission to Zhejiang Hospital from July 2019 to June 2021. High-resolution magnetic resonance imaging (HRMRI) and the MRI-PlaqueView vascular plaque imaging diagnostic system were utilized to analyze carotid artery images for the identification of specific plaque components, including the lipid core (LC), fibrous cap (FC), and intraplaque hemorrhage (IPH), and recording of the area percentage of LC and IPH, as well as the thickness of FC. Patients were categorized into stable plaque and vulnerable plaque groups based on diagnostic criteria for vulnerable plaques derived from imaging. Plaques were categorized based on meeting one of the following consensus criteria for vulnerability: lipid core area over 40% of total plaque area, fibrous cap thickness less than 65 um, or the presence of intraplaque hemorrhage. Plaques meeting the above criteria were designated as the LC-associated vulnerable plaque group, the IPH-associated group, and the FC-associated group. Multivariate logistic regression was employed to analyze the factors influencing carotid vulnerable plaques and specific vulnerable plaque components. Receiver operating characteristic (ROC) curves were used to assess the predictive value of serological indices for vulnerable carotid plaques.ResultsWe found that THR (OR = 1.976; 95% CI = 1.094–3.570; p = 0.024) and TSH (OR = 1.939, 95% CI = 1.122–3.350, p = 0.018) contributed to the formation of vulnerable carotid plaques. THR exhibited an area under the curve (AUC) of 0.704 (95% CI = 0.588–0.803) (p = 0.003), and the AUC for TSH was 0.681 (95% CI = 0.564–0.783) (p = 0.008). THR was identified as an independent predictor of LC-associated vulnerable plaques (OR = 2.117, 95% CI = 1.064–4.212, p = 0.033), yielding an AUC of 0.815. THR also demonstrated diagnostic efficacy for LC-associated vulnerable plaques.ConclusionThis study substantiated that THR and TSH have predictive value for identifying vulnerable carotid plaques, with THR proving to be a more effective diagnostic indicator than TSH. THR also exhibited predictive value and specificity in the context of LC-associated vulnerable plaques. These findings suggest that THR may be a promising clinical indicator, outperforming TSH in detecting specific vulnerable carotid plaques.

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Section: Discussionmentioning

confidence: 99%