The association of different types of cerebral infarction with post-stroke depression and cognitive impairment

Tu, Jun; Wang, Lingxiao; HongFeng, Wen; Xu, Yicheng; Wang, Pei-Fu

doi:10.1097/md.0000000000010919

Cited by 37 publications

(32 citation statements)

References 16 publications

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“…[1][2][3] Patients with PSD bear increased risk for cognitive impairment, stroke recurrence and death. [4][5][6] Hence, it is vital to identify and understand the pathogenesis of PSD early.…”

Section: Introductionmentioning

confidence: 99%

<p>Elevated Neutrophil-to-Lymphocyte Ratio Predicts Depression After Intracerebral Hemorrhage</p>

Xiao

Feng

et al. 2020

NDT

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Inflammation plays a critical role in the development of depression after intracerebral hemorrhage (ICH), while neutrophil-to-lymphocyte ratio (NLR) has been identified as a novel comprehensive inflammatory indicator in recent years. The aim of this study was to examine the association between NLR and depression after ICH. Patients and Methods: From January 2016 to December 2018, ICH patients were prospectively enrolled. NLR was measured at admission. Depression at 3 months after ICH was diagnosed according to the Hamilton Depression Scale (HAMD). Results: Of the 372 enrolled patients, 107 (28.8%) were diagnosed with depression at 3 months after ICH. Patients with depression had a higher NLR (6.15 vs 3.55, P < 0.001). Logistic regression analysis detected that after adjusting for major confounders, NLR remained independently associated with depression after ICH (OR = 2.25, 95% CI: 1.45-3.49, P < 0.001). Moreover, NLR acted as the optimal variable for prediction, with the optimal predictive threshold of 4.53 in ROC analysis. Conclusion: Elevated NLR is associated with depression at 3 months after ICH, suggesting that NLR may be a significant biomarker to predict depression after ICH.

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Section: Introductionmentioning

confidence: 99%

<p>Elevated Neutrophil-to-Lymphocyte Ratio Predicts Depression After Intracerebral Hemorrhage</p>

Xiao

Feng

et al. 2020

NDT

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“…PSD is strongly associated with further worsening of physical and cognitive recovery, functional outcome, and quality of life [20]. e impairment of physical and cognitive function is thought to be the factor most closely associated with PSD development and severity [25]. It has been shown that the physical and cognitive impairments could be reversed by treatment with TCM via targeting multiple pathways [26].…”

Section: Discussionmentioning

confidence: 99%

Jieyu Anshen Granule, a Chinese Herbal Formulation, Exerts Effects on Poststroke Depression in Rats

Ruan²,

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Jieyu Anshen granule (JY) is a traditional Chinese medicine formula for treating depression and anxiety. e aim of the study was to observe the effects of JY on poststroke depression (PSD) and investigate the underlying mechanism. PSD rat model was developed by middle cerebral artery occlusion following chronic unpredictable mild stress in conjunction with isolation rearing. We performed behavioral tests, Western blot, ELISA, and BrdU/NeuN staining. Treatment with JY showed significant antidepressant effect in open-field and sucrose preference tests, as well as significant improvement in beam-walking, cylinder, grip strength, and water maze tests. In addition, treatment with JY could restore the levels of neurotransmitters and decrease the levels of hormone and inflammation cytokines in serum and brain. Treatment with JY also showed significant regulation in the expression of neurotransmitter receptors and NF-κB/IκB-α signaling in the prefrontal cortex and hippocampus. Moreover, the numbers of newborn neurons in the hippocampus were increased by treatment with JY. Our results suggest that JY could ameliorate PSD and improve the neurological and cognitive functions. e antidepressive effect may be associated with the modulation of JY on monoamine system, neuroendocrine, neuroinflammation, and neurogenesis.

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“…We speculate that this phenomenon may have a cause. With the exception of migraine correlated with an increased risk of vascular disease, which is one of the risk factors for cognitive decline [ 20 , 32 , 33 ], repeated headache attacks could lead to cognitive dec-line [ 34 ]. Consequently, cognitive decline may begin much earlier for migraineurs than age-related cognitive decline.…”

Section: Discussionmentioning

confidence: 99%

“…suffering from major diseases that have been shown in previous studies to affect cognitive function, such as cerebral infarction [ 20 , 21 ], epilepsy [ 22 ], hypertension [ 23 ], head injury [ 24 ], intracranial tumor [ 25 ], and Parkinson's disease [ 26 ];…”

Section: Methodsmentioning

confidence: 99%

Early Age of Migraine Onset is Independently Related to Cognitive Decline and Symptoms of Depression Affect Quality of Life

Bao

Dong

et al. 2020

CNR

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Background: People with migraine experience cognitive decline more often than healthy controls, resulting in a significant functional impact. Early identifying influencing factors that contribute to cognitive decline in migraineurs is crucial for timely intervention. Although migraine may onset early in childhood and early onset migraine is related to significant disability, there is no research investigating the association between age of migraine onset and migraineurs’ cognitive decline. Therefore we aim to explore possible factors that correlate to cognitive function of migraineurs, especially focus on age of migraine onset. Method: 531 patients with migraine were included. Data on demographics and headache-related characteristics were collected and evaluated using face-to-face interviews and questionnaires. We used the Montreal Cognitive Assessment scale to assess cognitive function. In addition, we analyzed independent correlations between cognitive decline and the age of migraine onset in patients with migraine. And all patients completed the Headache Impact Test-6 to evaluate their quality of life. Results: Migraineurs with cognitive decline showed significant differences from those without in age (OR=1.26, P<0.0001), years of education (OR=0.89, P=0.0182), intensity of headache (OR=1.03, P=0.0217), age of onset (OR=0.92, P<0.0001) and anxiety scores (OR=1.09, P=0.0235). Furthermore there was no interaction in the age of onset between subgroups. Multivariate linear regression analyses of HIT-6 scores showed that the intensity of headache (β=0.18, P<0.0001) and depression scores (β=0.26, P=0.0009) had independent effects on decreased quality of life. Conclusion: Our findings suggest that younger age of migraine onset is independently related to migraineurs’ cognitive decline, and migraine accompanying anxiety symptoms significantly related to decreased quality of life in migraineurs.

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The association of different types of cerebral infarction with post-stroke depression and cognitive impairment

Cited by 37 publications

References 16 publications

<p>Elevated Neutrophil-to-Lymphocyte Ratio Predicts Depression After Intracerebral Hemorrhage</p>

<p>Elevated Neutrophil-to-Lymphocyte Ratio Predicts Depression After Intracerebral Hemorrhage</p>

Jieyu Anshen Granule, a Chinese Herbal Formulation, Exerts Effects on Poststroke Depression in Rats

Early Age of Migraine Onset is Independently Related to Cognitive Decline and Symptoms of Depression Affect Quality of Life

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