The Association of Elevated HDL Levels With Carotid Atherosclerosis in Middle-Aged Women With Untreated Essential Hypertension

Triantafyllidi, Helen; Pavlidis, George; Trivilou, Paraskevi; Ikonomidis, Ignatios; Tzortzis, Stavros; Xenogiannis, Iosif; Schoinas, Antonios; Lekakis, John

doi:10.1177/0003319715572679

Cited by 10 publications

(7 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study showed a statistically significant difference between extracranial atherosclerotic arterial stenosis and non-arterial stenosis regarding serum LDL cholesterol, and patients with extracranial arterial stenosis had the higher frequency of abnormal LDL cholesterol (high LDL-C). Also, in the present study, abnormal serum LDL cholesterol (high LDL-C) found to be an independent risk factor for extracranial atherosclerotic arterial stenosis, a finding which was in agreement with several previous studies [16,17].…”

Section: Discussionsupporting

confidence: 94%

Apolipoproteins A1 and B and their ratio in acute ischemic stroke patients with intracranial and extracranial arterial stenosis: an Egyptian study

Fahmy

Awady

Sharaf

et al. 2020

Egypt J Neurol Psychiatry Neurosurg

View full text Add to dashboard Cite

Background Apolipoprotein A1 and B and their ratio are considered a better biomarker for cardiovascular diseases than a lipid profile, but this previous finding is not proved to cerebrovascular ischemic diseases. The aim of this study is to assess the relation between apolipoprotien A1 and B and their ratio to intra- and extracranial carotid atherosclerosis in patients with ischemic acute stroke. Methods 90 Egyptian patients with acute ischemic stroke are included in the study, and they have been classified into 3 groups: group 1 includes 30 patients with intracranial stenosis, group 2 includes 30 patients with extracranial arterial stenosis, and group 3 includes 30 patients with non-arterial stenosis. Patients were subjected to clinical assessment, routine laboratory measures, and Color-Coded Duplex Sonography for extracranial and intracranial arteries. The measurement of serum levels of apolipoproteins A1 and B was done using enzyme-linked immuno-sorbent assay (ELISA). Results A statistically significant difference was found between patient groups as regards the frequency of abnormal serum LDL-cholesterol (p = 0.04), being elevated in patients with extracranial stenosis (p = 0.01). There was a significant difference between patients groups as regards the frequency of abnormal serum HDL-cholesterol (p = 0.02), being lower in patients with extracranial stenosis. High Apo B/A1 ratio was an independent risk factor for intracranial arterial stenosis (p = 0.045). An abnormal elevation of serum LDL cholesterol was an independent risk factor of extracranial arterial stenosis (p = 0.021). Conclusion Apo B/A1 ratio is an independent risk factor for intracranial arterial stenosis, while serum LDL cholesterol is an independent risk factor for extracranial arterial stenosis. Apo B/A1 ratio and serum LDL cholesterol are reliable serum biomarkers for cranial arterial stenosis in acute ischemic stroke patients.

show abstract

Section: Discussionsupporting

confidence: 94%

Apolipoproteins A1 and B and their ratio in acute ischemic stroke patients with intracranial and extracranial arterial stenosis: an Egyptian study

Fahmy

Awady

Sharaf

et al. 2020

Egypt J Neurol Psychiatry Neurosurg

View full text Add to dashboard Cite

show abstract

“…27 In a previous study, we found that elevated HDL-C > 70 mg/ dL may moderately predict the absence of carotid atherosclerosis in middle-aged women with untreated essential hypertension and consequently contribute to total CV risk estimation and treatment planning. 28 In the present study, we provided evidence that HDL-C ≥ 71 mg/dL protects endothelial function in older hypertensives with no other comorbidities. We chose to study a population F I G U R E 2 Correlation between PBR 5-9 (μm) and HDL-C levels (mg/dL) in the whole study population at risk since the majority of our patients had at least two risk factors, treated arterial hypertension under treatment and advanced age (90% of men aged ≥55 years and 61% of women aged ≥65 years).…”

Section: Discussionsupporting

confidence: 56%

HDL cholesterol levels and endothelial glycocalyx integrity in treated hypertensive patients

Triantafyllidi

Benas

Vlachos

et al. 2018

J of Clinical Hypertension

Self Cite

View full text Add to dashboard Cite

Endothelial dysfunction indicates target organ damage in hypertensive patients. The integrity of endothelial glycocalyx (EG) plays a vital role in vascular permeability, inflammation and elasticity, and finally to cardiovascular disease. The authors aimed to investigate the role of increased HDL cholesterol (HDL‐C) levels, which usually are considered protective against cardiovascular disease, in EG integrity in older hypertensive patients. The authors studied 120 treated hypertensive patients older than 50 years were divided regarding HDL‐C tertiles in group HDLH (HDL‐C ≥ 71 mg/dL, upper HDL‐C tertile) and group HDLL (HDL‐C < 71 mg/dL, two lower HDL‐C tertiles). Increased perfusion boundary region (PBR) of the sublingual arterial microvessels (ranging from 5 to 9 µm) using Sideview Darkfield imaging (Microscan, Glycocheck) was measured as a non‐invasive accurate index of reduced EG thickness. PBR 5‐9 was significantly decreased in group HDLH (P = 0.04). In the whole population, HDL‐C was inversely but moderately related to PBR 5‐9 (r = −0.22, P = 0.01). In a multiple linear regression analysis model, using age, BMI, smoking habit, HDL‐C, LDL‐C, and office SBP, as independent variables, the authors found that BMI (β = 0.25, P = 0.006) independently predicted PBR 5‐9 in the whole population. In older hypertensive patients, HDL‐C ranging between 71 and 101 mg/dL might moderately protect EG and subsequently endothelial function. Future studies in several groups of low‐ or high‐risk hypertensives are needed in order to evaluate the beneficial role of extremely elevated HDL‐C regarding cardiovascular risk evaluation as well as endothelial glycocalyx as a novel index of target organ damage in essential hypertension.

show abstract

“…Also, a growth in wall shear and oxidative stress, active and sustained inflammation, reduced the levels of nitric oxide in the endothelium; they all lead to the development of endothelial dysfunction. 14 , 15 …”

Section: Determinants Of Vascular Aging: From Morphology To Molecularmentioning

confidence: 99%

Vascular aging and subclinical atherosclerosis: why such a “never ending” and challenging story in cardiology?

Iurciuc¹,

Cîmpean²,

Mitu³

et al. 2017

CIA

View full text Add to dashboard Cite

The true onset of atherosclerosis remains one of the biggest challenges for cardiologists. Is atheroma plaque development considered the earliest step of vascular aging? If so, when it starts? Before or after birth? If it starts before birth or early during childhood, it seems that Thomas Sydenham was right: “A man is as old as his arteries.” Except disorganization of elastic fibers, less is known about the morphology of vascular aging and also about the molecular events influencing the age of arteries, arterial stiffness, and their role in the appearance of future complications. Cellular and molecular events responsible for the switch from physiologic to pathologic aging of human arteries are less known. Epigenetic, genetic, and environmental influences at the onset of early vascular aging (EVA) should specifically influence the process. This paper briefly reviews the controversial data regarding vascular aging with an emphasis on the less known facts about the morphology of EVA.

show abstract

The Association of Elevated HDL Levels With Carotid Atherosclerosis in Middle-Aged Women With Untreated Essential Hypertension

Cited by 10 publications

References 40 publications

Apolipoproteins A1 and B and their ratio in acute ischemic stroke patients with intracranial and extracranial arterial stenosis: an Egyptian study

Apolipoproteins A1 and B and their ratio in acute ischemic stroke patients with intracranial and extracranial arterial stenosis: an Egyptian study

HDL cholesterol levels and endothelial glycocalyx integrity in treated hypertensive patients

Vascular aging and subclinical atherosclerosis: why such a “never ending” and challenging story in cardiology?

Contact Info

Product

Resources

About

The Association of Elevated HDL Levels With Carotid Atherosclerosis in Middle-Aged Women With Untreated Essential Hypertension

Cited by 10 publications

References 40 publications

Apolipoproteins A1 and B and their ratio in acute ischemic stroke patients with intracranial and extracranial arterial stenosis: an Egyptian study

Apolipoproteins A1 and B and their ratio in acute ischemic stroke patients with intracranial and extracranial arterial stenosis: an Egyptian study

HDL cholesterol levels and endothelial glycocalyx integrity in treated hypertensive patients

Vascular aging and subclinical atherosclerosis: why such a &ldquo;never ending&rdquo; and challenging story in cardiology?

Contact Info

Product

Resources

About

Vascular aging and subclinical atherosclerosis: why such a “never ending” and challenging story in cardiology?