The association of fatty pancreas with subclinical atherosclerosis in nonalcoholic fatty liver disease

Öztürk, Kayhan; Doğan, Tolga; Celikkanat, Serhat; Özen, Alptuğ; Demirci, Hakan; Kurt, Ömer; Türker, Türker; Yılmaz, Yusuf; Uygun, Ahmet

doi:10.1097/meg.0000000000001059

Cited by 32 publications

(35 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7,8 Although several reports indicated the relationship between pancreatic steatosis measured by CT and atherosclerosis, most of them focused on arterial intima-media or intima thickness. 9,10 However, carotid plaque may provide more direct evidence of subclinical atherosclerosis than intimal thickness. In addition, predictive value of carotid plaque for cardiovascular adverse events may be higher than carotid intima-media thickness.…”

Section: Introductionmentioning

confidence: 99%

Computed Tomography-Estimated Pancreatic Steatosis is Associated with Carotid Plaque in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study from China

Sun¹,

Fan²,

Wang³

et al. 2021

DMSO

View full text Add to dashboard Cite

To explore potential effects of pancreatic fat content measured by computed tomography (CT) on carotid plaque in patients with type 2 diabetes mellitus (T2DM). Methods: T2DM patients who underwent an un-enhanced CT scan of the upper abdomen and ultrasound of the carotid artery were enrolled. The patients were divided into a non-plaque group and a plaque group (including hypoechoic plaque subgroup and non-hypoechoic plaque subgroup). The CT attenuation of pancreas and spleen were measured. Pancreas-to-spleen attenuation ratio (P/S) and the difference between pancreatic and splenic attenuation (P-S) were calculated. The cutoff values of P/S and P-S were obtained using receiver operating characteristic curves. Logistic regression models were used to evaluate association of P/S or P-S with carotid plaque or hypoechoic plaque. Results: 337 patients were enrolled, including 101 cases in the non-plaque group, 146 cases in the hypoechoic plaque subgroup, and 90 cases in the non-hypoechoic plaque subgroup. P/ S and P-S in hypoechoic plaque group were lower than those in non-plaque group, with a cut off value of P/S and P-S as 0.72 and −13.33, respectively.

show abstract

Section: Introductionmentioning

confidence: 99%

Computed Tomography-Estimated Pancreatic Steatosis is Associated with Carotid Plaque in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study from China

Sun¹,

Fan²,

Wang³

et al. 2021

DMSO

View full text Add to dashboard Cite

show abstract

“…Non-alcoholic fatty pancreas disease (NAFPD) has been related to CV disease [107]. Links between NAFPD and NAFLD, as well as EFT have also been reported [108][109][110]. It has been hypothesized that COPD may contribute to NAFPD development through systemic and local inflammation, excessive lipolysis and increased lipid synthesis, as well as intermittent hypoxia-induced pancreatic beta cell damage, thus representing potential mechanisms linking COPD with NAFPD [111].…”

Section: Peripancreatic Fat and Copdmentioning

confidence: 99%

“…However, as mentioned previously, there are also conflicting results [103,104]. Perirenal and NAFPD have been associated with CV risk, NAFLD, and EFT [106,[108][109][110], but there are no data on their association with COPD, despite the common pathogenetic mechanisms (e.g., oxidative stress, inflammation, and insulin resistance). Future research on this field is certainly needed.…”

Section: Current Knowledge and Future Perspectivesmentioning

confidence: 99%

Metabolic Syndrome and Abnormal Peri-Organ or Intra-Organ Fat (APIFat) Deposition in Chronic Obstructive Pulmonary Disease: An Overview

et al. 2020

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is a common disorder with an increasing prevalence, characterised by persistent respiratory symptoms and airflow limitation. Systemic inflammation is involved in the pathogenesis of COPD and can also predispose to metabolic disorders (e.g., metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD)). Such comorbidities can negatively affect COPD outcomes, cardiovascular risk, and quality of life. Apart from NAFLD, abnormal peri-organ or intra-organ fat (APIFat) could be considered as markers for cardiometabolic diseases and even for COPD. The present narrative review considers the associations of COPD with MetS, NAFLD, and other APIFat, including epicardial, perirenal, peripancreatic, and intramuscular adipose tissue. Further research is needed to define these relationships and identify any potential clinical implications.

show abstract

“…Pancreatic steatosis is manifestation of ectopic fat deposition, characterized by fat accumulation in the pancreas [5,24]. Pancreatic steatosis was related to carotid-femoral pulse wave velocity, which might predict carotid atherosclerosis in patients with non-alcoholic fatty liver disease [9]. Pancreatic steatosis was in proportion to aortic intima thickness [25] and systemic arterial calci cation [12].…”

Section: Relationship Between Pancreatic Steatosis and Carotid Plaquementioning

confidence: 99%

“…Although several reports indicated relationship between pancreatic steatosis measured by CT and atherosclerosis, most of them focused on arterial intima-media or intima thickness [9,10]. However, carotid plaque may provide more direct evidence of subclinical atherosclerosis than intimal thickness.…”

Section: Introductionmentioning

confidence: 99%

Computed Tomography-Estimated Pancreatic Steatosis is a Risk Factor for Carotid Plaque in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study

Sun

Fan

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Pancreatic steatosis correlates with the thickness of arterial intima. However, the correlation between pancreatic steatosis and carotid atherosclerosis plaque, which better predict the prognosis of cardiovascular disease, is unclear. We aimed to explore potential effects of pancreatic fat content measured by computer tomography (CT) on carotid plaque in patients with type 2 diabetes mellitus (T2DM).Methods Patients with T2DM who underwent CT scan of the upper abdomen and ultrasound of the carotid artery were consecutively enrolled. Based on ultrasound results, the patients were divided into non-plaque group and plaque group, and the latter was categorized into hypoechoic plaque subgroup and non-hypoechoic plaque subgroup. The CT attenuation of pancreas and spleen were measured. Pancreas-to-spleen attenuation ratio (P/S) and difference between pancreatic and splenic attenuation (P-S) were calculated. The cut-off values of P/S and P-S were obtained using receiver operating characteristic (ROC) curves. Logistic regression models were used to evaluate association of P/S or P-S with carotid plaque or hypoechoic plaque.Results A total of 337 patients with T2DM were enrolled, including 101 cases (30.0%) in the non-plaque group, 146 cases (43.3%) in the hypoechoic plaque subgroup, and 90 cases (26.7%) in the non-hypoechoic plaque subgroup. P/S and P-S in plaque group were lower than those in non-plaque group, with a cut-off value of P/S and P-S as 0.72 and -13.33, respectively. After adjusting for risk factors, P/S and P-S correlated with carotid plaque [for low P/S: OR (95% CI): 3.15 (1.47-6.73), P=0.0031; for low P-S: OR (95% CI): 2.84 (1.42-5.66), P=0.0031] as well as carotid hypoechoic plaque [for low P/S: OR (95% CI): 1.82 (1.07-3.08), P=0.0259; for low P-S: OR (95% CI): 1.82 (1.09-3.02), P=0.021].Conclusions T2DM patients with carotid plaque have higher pancreatic fat content than those without. Pancreatic steatosis correlates with carotid plaque and hypoechoic plaque in T2DM patients.

show abstract

The association of fatty pancreas with subclinical atherosclerosis in nonalcoholic fatty liver disease

Abstract: We have shown for the first time that fatty pancreas is a contributing factor for the development of atherosclerosis in patients with NAFLD. This study also confirms the strong association between NAFLD and fatty pancreas.

Cited by 32 publications

References 36 publications

Computed Tomography-Estimated Pancreatic Steatosis is Associated with Carotid Plaque in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study from China

Computed Tomography-Estimated Pancreatic Steatosis is Associated with Carotid Plaque in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study from China

Metabolic Syndrome and Abnormal Peri-Organ or Intra-Organ Fat (APIFat) Deposition in Chronic Obstructive Pulmonary Disease: An Overview

Computed Tomography-Estimated Pancreatic Steatosis is a Risk Factor for Carotid Plaque in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study

Contact Info

Product

Resources

About