The Association of Fgf23 and Inflammation in Heart Failure with Normal Kidney Function

Abstract

Keywords:Fibrosing growth factor23 C-reactive protein heart failure cardiomyopathy subclinical inflammation biomarkers A B S T R A C T Background: Fibroblast growth factor-23 produced by osteocytes regulates calcium and phosphate homeostasis which are cornerstones for bone integrity. Recently, FGF23 was also found to be directly related with both severity and prognosis of heart failure. However, the mechanism of FGF23 regulation in heart failure, particularly in patients with preserved renal function is poorly understood. Methods:In this retrospective single center trial we assessed the association of systemic inflammation (surrogated by CRP) and FGF23 regulation in 221 stable non-ischemic heart failure patients (age ≥ 18) with reduced ejection fraction and an estimated glomerular filtration rate of more than 60 ml/min/1.73m². Furthermore, we analyzed the prognostic ability of FGF23 and CRP in this population. Fasting ct-FGF23, highly sensitive CRP and a comprehensive panel of further biomarkers, as well as invasive hemodynamic measures from right heart catheterization, were used for univariate and multivariate regression analysis. Results:In bivariate correlation analysis ct-FGF23 was correlated with Cardiac output (r= -0.42); NTproBNP (r=0.34) and CRP (r=0.31); for all of those p < 0.001. Multivariate linear regression analysis revealed CRP and CO as independently associated with ct-FGF23 (total model fit; r²=0.32; p <0.001). In time to event analysis ct-FGF23 was the only independent parameter predicting transplant-free survival. Conclusion:Our data indicate an association of systemic inflammation and FGF23 in heart failure independent from renal function and supports the hypothesis that FGF23 may be directly involved in heart failure. 10. Manghat P, Fraser WD, Wierzbicki AS, Fogelman I, Goldsmith DJ et al. (2010) Fibroblast growth factor-23 is associated with C-reactive protein, serum phosphate and bone mineral density in chronic kidney disease.

Spektrale Kontrolle von elastischer Dynamik und Wärmetransport in periodischen Nanostrukturen

“…So könnte die Effizienz von vormals durch Wärmediffusion limitierte Anwendungen, wie thermoelektrische Geräte oder Brennkammern, erhöht werden [16][17][18]. Eine aktive Kontrolle der Wärmediffusion könnte es außerdem erlauben, thermische Leiterbahnen und Dioden zu konstruieren, die als Grundbausteine für thermische Logikschaltkreise dienen [19,20]. Auf diese Weise könnte die zur Zeit noch ungenutzte Abwärme von Computerchips nutzbar gemacht werden.…”

Bio-based crotonic acid production from wastewater

“…Such anti-solvents could be ethers, hexane and acetone which are best for precipitating SCL-PHAs, while most MCL-PHAs are soluble in these compounds. Solvent extraction results in a high purity of the polymer as well as its ability to remove endotoxins thereby enabling the polymer to be used in high grade medical applications [52]. Table 1-1 summarizes the performance of these solvents to extract PHAs from the biomass.…”