The association of frailty and outcomes of geriatric assessment with acute radiation-induced toxicity in patients with head and neck cancer

Vries, Julius de; Poelman, Anouk; Sidorenkov, Grigory; Festen, Suzanne; Bock, Geertruida H. de; Langendijk, Johannes A.; Laan, Bernard F. A. M. van der; Steenbakkers, R.J.H.M.; Halmos, György B.

doi:10.1016/j.oraloncology.2022.105933

Cited by 12 publications

(9 citation statements)

References 39 publications

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“…As a result, a multidisciplinary palliative care team with experience in managing these cases should preferably make all clinical decisions about the management of early OSCC [20]. For comprehensive patient treatment with positive results, a collaboration between palliative care experts, speech therapists, radiation oncologists, surgeons, dentists, and nurses is essential [21][22][23][24]. Studies have stated outcomes of radical radiotherapy and palliative care in patients with oral cancer [19].…”

Section: Discussionmentioning

confidence: 99%

Knowledge, Attitude, and Skills of Oral Health Care Professionals towards Cancer Treatment-induced Oral Mucositis.

Mohod,

Dadgal,

Sontakke

et al. 2024

Preprint

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Background and objectives: More than 90% of patients with head and neck malignancies develop cancer treatment-induced oral mucositis CT-IOM. It is commonly referred to stomatitis. It is a common, dose-limiting, and potentially life-threatening side effect of radiation or chemotherapy. The present study aimed to assess the knowledge, attitude, and skills of oral health care professionals working in different setups regarding the treatment and care of CT-IOM. Material and methods: This study used a questionnaire with 20 questions that was circulated to oral health care providers using Google Forms. The questionnaire collected data regarding the knowledge, attitude, and skills of oral health care professionals of CT-IOM using multiple answers questions and a Likert scale. The obtained information from the responders was statistically analyzed. Results:The study was conducted to compare the knowledge, attitude and skills among three groups of private practitioners, dental hospital and general hospitals. Among all the oral healthcare professionals, the responders working in the dental hospital setup are more aware than the private practitioners and the ones working in general hospitals of palliative care in CT-IOM Conclusion: The study concluded by stating that oral healthcare professionals need to be sensitized regarding palliative care and knowledge of CT-IOM.

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Section: Discussionmentioning

confidence: 99%

Knowledge, Attitude, and Skills of Oral Health Care Professionals towards Cancer Treatment-induced Oral Mucositis.

Mohod,

Dadgal,

Sontakke

et al. 2024

Preprint

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“…Type of treatment and neither frailty or geriatric assessment were predictive of treatment toxicity in their cohort. 54 In contrast, Morse et al 45 found that patients showing sarcopenia as a surrogate for frailty were more prone to developing treatment toxicities during chemoradiation. This finding is supported by Chou et al 55 and Karavolia et al, 56 who showed associations between increased vulnerability and OS and toxicity.…”

Section: Head and Neck Cancermentioning

confidence: 98%

“…Frailty is a relatively new term summarizing age-related physiological decline and functioning leading to increased vulnerability. De Vries and collaborators 54 analyzed 160 patients undergoing radiotherapy for head and neck cancer from 2014 to 2016. Type of treatment and neither frailty or geriatric assessment were predictive of treatment toxicity in their cohort.…”

Section: Head and Neck Cancermentioning

confidence: 99%

Geriatric Radiation Oncology: What We Know and What Can We Do Better?

Roeder¹,

Jensen²,

Lindel³

et al. 2023

CIA

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Elderly patients represent a growing subgroup of cancer patients for whom the role of radiation therapy is poorly defined. Older patients are still clearly underrepresented in clinical trials, resulting in very limited high-level evidence. Moreover, elderly patients are less likely to receive radiation therapy in similar clinical scenarios compared to younger patients. However, there is no clear evidence for a generally reduced radiation tolerance with increasing age. Modern radiation techniques have clearly reduced acute and late side effects, thus extending the boundaries of the possible regarding treatment intensity in elderly or frail patients. Hypofractionated regimens have further decreased the socioeconomic burden of radiation treatments by reducing the overall treatment time. The current review aims at summarizing the existing data for the use of radiation therapy or chemoradiation in elderly patients focusing on the main cancer types. It provides an overview of treatment tolerability and outcomes with current standard radiation therapy regimens, including possible predictive factors in the elderly population. Strategies for patient selection for standard or tailored radiation therapy approaches based on age, performance score or comorbidity, including the use of prediction tests or geriatric assessments, are discussed. Current and future possibilities for improvements of routine care and creation of high-level evidence in elderly patients receiving radiation therapy are highlighted.

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“…At least 80 % of patients receiving head and neck radiation suffer RIOM, and more than half experience severe (grade 3-4) oral mucositis. [1] RIOM manifests with erythema, erosion, ulceration and fibrosis of the oral mucosa, which causes severe pain, difficulty in eating, dry mouth and taste disturbance. [2] Although its serious impacts on the entire radiotherapy program and the quality of patient survival, [3] there is still no specific drug for the prevention and treatment of RIOM.…”

Section: Introductionmentioning

confidence: 99%

“…One of the frequent and dangerous side effects of radiotherapy for head and neck malignancies is radiation‐induced oral mucositis (RIOM), a damage to the oral mucosa produced by radioactive ionizing radiation. At least 80 % of patients receiving head and neck radiation suffer RIOM, and more than half experience severe (grade 3–4) oral mucositis [1] . RIOM manifests with erythema, erosion, ulceration and fibrosis of the oral mucosa, which causes severe pain, difficulty in eating, dry mouth and taste disturbance [2] .…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology and Molecular Docking Reveal the Mechanism of Corydalis saxicola Bunting Total Alkaloids in Treating Radiation‐Induced Oral Mucositis

Lai

Yong

Wei

et al. 2023

Chemistry & Biodiversity

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The study aims to explore the effect and mechanism of total alkaloids of Corydalis saxicola Bunting (CSBTA) in the treatment of radiation induced oral mucositis (RIOM) through network pharmacology and molecular docking. The components and corresponding targets of Corydalis saxicola Bunting were screened by literature review. RIOM related targets were obtained in GeneCards. Cytoscape software was used to construct the component‐target‐pathway network. Protein‐Protein Interaction (PPI) networks was constructed by String database. GO and KEGG enrichment analyses were performed by Metascape. AutoDock Vina 4.2 software was used for molecular docking. There were 26 components of CSBTA targeting 61 genes related to RIOM. Through Cytoscape and PPI analysis, 15 core target genes of CSBTA for treating RIOM were identified. GO functional analysis indicated that CSBTA might play a role through kinase binding and protein kinase activation. KEGG pathway analysis showed that the core targets of CSBTA were mainly focused on cancer and reactive oxygen species (ROS) pathway. The results of molecular docking showed that CSBTA had strong binding energy with target protein including SRC, AKT and EGFR. The study demonstrates that CSBTA may treat RIOM by affecting SRC, AKT and EGFR through ROS pathway.

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The association of frailty and outcomes of geriatric assessment with acute radiation-induced toxicity in patients with head and neck cancer

Cited by 12 publications

References 39 publications

Knowledge, Attitude, and Skills of Oral Health Care Professionals towards Cancer Treatment-induced Oral Mucositis.

Knowledge, Attitude, and Skills of Oral Health Care Professionals towards Cancer Treatment-induced Oral Mucositis.

Geriatric Radiation Oncology: What We Know and What Can We Do Better?

Network Pharmacology and Molecular Docking Reveal the Mechanism of Corydalis saxicola Bunting Total Alkaloids in Treating Radiation‐Induced Oral Mucositis

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