The Association of GSTM1 Deletion Polymorphism with Lung Cancer Risk in Chinese Population: Evidence from an Updated Meta-analysis

Abstract

Previous studies have reported the association of glutathione S-transferase M1 (GSTM1) deletion polymorphism with genetic susceptibility of lung cancer in Chinese population. However, the results remained controversial. The aim of this study was to clarify the association of GSTM1 deletion polymorphism with lung cancer risk in Chinese population. Systematic searches were performed through the search engines of Medline/Pubmed, Web of Science, EMBASE, CNKI and Wanfang Medical Online. The pooled effects were calculated by STATA 10.0 software package and Review Manager 5.0.24. Overall, we observed an association of GSTM1 deletion polymorphism with increased lung cancer risk in Chinese population (odds ratio (OR) = 1.46, 95% confidence interval (95%CI): 1.32–1.66 for null genotype vs. present genotype) based on 53 studies including 7,833 cases and 10,353 controls. We also observed an increased risk of GSTM1 null genotype for lung cancer in stratified analyses by source of control, smoking status and histological type. The findings suggest that GSTM1 deletion polymorphism may contribute to lung cancer risk in Chinese population. Further, well-designed studies with larger sample sizes are required to verify the results.

Lightning-fast genome variant detection with GROM

“…GROM predicted a deletion spanning the entire RHD gene, 1 of 2 genes responsible for Rh blood group antigens [ 30 ]. Decreased copy numbers or null genotype of GSTM1 have been associated with hepatotoxicity [ 31 ] and higher risk of many cancers including lung cancer [ 32 ], gastric cancer [ 33 ], and bladder cancer [ 34 ]. UGT2B17 copy number variation has been associated with changes in bone mineral density and risk of osteoporosis [ 35 ].…”

CYP2E1 and GSTM1 gene polymorphisms, environmental factors, and the susceptibility to lung cancer

“…Studies also showed that in smokers, there is higher risk of lung cancer for GSTM1 deficient type compared with GSTM1 functional type. This implies that either smoking and GSTM deficiency have a synergistic effect, or that both are risk factors of lung cancer; additionally, smoking subjects who carrying GSTM1 deficient would have an increased risk of lung cancer. This phenomenon could be explained by the fact that some procarcinogens (such as polycyclic aromatic amines (PHA) in cigarettes, 4,5 epoxidation benzo a pyrene (BaPo)) that are activated by phase I metabolic enzymes are substrates of GSTM1; GSTM1 plays an important role in the metabolic inactivation of these carinogens.…”

“…Studies also showed that in smokers, there is higher risk of lung cancer for GSTM1 deficient type compared with GSTM1 functional type. This implies that either smoking and GSTM deficiency have a synergistic effect, or that both are risk factors of lung cancer 25,26 ;…”

Associations of common copy number variants in glutathione S‐transferase mu 1 and D‐dopachrome tautomerase‐like protein genes with risk of schizophrenia in a Japanese population

“…Numerous studies of GSTM1 CNVs have been conducted following the discovery of the common null genotype as an early risk factor for some forms of cancer [Yang et al, ]. Furthermore, several studies have investigated relationships between the GSTM1 null genotype and schizophrenia.…”