2015
DOI: 10.2147/ott.s93745
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The association of GSTT1 deletion polymorphism with lung cancer risk among Chinese population: evidence based on a cumulative meta-analysis

Abstract: ObjectivePrevious studies investigating the relationship between glutathione S-transferase T1 (GSTT1) gene deletion polymorphism and lung cancer risk among Chinese population produced inconsistent results. To obtain a precise conclusion, we performed this meta-analysis to evaluate the association between GSTT1 deletion polymorphism and lung cancer risk among Chinese population.MethodsThe databases of Medline/PubMed, Embase, Web of Science, Wanfang Med Online, and Chinese National Knowledge Infrastructure were … Show more

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Cited by 10 publications
(16 citation statements)
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“…Ferlazzo et al (35) also found hypermethylation of cancer-related genes such as p16 and O 6 -methylguanine-DNA MGMT and suggested that these genes might be affected by MTHFR polymorphisms in oral squamous cancer. Wang et al (36) suggested A1298C AC+CC genotypes might be a risk factor for the development of breast cancer in Chinese population via meta-analysis. The A1298C CC genotype was found to be lower in prostate cancer tissues than control tissues (37)(38).…”
Section: Discussionmentioning
confidence: 99%
“…Ferlazzo et al (35) also found hypermethylation of cancer-related genes such as p16 and O 6 -methylguanine-DNA MGMT and suggested that these genes might be affected by MTHFR polymorphisms in oral squamous cancer. Wang et al (36) suggested A1298C AC+CC genotypes might be a risk factor for the development of breast cancer in Chinese population via meta-analysis. The A1298C CC genotype was found to be lower in prostate cancer tissues than control tissues (37)(38).…”
Section: Discussionmentioning
confidence: 99%
“…28 Moreover, based on meta-analyzes by Wang et al, there is some effect of the GSTT1 null variant on an increasing risk of lung cancer. 29 CRC -colorectal cancer; pT, pN, M -pathological TNM classification of the tumor; Tis -carcinoma in situ; T1-tumor invades the submucosa; T2 -tumor invades the muscularis propria; T3 -tumor invades through the muscularis propria into pericolorectal tissues; T4 -tumor penetrates to the surface of the visceral peritoneum; N0 -no regional lymph node metastasis; N1 -metastasis in 1-3 regional lymph nodes; N2 -metastasis in 4 or more regional lymph nodes; M0 -no distant metastasis; M1 -metastasis to distant organs.…”
Section: Discussionmentioning
confidence: 99%
“…GSTM1 and GSTT1 null genotype lost enzymatic functional activity, therefore, may increase the risk of lung cancer. To date, a series of previous meta-analysis have only focused on the association between single GSTM1 or GSTT1 gene polymorphism and lung cancer risk [1214, 63, 64]. However, the combined effect of GSTM1 and GSTT1 has not been reported previously.…”
Section: Discussionmentioning
confidence: 99%