The association of GSTT1 polymorphism with total antioxidant status of nasopharyngeal carcinoma patients

Farhat, Freba; Sari, Mayang; Chrestella, Jessy; Syari, Raudah Putri

doi:10.1063/5.0045622

Cited by 1 publication

(1 citation statement)

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“…Several populations in the world showed that GSTM1 gene null polymorphism and/or GSTT1 had the risk of type 2 DM (T2DM) compared with healthy control group [14], [15]. GSTT1 dan GSTM1 gene polymorphism and some diseases have been studied in Indonesia [16], [17], [18], [19], however, so far not research on T2DM. Therefore, this study was aimed to determine the role of GSTM1 and GSTT1 gene polymorphism in T2DM at Universitas Sumatera Utara Hospital, Medan, Indonesia.…”

Section: Introductionmentioning

confidence: 99%

Role of Glutathione S-transferase Mu 1 and Glutathione S-transferases Theta 1 Polymorphism in the Risk of Developing Type 2 Diabetes Mellitus at Universitas Sumatera Utara Hospital, Medan

Tala

Sari

2021

Open Access Maced J Med Sci

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BACKGROUND: Diabetes mellitus is associated with an increased production of reactive oxygen species (ROS) and a reduction in antioxidant defense. Glutathione S-transferases (GSTs) is group of multifunction antioxidant enzyme can be used as important biomarkers for DM.. GSTM1, T1 genes variant polymorphism result in decreased or loss of enzyme activity. AIM: The study aimed to evaluate the role of GSTM1 and GSTT1 gene polymorphism in the risk of developing T2DM. METHODS: GSTM1 and GSTT1 polymorphisms were genotyped in 87 T2DM patients and 87 healthy control group to analyze their association with T2DM susceptibility by using multiplex Polymerase Chain Reaction (PCR). PCR products were electrophoresed using agarose 2%. Odds ratio (OR) with 95% confidence interval (CI) and P value were calculated using SPSS software (version 21.0). RESULTS: The genotype distribution of GSTM1 and GSTT1 were not different between T2DM patients and healthy control group (p = 0.542, OR= 0.780, CI 95%=0.350-1.737 and p=0.879, OR=1.047, CI 95%=0.577-1.903). The genotype distribution of combination of GSTM1 and GSTT1 were also not not different between T2DM patients and healthy control group (p = 0.640, OR= 0.640, CI 95%=0.224-1.83 and p=0.551, OR=0.721, CI 95%=0.245-2.120. CONCLUSION: In summary, this study showed that GSTT1 null, GSTM1 null, the combination of GSTM1 null and GSTT1 null genotype or combination of GSTM1 null and GSTT1 positive (or contrary) did not have any risk of developing T2DM at Universitas Sumatera Utara Hospital, Medan.

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