The association of hearing loss with depressive symptoms and cognitive function among older people: Results from the Brazilian Longitudinal Study of Aging

Barbosa, Matheus; Oliveira, Déborah; Martinelli, Maria Cecília; Keinert, Ana Ágata Mezzomo; Lima‐Costa, Maria Fernanda; Suemoto, Cláudia Kimie; Ferri, Cleusa P.

doi:10.1002/gps.5904

Cited by 4 publications

(3 citation statements)

References 70 publications

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“…In summary, the primary observation of Papez circuit involvement is reasonable, as patients with presbycusis are more often accompanied by mood disorders, 41 , 42 cognitive deficits and difficulties in managing social relationships, which is consistent with previous neuroimaging findings. 43 , 44 …”

Section: Discussionsupporting

confidence: 88%

Neurovascular coupling dysfunction associated with cognitive impairment in presbycusis

Xing,

Feng,

Yao

et al. 2024

Brain Communications

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The neuropathological mechanism underlying presbycusis remains unclear. This study aimed to illustrate the mechanism of neurovascular coupling associated with cognitive impairment in patients with presbycusis. We assessed the coupling of cerebral blood perfusion with spontaneous neuronal activity by calculating the correlation coefficients between cerebral blood flow and blood oxygen level-dependent-derived quantitative maps (amplitude of low-frequency fluctuation, fractional amplitude of low-frequency fluctuation, regional homogeneity, degree centrality). Four neurovascular coupling metrics (cerebral blood flow-amplitude of low-frequency fluctuation, cerebral blood flow-fractional amplitude of low-frequency fluctuation, cerebral blood flow-regional homogeneity and cerebral blood flow-degree centrality) were compared at the global and regional levels between the presbycusis group and the healthy control group, and the intrinsic association between the altered neurovascular coupling metrics and the neuropsychological scale was further analysed in the presbycusis group. At the global level, neurovascular coupling was significantly lower in the presbycusis group than in the control group and partially related to cognitive level. At the regional level, neurovascular biomarkers were significantly elevated in three brain regions and significantly decreased in one brain region, all of which involved the Papez circuit. Regional neurovascular coupling provides more information than global neurovascular coupling, and neurovascular coupling dysfunction within the Papez circuit has been shown to reveal the causes of poor cognitive and emotional responses in age-related hearing loss patients.

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Section: Discussionsupporting

confidence: 88%

Neurovascular coupling dysfunction associated with cognitive impairment in presbycusis

Xing,

Feng,

Yao

et al. 2024

Brain Communications

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“…A clinical trial demonstrated that depression symptoms are controlled in SNL patients who provide interventions to treat ( 26 ). Moreover, recent studies have shown that audiological rehabilitation, including the use of sound amplification devices ( 31 ), and the availability of hearing aids and sound amplification devices ( 33 ), which probably would have slowed down the incidence of depression in SNL patients. Besides, SHL patients commonly suffer from varying degrees of social isolation, which may increase the development of depressive symptoms ( 34 – 36 ).…”

Section: Discussionmentioning

confidence: 99%

Bidirectional associations between sensorineural hearing loss and depression and anxiety: a meta-analysis

Zhang,

Li,

et al. 2024

Front. Public Health

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BackgroundRecently, the prevalence of sensorineural hearing loss (SNL) has been increasing, and several studies have suggested that depression, anxiety, and SNL may be associated with each other, however, individual findings still have discrepancies. To the best of our knowledge, no scholars have systematically elucidated the bidirectional associations between SNL, depression, and anxiety disorders from the perspective of meta-analysis. In this study, we aimed to systematically evaluate the bidirectional associations between SHL and depressive and anxiety symptoms, and to provide evidence-based medical evidence for reducing SNL, depression, and anxiety disorders.MethodsWe performed systematic review based on priori protocol that was registered with PROSPERO (No. CRD42022365963). Systematic search of PubMed, Embase, and Web of Science databases identified articles published as of June 1, 2023, on the relationship between SNL and depression and anxiety. Meta-analysis was performed to calculate the odds ratios (OR) and 95% confidence intervals (CIs) for the outcome metrics, and the results were combined to assess bivariate associations between the disorders with fixed or random effects. Sensitivity and subgroup analyzes were conducted to analyze sources of heterogeneity, and Egger’s and Begg’s tests combined with funnel plots were applied to assess publication bias.ResultsSummary analysis of the results of 20 studies covering 675,291 individuals showed that the bidirectional association between SNL and depression and anxiety disorders. The incidence (OR = 0.17, 95% CI: 0.09–0.28) and risk (OR = 1.43, 95% CI: 1.32–1.55) of depression and morbidity were higher in SNL patients than the general population. Elevated prevalence (OR = 0.46, 95% CI: 0.28–0.65) and risk (OR = 1.30, 95% CI: 1.11–1.48) of SNL were also observed in depressed patients. The prevalence of anxiety disorders among SNL patients was about 40% (OR = 0.40, 95% CI: 0.24%-0.57), which was associated with higher risk (OR = 1.83, 95% CI: 1.42–2.24) of development than the general population. Incidence of SNL in patients with anxiety disorders was approximately 31% (OR = 0.31, 95% CI: 0.29–0.33). Additionally, subgroup analyzes showed that the bidirectional associations between SNL, depression, and anxiety disorders was influenced by age, region, and mode of diagnosis of the disorders (SNL, depression, anxiety).ConclusionThere are bidirectional associations between SNL and depression and anxiety disorders, which was influenced by age and region and the method the disorders (SNL, depression, anxiety) were diagnosed.

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“…The bidirectional association demonstrated some degree of consistency with prior research, although these associations have only been validated independently and in a unidirectionally manner. The majority of these studies provided evidence that hearing difficulty predicts cognitive decline ( Amieva et al, 2015 ; de la Fuente et al, 2019 ; Armstrong et al, 2020 ; Slade et al, 2020 ; Barbosa et al, 2023 ). A systematic review of 35 studies revealed a strong correlation between hearing loss and an increased propensity for depression in older individuals ( Lawrence et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Bidirectional associations between hearing difficulty and cognitive function in Chinese adults: a longitudinal study

Li,

Hu,

Zhao

et al. 2023

Front. Aging Neurosci.

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BackgroundMiddle-aged and older adults frequently experience hearing loss and a decline in cognitive function. Although an association between hearing difficulty and cognitive function has been demonstrated, its temporal sequence remains unclear. Therefore, we investigated whether there are bidirectional relationships between hearing difficulty and cognitive function and explored the mediating role of depressive symptoms in this relationship.MethodWe used the cross-lagged panel model and the random-intercept cross-lagged panel model to look for any possible two-way link between self-reported hearing difficulty and cognitive function. To investigate depressive symptoms’ role in this association, a mediation analysis was conducted. The sample was made up of 4,363 adults aged 45 and above from the China Health and Retirement Longitudinal Study (CHARLS; 2011–2018; 44.83% were women; mean age was 56.16 years). One question was used to determine whether someone had a hearing impairment. The tests of cognitive function included episodic memory and intelligence. The Center for Epidemiologic Studies Depression Scale, which consists of 10 items, was used to measure depressive symptoms.ResultsA bidirectional association between hearing and cognition was observed, with cognition predominating (Wald χ2 (1) = 7.241, p < 0.01). At the between-person level, after controlling for potential confounders, worse hearing in 2011 predicted worse cognitive function in 2013 (β = −0.039, p < 0.01) and vice versa (β = −0.041, p < 0.01) at the between-person level. Additionally, there was no corresponding cross-lagged effect of cognitive function on hearing difficulty; rather, the more hearing difficulty, the greater the cognitive decline at the within-person level. According to the cross-lagged mediation model, depressive symptoms partially mediates the impact of cognitive function on subsequent hearing difficulty (indirect effect: −0.003, bootstrap 95% confidence interval: −0.005, −0.001, p < 0.05), but not the other way around.ConclusionThese results showed that within-person relationships between hearing impairment and cognitive function were unidirectional, while between-person relationships were reciprocal. Setting mental health first may be able to break the vicious cycle that relates hearing loss to cognitive decline. Comprehensive long-term care requires services that address depressive symptoms and cognitive decline to be integrated with the hearing management.

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The association of hearing loss with depressive symptoms and cognitive function among older people: Results from the Brazilian Longitudinal Study of Aging

Cited by 4 publications

References 70 publications

Neurovascular coupling dysfunction associated with cognitive impairment in presbycusis

Neurovascular coupling dysfunction associated with cognitive impairment in presbycusis

Bidirectional associations between sensorineural hearing loss and depression and anxiety: a meta-analysis

Bidirectional associations between hearing difficulty and cognitive function in Chinese adults: a longitudinal study

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