The association of Helicobacter pylori infection with serum lipid profiles: An evaluation based on a combination of meta-analysis and a propensity score-based observational approach

Shimamoto, Takeshi; Yamamichi, Nobutake; Gondo, Kenta; Takahashi, Yu; Takeuchi, Chihiro; Wada, Ryoichi; Mitsushima, Toru; Koike, Kazuhiko

doi:10.1371/journal.pone.0234433

Cited by 33 publications

(32 citation statements)

References 38 publications

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“…Among the metabolic parameters, serum HDL cholesterol level significantly decreased in subjects with Hp -seropositivity in both groups with and without NAFLD in this study. Several studies previously reported that Hp infection significantly affects serum lipid profiles, consistent with our results [ 36 , 37 ]. The secretion of inflammatory cytokines by chronic infection of gram-negative bacteria may be related to the change of lipid profiles [ 38 ].…”

Section: Discussionsupporting

confidence: 93%

The association between Helicobacter pylori with nonalcoholic fatty liver disease assessed by controlled attenuation parameter and other metabolic factors

et al. 2021

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Aim Existing studies have suggested an association between Helicobacter pylori (Hp) infection and nonalcoholic fatty liver disease (NAFLD). We investigated the relationship between Hp infection and NAFLD using controlled attenuation parameter (CAP) and other metabolic factors. Method We conducted a retrospective cohort study of apparently healthy individuals who underwent liver Fibroscan during health screening tests between January 2018 and December 2018. Diagnosis of Hp infection was based on a serum anti-Hp IgG antibody test and CAP values were used to diagnose NAFLD. Results Among the 1,784 subjects (mean age 55.3 years, 83.1% male), 708 (39.7%) subjects showed positive results of Hp serology. In the multivariate analysis, obesity (body mass index ≥25) (odds ratio [OR] 3.44, 95% confidence interval [CI] 2.75–4.29), triglyceride (OR 2.31, 95% CI 1.80–2.97), and the highest tertile of liver stiffness measurement (OR 2.08, 95% CI 1.59–2.71) were found to be associated with NAFLD, defined by CAP ≥248 dB/m, while Hp-seropositivity showed no association with NAFLD. Serum levels of HDL cholesterol significantly decreased in subjects with Hp-seropositivity compared to HP-seronegativity in both groups with and without NAFLD (P<0.001). Conclusion While Hp seropositivity was not associated with CAP-defined NAFLD, serum HDL cholesterol level were negatively associated with Hp-seropositivity in both groups with and without NAFLD. Further clinical and experimental studies are necessary to determine the association between Hp infection and NAFLD.

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Section: Discussionsupporting

confidence: 93%

The association between Helicobacter pylori with nonalcoholic fatty liver disease assessed by controlled attenuation parameter and other metabolic factors

et al. 2021

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“…However, some studies did not find correlations between H. pylori infection and some of these lipid variables (73,74). A recent meta-analysis of 27 previous studies concluded that most of the evidence tends towards an unfavorable lipid profile in H. pylori infected patients, although this is still casting doubt on the precise relationship with triglyceride levels (75). The causes of the altered lipid profile have not been elucidated, but impaired intestinal absorption and altered bile acid dynamics might be contributing to this condition (76).…”

Section: H Pylori Infection and Metabolic Diseasesmentioning

confidence: 99%

Gut Microbiota: The Missing Link Between Helicobacter pylori Infection and Metabolic Disorders?

et al. 2021

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Helicobacter pylori (H. pylori) is a gram-negative bacterium that infects approximately 4.4 billion individuals worldwide. Although the majority of infected individuals remain asymptomatic, this bacterium colonizes the gastric mucosa causing the development of various clinical conditions as peptic ulcers, chronic gastritis and gastric adenocarcinomas and mucosa-associated lymphoid tissue lymphomas, but complications are not limited to gastric ones. Extradigestive pathologies, including metabolic disturbances such as diabetes, obesity and nonalcoholic fatty liver disease, have also been associated with H. pylori infection. However, the underlying mechanisms connecting H. pylori with extragastric metabolic diseases needs to be clarified. Notably, the latest studies on the topic have confirmed that H. pylori infection modulates gut microbiota in humans. Damage in the gut bacterial community (dysbiosis) has been widely related to metabolic dysregulation by affecting adiposity, host energy balance, carbohydrate metabolism, and hormonal modulation, among others. Taking into account that Type 2 diabetic patients are more prone to be H. pylori positive, gut microbiota emerges as putative key factor responsible for this interaction. In this regard, the therapy of choice for H. pylori eradication, based on proton pump inhibitor combined with two or more antibiotics, also alters gut microbiota composition, but consequences on metabolic health of the patients has been scarcely explored. Recent studies from our group showed that, despite decreasing gut bacterial diversity, conventional H. pylori eradication therapy is related to positive changes in glucose and lipid profiles. The mechanistic insights explaining these effects should also be addressed in future research. This review will deal with the role of gut microbiota as the linking factor between H. pylori infection and metabolic diseases, and discussed the impact that gut bacterial modulation by H. pylori eradication treatment can also have in host’s metabolism. For this purpose, new evidence from the latest human studies published in more recent years will be analyzed.

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“…The existence of H. pylori infection was cross-sectionally associated with a high level of TG [ 11 ], and the present review found a slight but additional increase in TG levels following H. pylori eradication. H. pylori eradication increases the appetite [ 49 , 62 ] and improves nutrition [ 24 , 63 , 64 ], which can often promote obesity.…”

Section: Discussionmentioning

confidence: 51%

“…As the background theory, H. pylori infection is involved in the pathogenesis of atherosclerosis via activation of a local or systemic inflammatory host reaction and a subsequent induction of plaque progression and instability [ 2 ]. As abnormal lipid metabolisms contribute to the development of CVD [ 4 , 5 , 6 , 7 , 8 , 9 , 10 ], circulating lipids may be also involved in the relationship between H. pylori and CVD [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…The existence of H. pylori infection was shown to be associated with a low level of high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL-C), and total cholesterol (TC) or a high level of triglycerides (TG) in a recent meta-analysis of cross-sectional studies [ 11 ]. Nonetheless, the effect of H. pylori eradication on the lipid levels remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Helicobacter pylori Eradication on Lipid Levels: A Meta-Analysis

Watanabe

Hamasaki

Kotani

2021

JCM

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Introduction: Helicobacter pylori (H. pylori) infection is positively associated with cardiovascular diseases, but the involvement of lipids in this association remains unclear. The present study reviewed the changes in circulating lipid levels following H. pylori eradication. Methods: A PubMed database was searched until December 2020 to identify randomized control trials (RCTs) and non-RCTs investigating the effect of H. pylori eradication on the lipid levels in inverse variance-weighted, random-effects meta-analyses. Results: A total of 24 studies (four RCTs and 20 non-RCTs) with 5270 participants were identified. The post-eradication levels were increased for high-density lipoprotein cholesterol (HDL-C; mean difference (MD) 2.28 mg/dL, 95% confidence interval (CI) 1.90 to 2.66) and triglyceride (TG; MD 3.22 mg/dL, 95% CI 1.13 to 5.31) compared with the pre-eradication levels. H. pylori eradication resulted in little to no difference in the low-density lipoprotein-cholesterol levels (MD −2.33 mg/dL, 95% CI −4.92 to 0.26). In the analyses of RCTs only, the findings for elevated HDL-C levels, but not TG, were robust. Conclusions: H. pylori eradication increases the HDL-C levels. Further studies are needed to elucidate the effects of lipid changes following H. pylori eradication on cardiovascular diseases.

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The association of Helicobacter pylori infection with serum lipid profiles: An evaluation based on a combination of meta-analysis and a propensity score-based observational approach

Cited by 33 publications

References 38 publications

The association between Helicobacter pylori with nonalcoholic fatty liver disease assessed by controlled attenuation parameter and other metabolic factors

The association between Helicobacter pylori with nonalcoholic fatty liver disease assessed by controlled attenuation parameter and other metabolic factors

Gut Microbiota: The Missing Link Between Helicobacter pylori Infection and Metabolic Disorders?

The Effect of Helicobacter pylori Eradication on Lipid Levels: A Meta-Analysis

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