The Association of High Risk Human Papillomaviruses in Patients With Cervical Cancer: An Evidence Based Study on Patients With Squamous Cell Dysplasia or Carcinoma for Evaluation of 23 Human Papilloma Virus Genotypes

Piroozmand, Ahmad; Zadeh, Seyed Mostafa Mostafavi; Madani, Azita; Soleimani, Reza; Niakan, Mohammad; Avan, Amir; Manian, Mostafa; Moradi, Mohammad; Eftekhar, Zahra

doi:10.5812/jjm.32728

Cited by 20 publications

(21 citation statements)

References 22 publications

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“…In a meta-analysis study by Liu, the results showed that the association of TNF-308 G>A polymorphism with cervical cancer in the Asian population was significantly higher. [17][18][19][20][21][22][23][24][25] Our findings showed that TNF-308 G>A was associated with an increased risk of developing cervical cancer, supporting further investigations in a larger population and multi-center setting to reveal the prognostic value of the marker as a risk stratification biomarker in cervical cancer. 12 Another study showed that allele TNFa-308A induces an increase in TNF-a induction and its expression.…”

Section: Discussionsupporting

confidence: 60%

Association of TNF‐308 G>A polymorphism located in tumor necrosis factor a with the risk of developing cervical cancer and results of pap smear

Babapour

Mehramiz

Moghadam

et al. 2018

J of Cellular Biochemistry

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Tumor necrosis factor a (TNFa) is an inflammatory cytokine that plays a crucial role in the immune response and the progression of cervical lesions. There is a growing body of data evaluating the value of a genetic variant in the TNFa gene with the risk of developing cervical cancer. The aim of this study was to explore the association of a variant, TNF‐308 G>A, residing in the TNFa gene with cervical cancer. A total of 91 women with cervical cancer and 161 women as the control group were recruited. DNA was extracted, and Taqman®‐probes‐based assay was used for genotyping. Our results showed that the minor allele frequency was 0.3 in total population, and the frequency of minor allele A was more in the case group compared with the control. The regression models in different genetic models also revealed that the allele A is a potential risk factor for the development of cervical cancer. In particular, in the dominant model, patients with AG and AA genotypes had a higher risk of developing cervical cancer with odds ratio (OR) of 2.75 (95% confidence interval [CI]: 1.57‐4.83, <0.001) and OR of 7.27 (95%CI: 2.5‐20.8, <0.001), compared with the GG genotype. Moreover, a similar outcome was obtained for smear test results. Our study demonstrated that TNF‐308 G>A located on TNF‐a was associated with the risk of cervical cancer, supporting further studies in a larger population and multicenter setting to show the value of emerging markers as risk stratification biomarkers in cervical cancer.

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Section: Discussionsupporting

confidence: 60%

Association of TNF‐308 G>A polymorphism located in tumor necrosis factor a with the risk of developing cervical cancer and results of pap smear

Babapour

Mehramiz

Moghadam

et al. 2018

J of Cellular Biochemistry

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“…Likewise the presence of papilloma virus DNA has been demonstrated in inverted papillomas of dogs. As is the case in humans, it is suggested that the virus is the causative agent of these lesions [25]. Indeed, the histological findings clearly indicate viral replication taking place and consequently, causality is likely [26].…”

Section: Discussionmentioning

confidence: 91%

“…In addition, the authors found in two dogs viral DNA that appears to belong to two novel and distinct canine PVs. The sequences of these two viruses suggest that they may belong to the genus Lambda PVs and species COPV [25].…”

Section: Discussionmentioning

confidence: 99%

“…In humans, most of them occur in the nasal cavity, although cutaneous involvement has also been described [22]. Several papilloma viruses have been associated with the development of these lesions and neoplastic transformation often occurs when high-risk human papilloma viruses are involved [21,[23][24][25]. HPV 6/11 and HPV 16 were present in human inverted papillomas and research suggests that HPV 16 may be involved in malignant transformation [23,25].…”

Section: Discussionmentioning

confidence: 99%

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Investigation of a Putative Novel Papillomavirus that causes InvertedPapillomas in Horses

Ertelt¹,

Kershaw²,

Förster³

et al. 2017

Virol Mycol

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The Papillomaviridae family comprises a large number of viruses that can infect a broad range of hosts giving rise to benign lesions of the skin or mucosal membranes. Until today, seven viruses termed EcPV1-7 were identified in equine papillomas.Two trotter stallion siblings at the age of two were referred to the Equine Clinic of Free University of Berlin, because of erythema, alopecia and crusting. After a diagnosis of immune-mediated skin disease, the horses underwent long-term treatment with glucocorticoids and azathioprine. Two months later, both horses developed hundreds of small wart-like proliferations on the head, neck, chest and trunk. Six healthy horses, housed in the same stable, were used to assess the occurrence of the virus in healthy skin.Biopsies were obtained for histopathology and for amplification and cloning of the papillomavirus genome as well as for sequence analysis.Histopathology revealed well demarcated cup-shaped epidermal proliferations. Foci were covered by parakeratotic, or abnormally formed, keratin. In deeper layers, numerous enlarged cells with cytoplasmic eosinophilic inclusion-like structures and occasional intranuclear basophilic inclusion bodies were striking, existing beside cells with a peripheral cytoplasmic clearing (koilocytes). Histopathological findings were consistent with endophytic papilloma similar to the Le Net-type described in immunosuppressed dogs caused by a distinct canine papillomavirus. Furthermore, papillomavirus DNA was detected in tissue samples using a broad range PCR analysis. Preliminary phylogenetic analysis of a partial sequence from the L1 gene indicated a putative new papillomavirus that has not been described in horses so far. Biopsies of the control horses showed no abnormalities in histopathology and were tested negative for the putative novel papilloma virus DNA.

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“…Due to the delayed initial screening about 265,000 deaths from cervical cancer, especially in the developing countries, which representing a healthy threaten for women [1,2]. At present, a series of risk factors have been found to play important roles in the occurrence of cervical cancer, such as life style, hormonal contraceptives, immunosuppression or certain infections, especially human papilloma virus (HPV) [3][4][5][6][7]. However, the morbidity and mortality of cervical cancer are still increasing in the developing countries, and the patients tend to be younger [8].…”

Section: Introductionmentioning

confidence: 99%

MiR-221 represents an innovative bio-marker in cervical carcinoma detection

Cao¹,

Zheng²

2020

Preprint

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Background MiR-221 has been identified to play an important role in tumorigenesis and progression. In the present study, we aimed at to investigate the expression pattern of serum miR-221 and evaluate its diagnostic value in cervical cancer. Methods Quantitative real-time polymerase chain reaction (qRT-PCR) was used to measure the expression pattern of miR-221 in cervical cancer patients and healthy controls. The association of miR-221 with clinicopathological data was analyzed with χ2 test. Then receiver operating characteristic (ROC) curve was built to evaluate the diagnostic value of serum miR-221 by calculating the area under the ROC curve (AUC). Results The results indicated that the miR-221 expression level was statistically elevated in cervical cancer patients compared with healthy individuals. The increased miR-221 expression was significantly associated with lymph node metastasis (P = 0.026) and FIGO stage (P = 0.028). ROC curve suggested that serum miR-221 had a high diagnostic value in differentiating cervical cancer patients from healthy controls with AUC of 0.932 (95%CI: 0.903–0.960) corresponding with sensitivity of 77.6% and specificity of 94.8%. Conclusions Taken together, the expression level of miR-221 is increased in cervical carcinoma and it may serve as a promoting bio-marker in the diagnosis of cervical cancer patients.

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The Association of High Risk Human Papillomaviruses in Patients With Cervical Cancer: An Evidence Based Study on Patients With Squamous Cell Dysplasia or Carcinoma for Evaluation of 23 Human Papilloma Virus Genotypes

Cited by 20 publications

References 22 publications

Association of TNF‐308 G>A polymorphism located in tumor necrosis factor a with the risk of developing cervical cancer and results of pap smear

Association of TNF‐308 G>A polymorphism located in tumor necrosis factor a with the risk of developing cervical cancer and results of pap smear

Investigation of a Putative Novel Papillomavirus that causes InvertedPapillomas in Horses

MiR-221 represents an innovative bio-marker in cervical carcinoma detection

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