The association of HLA-DRB1 and HLA-DQB1 alleles with genetic susceptibility to multiple sclerosis in the Slovak population

Michalík, Jozef; Čierný, Daniel; Kantorová, Ema; Kantárová, Daniela; Javor, Juraj; Párnická, Zuzana; Kurča, Egon; Dobrota, Dušan; Lehotský, Ján

doi:10.1080/01616412.2015.1115212

Cited by 15 publications

(12 citation statements)

References 27 publications

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“…The main HLA associations in this study were HLA‐DRB1*15:01, HLA‐DQB1*06:02, DQB1*06:03 , and DQB1*02:01 . HLA‐DRB1*15:01 and DQB1*06:02 remain the most reported associations with MS in different ethnic groups . Other HLA alleles were also reported in certain ethnic groups, including DRB1*0301 , DQB1*0201, DRB1*0405, and DQB1 * 0301 .…”

Section: Discussionmentioning

confidence: 90%

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HLA class II polymorphism in Saudi patients with multiple sclerosis

Jumah

Kojan

Shehri

et al. 2017

HLA

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Several studies have investigated the association of different HLA antigens with multiple sclerosis (MS). However, only few studies have considered the association of high‐resolution HLA type and MS with none yet from Saudi Arabia. The aim of this study was to investigate the association of HLA class II alleles with MS in the Saudi population. We used next‐generation sequencing to investigate HLA association with MS. This study was conducted at King Abdulaziz Medical City in Riyadh, Saudi Arabia. We found that several HLA‐DRB1 and DQB1 alleles were associated with MS. These alleles included HLA‐DRB1*15:01 (odds ratio [OR]: 3.01; 95%, confidence interval [CI]: 1.68‐5.54; P = .0001), HLA‐DQB1*02:01 (OR: 1.76; 95% CI: 1.20‐2.58; P = .0022), HLA‐DQB1*06:02 (OR: 3.52; 95% CI: 1.87‐6.86; P < .0001), and HLA‐DQB1*06:03 (OR: 2.42; 95% CI: 1.16‐5.25; P = 0.01). Interestingly, HLA‐DRB1*15:01 was associated with increased risk of previous relapses. In addition, HLA‐DRB1*15:01 and HLA‐DQB1*06:02 were found to be associated with lower vitamin D levels. This study provides insights on the association of different HLA alleles with clinical characteristics and outcome of MS among Saudis. These insights can have future implications for the clinical management of MS based on the patient genetic profile.

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Section: Discussionmentioning

confidence: 90%

“…HLA-DRB1*15:01 and DQB1*06:02 remain the most reported associations with MS in different ethnic groups. [24][25][26][27] Other HLA alleles were also reported in certain ethnic groups, including DRB1*0301, DQB1*0201, DRB1*0405, and DQB1*0301. [28][29][30] There are few studies coming from the Arab world on HLA associations with MS.…”

Section: Discussionmentioning

confidence: 99%

HLA class II polymorphism in Saudi patients with multiple sclerosis

Jumah

Kojan

Shehri

et al. 2017

HLA

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“…HLA‐DQB1 alleles have diverse effects on susceptibility to autoimmune diseases. A stronger association between the DQB1 *06 alleles and disease susceptibility and a lower frequency of the DQB1 *03 alleles were observed in multiple sclerosis . Similar studies on HLA‐DQB1 polymorphisms showed a higher risk of type I diabetes among individuals with the DQB1 *0201/*0302 alleles, whereas the DQB1 *0301, DQB1 *0601,* DQB1 *0602, DQB1 *0603, and DQB1 *05 alleles protect against the development of type I diabetes .…”

Section: Discussionmentioning

confidence: 56%

Human leukocyte antigen‐DQB1 polymorphisms and haplotype patterns in Guillain‐Barré syndrome

Hayat

Jahan

Das

et al. 2019

Ann Clin Transl Neurol

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Objective The etiology of Guillain‐Barré syndrome (GBS) remains enigmatic, although genetic and environmental factors are speculated to be associated with this autoimmune condition. We investigated whether polymorphisms and the haplotype structures of the human leukocyte antigen (HLA)‐DQB1 gene relate to the autoimmune response to infection and affect the development of GBS. Methods HLA‐DQB1 polymorphic alleles (*0201, *030x, *0401, *050x, *060x) were determined for 151 Bangladeshi patients with GBS and 151 ethnically matched healthy controls using sequence‐specific polymerase chain reaction. Pairwise linkage disequilibrium (LD) and haplotype patterns were analyzed based on D ́statistics and the genotype package in R statistics, respectively. Association studies were conducted using Fisher's exact test and logistic regression analysis. The Bonferroni method was applied to correct for multiple comparisons, whereby the P‐value was multiplied with the number of comparisons and denoted as Pc (Pc, P corrected). Results No associations were observed between HLA‐DQB1 alleles and susceptibility to disease in the comparison between GBS patients and healthy subjects. Haplotype 9 (DQB1*0303‐*0601) tended to be less frequent among patients with GBS than healthy controls (P = 0.006, OR = 0.49, 95% CI = 0.30–0.82; Pc = 0.06). Haplotype 5 (DQB1*0501‐*0602) and the DQB1*0201 alleles were more frequent in the Campylobacter jejuni‐triggered axonal variant of GBS (P = 0.024, OR = 4.06, 95% CI = 1.25–13.18; Pc = 0.24) and demyelinating subtype (P = 0.027, OR = 2.68, 95% CI = 1.17–6.17; Pc = 0.35), though these associations were not significant after Bonferroni correction. Interpretation This study indicates that HLA‐DQB1 polymorphisms are not associated with susceptibility to GBS. In addition, these genetic markers did not influence the clinical features or serological subgroup in patients with C. jejuni‐triggered axonal variant of GBS.

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“…In addition, we also found that HLA-DRB1/DQB1 class II alleles DRB1*07, DRB1*13, DQB1*03, genotypes DRB1*13/*11, DQB1*05/*03 and haplotypes DRB1*13-DQB1*06 and DRB1*11-DQB1*03 are associated with the protection against MS development. We cannot exclude that the proposed protective effects of the DRB1*11-DQB1*03 and DRB1*13-DQB1*06 haplotypes in our cohort could be, at least partially, due to the linkagedisequilibrium with alleles in the HLA class I region which is primarily associated with MS [41].…”

Section: Hla Genes and Msmentioning

confidence: 88%

Genetic and Biochemical Factors Related to the Risk and Disability Progression in Multiple Sclerosis

Čierný¹,

Michalík²,

Kantorová³

et al. 2016

Trending Topics in Multiple Sclerosis

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Sclerosis multiplex (multiple sclerosis, MS) is a chronic autoimmune inflammatory disease of the central nervous system. The immune regulatory defects lead to the process of inflammation and neurodegenerationthat results in the deterioration of neurological functions. It is still unclear as to why MS is so devastating and rapidly progressive in one patient and less so in another. It is known that the etiopathogenesis of MS is very complex, and many factors can be involved in the risk and character of the disease and its progression. In this chapter, we discuss the general molecular and cellular mechanisms of action of genetic and biochemical factors that are related to immune system regulation and thus can be connected to the individually varying risk and disability progression of MS. We found that gene variants of the gene polymorphism rs6897932 in interleukin 7 receptor α chain gene rs10735810 in vitamin D receptor gene and HLA-DR and HLA-DQ genes as well as the serum level of vitamin D are associated with MS risk or disability progression in Central European Slovak population.

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The association of HLA-DRB1 and HLA-DQB1 alleles with genetic susceptibility to multiple sclerosis in the Slovak population

Abstract: This is the first study performed to analyse the association of HLA-DRB1/DQB1 with susceptibility to MS in Slovakia. The results of our study confirm that HLA class II alleles, genotypes and haplotypes are associated with MS risk.

Cited by 15 publications

References 27 publications

HLA class II polymorphism in Saudi patients with multiple sclerosis

HLA class II polymorphism in Saudi patients with multiple sclerosis

Human leukocyte antigen‐DQB1 polymorphisms and haplotype patterns in Guillain‐Barré syndrome

Genetic and Biochemical Factors Related to the Risk and Disability Progression in Multiple Sclerosis

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