The association of HLA-G polymorphism with oral and genital HPV infection in men

Suominen, Nelli T.; Jaakola, Anna Julia; Roger, Michel; Faucher, Marie-Claude; Syrjänen, Kari; Grénman, Seija; Syrjänen, Stina; Louvanto, Karolina

doi:10.1007/s10096-021-04362-8

Cited by 7 publications

(4 citation statements)

References 41 publications

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“…G*01:01:03 allele concordance lost statistical significance when the fathers' oral HR-HPV prevalence and children's oral HR-HPV prevalence at birth were explored separately; thus, it did not show an impact on one or the other's oral HR-HPV prevalence alone. Interestingly, in our recently published study, we found the presence of men's allele G*01:01:03 to associate with an increased risk for urethral HR-HPV infections [42].…”

Section: Discussionmentioning

confidence: 64%

“…Newborns' oral follow-up samples were collected at delivery and postpartum at day 3 and during 1-, 2-and 6-month follow-up visits. HPV genotyping was performed by the Multimetrix kit (Multimetrix, Progen Biotechnik GmbH, Heidelberg, Germany) identifying 24 different low-risk (LR) and high-risk (HR) HPV genotypes (LR genotypes : 6,11,42,43,44;and HR genotypes: 16,18,26,31,33,35,39,45,51,52,53,56,58,59,66,68,70,73,82) [34].…”

Section: Methodsmentioning

confidence: 99%

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HLA-G Alleles Impact the Perinatal Father–Child HPV Transmission

Suominen

Roger

Faucher

et al. 2023

CIMB

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The host factors that influence father-to-child human papillomavirus (HPV) transmission remain unknown. This study evaluated whether human leukocyte antigen (HLA)-G alleles are important in father-to-child HPV transmission during the perinatal period. Altogether, 134 father–newborn pairs from the Finnish Family HPV Study were included. Oral, semen and urethral samples from the fathers were collected before the delivery, and oral samples were collected from their offspring at delivery and postpartum on day 3 and during 1-, 2- and 6-month follow-up visits. HLA-G alleles were tested by direct sequencing. Unconditional logistic regression was used to determine the association of the father–child HLA-G allele and genotype concordance with the father–child HPV prevalence and concordance at birth and during follow-up. HLA-G allele G*01:01:03 concordance was associated with the father’s urethral and child’s oral high-risk (HR)-HPV concordance at birth (OR 17.00, 95% CI: 1.24–232.22). HLA-G allele G*01:04:01 concordance increased the father’s oral and child’s postpartum oral any- and HR-HPV concordance with an OR value of 7.50 (95% CI: 1.47–38.16) and OR value of 7.78 (95% CI: 1.38–43.85), respectively. There was no association between different HLA-G genotypes and HPV concordance among the father–child pairs at birth or postpartum. To conclude, the HLA-G allele concordance appears to impact the HPV transmission between the father and his offspring.

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Section: Discussionmentioning

confidence: 64%

Section: Methodsmentioning

confidence: 99%

HLA-G Alleles Impact the Perinatal Father–Child HPV Transmission

Suominen

Roger

Faucher

et al. 2023

CIMB

Self Cite

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“…Interestingly in our recently published study we found the presence of men's allele G*01:01:03 to associate with an increased risk for urethral HR-HPV infections [39].…”

Section: Discussionmentioning

confidence: 70%

“…Newborns oral follow-up samples were collected at delivery and postpartum at day 3 as 1-, 2-and 6-month follow-up visits. HPV genotyping was performed by the Multimetrix kit (Multimetrix, Progen Biotechnik GmbH, Heidelberg, Germany) identifying 24 different low risk (LR) and high risk (HR) HPV genotypes (LR-genotypes: 6, 11, 42,43,18,26,31,33,35,39,45,51,52,53,56,58,59,66,68,70,73,82) [26].…”

Section: Methodsmentioning

confidence: 99%

HLA-G alleles impact the perinatal father-child HPV transmission

Suominen

Roger

Faucher

et al. 2022

Preprint

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BackgroundThe host factors that influence the father-to-child human papillomavirus (HPV) transmission remain unknown. This study evaluated whether human leukocyte antigen (HLA)-G alleles are important in father-to-child HPV transmission during the perinatal period.MethodsAltogether, 134 father-newborn dyads from the Finnish Family HPV Study were included in the analyses. Oral, semen and urethral samples from the fathers were collected before the delivery, and oral samples from their offspring at delivery and postpartum at birth, day-3, at 1-, 2- and 6-month follow-up visits. HLA-G alleles were tested by direct sequencing. Unconditional logistic regression was used to determine the associations between the father-child HLA-G allele and genotype concordance and the father-child HPV prevalence and concordance at birth and during follow-up.ResultsHLA-G allele G*01:01:03 concordance was associated with father’s urethral and child’s oral high-risk (HR)-HPV concordance at birth (OR 17.00, 95%CI:1.24-232.22). Controversially at postpartum period G*01:01:03 discordance was associated with father’s urethral and child’s oral HR-HPV concordance (OR 6.67, 95%CI:1.08-40.97). HLA-G allele G*01:04:01 concordance increased the father’s oral and child’s postpartum oral any- and HR-HPV concordance, with OR 7.50 (95%CI:1.47-38.16) and OR 7.78 (95%CI:1.38-43.85), respectively. There was no association between different HLA-G genotypes and HPV concordance among the father-child dyads at birth or postpartum.ConclusionThe HLA-G allele concordance appears to impact the HPV transmission between the father and his offspring. This suggests that the father might have an important regulatory role in the natural history of his child’s oral HPV infection, which should be further explored.

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