The association of hypertriglyceridemic waist phenotype with hypertension: A cross‐sectional study in a Chinese middle aged‐old population

Xuan, Yan; Shen, Ying; Wang, Sujie; Ping, Guichen; Gu, Xi; Tang, Dou; Wang, Xun; Zhu, Fengshuo; Lu, Leiqun; Chen, Ling

doi:10.1111/jch.14424

Cited by 8 publications

(9 citation statements)

References 51 publications

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“…Our HTGW subjects had a significantly higher prevalence of hyperuricemia (67.6%) compared to those with NWNT phenotype (44.9%). This corroborates findings from similar studies [16,27,28]. The high prevalence of hyperuricemia in the HTGW phenotype agrees with the reported finding that elevated serum uric acid is associated with the metabolic syndrome, of which the HTGW phenotype is a surrogate of [46][47][48].…”

Section: Plos Global Public Healthsupporting

confidence: 92%

“…Our study also demonstrated greater aggregation of metabolic perturbations in the HTGW phenotype, which has been demonstrated by other studies [14][15][16]. The direct implication of this perturbations is a heightened risk of CVD, prospectively [29][30][31].…”

Section: Plos Global Public Healthsupporting

confidence: 87%

“…Hypertensives have been reported to be at increased of risk having HTGW phenotype [14][15][16]. In these hypertensives this phenotype is associated with a plethora of metabolic abnormalities, which increases the risk of incident CVD [17,18].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence, patterns and predictors of metabolic abnormalities in Nigerian hypertensives with hypertriglyceridemic waist phenotype: A cross sectional study

Amadi

Mbakwem²,

Duro³

et al. 2022

PLOS Glob Public Health

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Background Simultaneous presence of elevated waist circumference and hypertriglyceridemia (HTGW) is a simple and low-cost measure of visceral obesity, and it is associated with a plethora of cardio-metabolic abnormalities that can increase the risk of cardiovascular diseases and incident Type 2 diabetes mellitus. We decided to study the prevalence, patterns, and predictors of metabolic abnormalities in Nigerian hypertensives with the HTGW phenotype. Methods The medical records of 582 hypertensives with complete data of interest were retrieved and analyzed for the study. Their socio-demographic data, anthropometric data, and booking blood pressure values were retrieved. The results of their fasting plasma glucose, lipid profile, uric acid and serum creatinine were also retrieved for analysis. Results The mean age of the study population was 56.2 ±13.6, with 53.1% being males. The prevalence of smoking and use of alcohol was 4.3% and 26.5% respectively. The prevalence of the HTGW phenotype was 23.4% and were predominantly males (61%). Subjects with the HTGW phenotype were more obese assessed by waist circumference (WC) and body mass index (BMI). Mean serum total cholesterol, triglyceride, very low-density lipoprotein, uric acid, and creatinine were significantly higher in the HTGW phenotype (p = 0.003; <0.001; <0.001; 0.002 and <0.001 respectively). The prevalence of newly diagnosed Type 2 diabetes was 28.7%. There was also a preponderance of cardio-metabolic abnormalities (obesity, dyslipidaemia, hyperuricemia) in the HTGW phenotype. In both males and females, the HGTW phenotype was significantly associated with elevated Tc, TG, VLDL, hyperuricemia and atherogenic index of plasma. Conclusion The HTGW phenotype is common amongst Nigerian hypertensives, and it is associated with metabolic abnormalities.

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Section: Plos Global Public Healthsupporting

confidence: 92%

Section: Plos Global Public Healthsupporting

confidence: 87%

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Prevalence, patterns and predictors of metabolic abnormalities in Nigerian hypertensives with hypertriglyceridemic waist phenotype: A cross sectional study

Amadi

Mbakwem²,

Duro³

et al. 2022

PLOS Glob Public Health

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“…The hypertriglyceridemic-waist phenotype, defined as elevated TG and enlarged WC, was a simple marker of visceral adiposity [ 15 ]. Previous studies indicated that HTGW was associated with higher risk of diabetes, hypertension, and cardiovascular diseases [ 20 – 22 , 40 , 41 ]. A meta-analysis further indicated that HTGW was closely associated with an increased risk of diabetes in the general population [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Novel lipid indicators and the risk of type 2 diabetes mellitus among Chinese hypertensive patients: findings from the Guangzhou Heart Study

Deng

et al. 2022

Cardiovasc Diabetol

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Background Data are limited on whether several easily measured indices are independent predictors of type 2 diabetes mellitus (T2DM) in hypertensive patients. This study aimed to assess the association of hypertriglyceridemic-waist phenotype, triglyceride glucose (TyG) index, lipid accumulation product (LAP), and visceral adiposity index (VAI) with T2DM risk in hypertensive patients. Methods This cross-sectional study included 5321 hypertensive patients from the baseline survey of the Guangzhou Heart Study. Face-to-face questionnaire survey, physical examination, and fasting blood sample collection were completed for all subjects. Odds ratio (OR) with 95% confidence interval (95% CI) were calculated by using the logistic regression model. The potential nonlinear relationship was examined using restricted cubic spline regression. Results The prevalence of T2DM was 19.98% among hypertensive patients. After adjusting for confounders, participants with elevated triglyceride levels and enlarged waist circumference (HTGW) were associated with a 2.57-fold risk of T2DM (OR 2.57, 95% CI 2.05, 3.23). When comparing with subjects within the lowest quartile of the indices, those in the highest quartile of TyG, LAP, and VAI were associated with 5.35-fold (95% CI 4.33, 6.64), 2.65-fold (95% CI 2.11, 3.34), and 2.17-fold (95% CI 1.77, 2.67) risk of T2DM after adjusting for confounders. Every 1-unit increment of TyG, LAP, and VAI was associated with 81%, 38%, and 31% increased risk of T2DM, respectively. The nonlinear association was observed for TyG, LAP, and VAI (all PNon-linear < 0.001). Conclusions The results found that among hypertensive patients, HTGW and a higher level of TyG, LAP, and VAI were associated with an elevated risk of T2DM. The findings suggested that HTGW, TyG, LAP, and VAI may serve as simple and effective tools for T2DM risk assessment in the prevention and management of main chronic diseases.

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“…13 The HTGW phenotype has advantages in assessing individuals with higher risk of metabolic abnormalities compared with elevated TG or enlarged WC used alone. 14 Furthermore, several epidemiological studies showed the strong positive correlations of the HTGW phenotype with the risk of CVD, 15,16 prediabetes and diabetes, 17,18 hypertension, 19,20 and hyperuricemia. 21 Other studies reported the association of HTGW phenotype with an increasing risk of CKD in general middle-old adults 22,23 and in lean people (BMI < 24 kg/m 2 ).…”

Section: Introductionmentioning

confidence: 99%

The Association Between Hypertriglyceridemic-Waist Phenotype and Chronic Kidney Disease in Patients with Type 2 Diabetes: A Cross-Sectional METAL Study

Xuan¹,

Zhang²,

Wang³

et al. 2022

DMSO

Self Cite

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The aim of this study was measuring the association between the hypertriglyceridemic-waist (HTGW) phenotype and chronic kidney disease in a large type 2 diabetes population. Methods: A total of 4254 diabetic patients from the cross-sectional Environmental Pollutant Exposure and Metabolic Diseases in Shanghai (METAL) study were enrolled. The hypertriglyceridemic-waist (HTGW) phenotype was defined as the presence of an elevated waist circumference (WC) and elevated triglyceride (TG) concentration. Chronic kidney disease (CKD) was defined as an estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m 2 or urinary albumin creatinine ratio (uACR) more than 30 mg/g. Linear and multiple logistic regression models were used for measuring the association between HTGW phenotype and chronic kidney disease. Results: The prevalence of CKD was 29% and 35.8% in total participants and participants with HTGW phenotype, respectively. Subjects in the HTGW phenotype group were more likely to have CKD (OR 1.47, 95% CI: 1.11, 1.95) compared with subjects in the normal waist circumference and normal triglycerides (NTNW) group. HTGW phenotype was both associated with the increasing risk of decreased eGFR (OR 1.31, 95% CI: 1.02, 1.75) and elevated uACR (OR 1.57, 95% CI: 1.18, 2.11). Furthermore, the stratified analysis showed that the strongest positive association between HTGW phenotype and CKD presence was found in the subgroup of presence of hypertension. The associations were all fully adjusted for age, sex, BMI, current smoking, current drinking and other confounding factors. Conclusion:Our study suggested a positive association between the HTGW phenotype and CKD in Chinese type 2 diabetes patients. Further prospective studies are needed to confirm our findings and to investigate the underlying biological mechanisms.

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The association of hypertriglyceridemic waist phenotype with hypertension: A cross‐sectional study in a Chinese middle aged‐old population

Cited by 8 publications

References 51 publications

Prevalence, patterns and predictors of metabolic abnormalities in Nigerian hypertensives with hypertriglyceridemic waist phenotype: A cross sectional study

Prevalence, patterns and predictors of metabolic abnormalities in Nigerian hypertensives with hypertriglyceridemic waist phenotype: A cross sectional study

Novel lipid indicators and the risk of type 2 diabetes mellitus among Chinese hypertensive patients: findings from the Guangzhou Heart Study

The Association Between Hypertriglyceridemic-Waist Phenotype and Chronic Kidney Disease in Patients with Type 2 Diabetes: A Cross-Sectional METAL Study

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