The association of hyperuricemia and metabolic syndrome in Thai postmenopausal women

Techatraisak, Kitirat; Kongkaew, Teerakorn

doi:10.1080/13697137.2017.1369513

Cited by 11 publications

(7 citation statements)

References 30 publications

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“…Similar results were also reported by Techatraisak et al in post-menopausal Thai women. [ 22 ] Thus, the inconsistency among previous studies might be attributable to menopausal status. Several epidemiological studies have reported that SUA levels are higher in men than in women, [ 23 ] and the levels increased after menopause.…”

Section: Discussionmentioning

confidence: 99%

Association between serum uric acid levels and dyslipidemia in Chinese adults

Chen¹,

Yang²,

Chen³

et al. 2020

Medicine

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Section: Discussionmentioning

confidence: 99%

Association between serum uric acid levels and dyslipidemia in Chinese adults

Chen¹,

Yang²,

Chen³

et al. 2020

Medicine

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“…Experimental evidence suggests a potentially causal role for urate in the pathogenesis of hypertension and atherosclerosis [28]. It was reported that sUA concentrations are higher in postmenopausal than in premenopausal women [30]. As far as we know, in postmenopausal women who did not receive estrogen hormone therapy, sUA concentration tended to increase due to a shortage of the uricosuric effect of estrogen.…”

Section: Discussionmentioning

confidence: 99%

Association between Serum Urate and Risk of Hypertension in Menopausal Women with XDH Gene

Lee

et al. 2019

JCM

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Elevated serum urate (sUA) concentrations have been associated with an increased risk of hypertension. We aimed to examine the association of sUA concentration on the risk of hypertension in pre- and post-menopausal women and investigated the association between the polymorphism of the xanthine dehydrogenase gene and the risk of hypertension. Among 7294 women, 1415 premenopausal and 5879 postmenopausal women were recruited. Anthropometric parameters as risk factors of hypertension were identify by logistic regression models. In addition, we investigated an association between xanthine dehydrogenase gene and sUA and their combined associations on the risk of hypertension. Body mass index (BMI) and waist circumference (WC) were significantly increased in accordance to the increase of sUA levels (p < 0.001). Multivariate logistic regression analysis showed postmenopausal women with a high sUA and high BMI were 3.18 times more likely to have hypertension than in those with normal and lower sUA (Odds ratio: 3.18, 95% confidence interval: 2.54–3.96). Postmenopausal women with a high WC were 1.62 times more likely to have hypertension than in those with normal and lower sUA. Subjects with the AG genotype of rs206860 was found to be at lower risk of hypertension (odd ratio: 0.287, 95% confidence interval: 0.091–0.905, p = 0.033). This cross-sectional study indicated a high sUA is associated with a higher risk of hypertension in postmenopausal women. Further well-designed prospective studies in other populations are warranted to validate our results.

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“…Biochemical HA was defined by a free androgen index (FAI) of >6.8 [15]. MetS was defined by the presence of ≥3 risk factors: (1) WC >80 cm; (2) hypertension >130/85 mmHg; (3) fasting plasma glucose (FPG) >6.1 mmol/L; (4) triglycerides (TG) >1.7 mmol/L; and (5) high-density lipoprotein (HDL-C) <1.3 mmol/L [16].…”

Section: Methodsmentioning

confidence: 99%

Abdominal Obesity as a Predictive Factor of Nonalcoholic Fatty Liver Disease Assessed by Ultrasonography and Transient Elastography in Polycystic Ovary Syndrome and Healthy Women

Tantanavipas

Vallibhakara

Sobhonslidsuk

et al. 2019

BioMed Research International

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Polycystic ovary syndrome (PCOS) and nonalcoholic fatty liver (NAFLD) share similar clinical presentations including obesity, insulin resistance (IR), and metabolic abnormality. The predictive factors of NAFLD in women with PCOS and specifically in Asian women are not well established. Associated factors for NAFLD assessed by ultrasound (US) among a group of PCOS and healthy women were determined and diagnostic accuracy between US and transient elastography (TE) for NAFLD was compared and correlated. Sixty-three women with ages ranging from 20 to 40 years participated in the present cross-sectional study. Forty-two women with PCOS as diagnosed by the Rotterdam criteria and 21 healthy women were recruited into the study. Women with underlying hepatic diseases and history of alcohol consumption >20 g/day were excluded. Biochemical and hormonal testing, anthropometrics, liver US, and TE were assessed. Waist circumference (WC) greater than 80 cm was the only predictive factor for NAFLD as assessed by US in the whole group (adjusted odds ratio [aOR] 5.49, 95% confidence interval [CI]: 1.85–16.26, p <0.001). The value of the TE-based controlled attenuation parameter (CAP) was significantly correlated with stage of steatosis as assessed by US (correlation coefficient = 0.696, p <0.001). The diagnostic accuracies of dichotomized CAP ≥236 dB/m assessed for NAFLD using US as the gold standard were 84% and 78% sensitivity and specificity, respectively, with the area under the curve at 0.81 (p <0.001). Abdominal obesity, rather than the presence of PCOS, was shown to be the independently associated factor for NAFLD. WC could be used as the primary screening tool before performing complicated intervention for detection of steatosis. TE is an alternative noninvasive detection tool in women with PCOS for NAFLD and hepatic fibrosis identification.

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The association of hyperuricemia and metabolic syndrome in Thai postmenopausal women

Abstract: There was a significant association of hyperuricemia and MS in Thai postmenopausal women. These two co-morbidities were common after menopause. When hyperuricemia is diagnosed, MS should be screened, prevented or treated to decrease cardiovascular disease in the future.

Cited by 11 publications

References 30 publications

Association between serum uric acid levels and dyslipidemia in Chinese adults

Association between serum uric acid levels and dyslipidemia in Chinese adults

Association between Serum Urate and Risk of Hypertension in Menopausal Women with XDH Gene

Abdominal Obesity as a Predictive Factor of Nonalcoholic Fatty Liver Disease Assessed by Ultrasonography and Transient Elastography in Polycystic Ovary Syndrome and Healthy Women

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