The association of RAN and RANBP2 gene polymerphisms with Wilms tumor risk in Chinese children

Abstract

Wilms tumor is considered to be the most common renal malignancy among children. RAN, a member of RAS superfamily, and its binding partner RANBP2 are related to the progression of multiple tumors. Nevertheless, the effects of the RAN and RANBP2 gene polymorphisms on the tumorigenesis of Wilms tumor remain unclarified. In this study, three potentially functional polymorphisms (rs56109543 C>T, rs7132224 A>G, and rs14035 C>T) in the RAN and one (rs2462788 C>T) in the RANBP2 were chosen to investigate their association with Wilms tumor susceptibility. Odds ratios (ORs) and 95% confidence intervals (CIs) were applied to assess the association of the selected polymorphisms with Wilms tumor susceptibility. Results shown that RAN rs7132224 AG/GG genotypes significantly increased Wilms tumor risk when compared to AA genotype (adjusted OR=1.40, 95% CI=1.01-1.95, P=0.047). Carriers of 1-3 risk genotypes have a significantly higher Wilms tumor risk than those without risk genotype (adjusted OR=1.49, 95% CI=1.07-2.07, P=0.020). Moreover, stratified analysis indicated that RAN rs56109543 CT/TT genotypes, RAN rs7132224 AG/GG genotypes and RANBP2 rs2462788 CT/TT genotypes remarkably increased Wilms tumor susceptibility among the subgroups. Our results indicated that RAN and RANBP2 polymorphisms were associated with Wilms tumor susceptibility in Chinese children. The role of RAN/RANBP2 in cancers deserves more attention.

Investigation of the Relationship between CMYC Gene Polymorphisms and Glioma Susceptibility in Chinese Children

“…All subjects were treated at Guangzhou Women and Children's Medical Center and The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University. The inclusion and exclusion criteria for subjects were described in detail in our previous reports [27,28]. The case and control groups were matched for age and sex, and subjects were not close relatives.…”

The association of miR34b/c and TP53 gene polymorphisms with Wilms tumor risk in Chinese children

“…In the present study, we recruited 183 Wilms tumor patients and 603 cancer-free volunteers from Yuying Children's Hospital of Wenzhou Medical University and Guangzhou Women and Children's Medical Center [26,27]. The age, gender, and clinical stage of all participants are detailed in Supplementary Table S1.…”

Association ofRANandRANBP2Gene Polymorphisms With Glioma Susceptibility in Chinese Children

“…Knockdown of the RAN gene reduces expression of c‐Met and its downstream signaling target ERK1/2, significantly reducing the ability of A375 and G361 melanoma cells to migrate and invade [ 31 ]. RAN rs7132224 A>G was found to increase Wilms tumor risk [ 32 ]. RAN binding protein 2 ( RANBP2 ) forms the nuclear pore complex and regulates the transport of proteins and other molecules into or out of the nucleus.…”