The association of inflammatory markers and echocardiographic parameters in Behçet’s disease

Çalık, Ali Nazmi; Özcan, Kazım Serhan; Mesçi, Banu; Çınar, Tufan; Çanga, Yiğit; Güngör, Barış; Kavala, Mukaddes; Oğuz, Aytekin; Bolca, Osman; Kozan, Ömer

doi:10.1080/00015385.2018.1560071

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…The initial database search yielded 184 entries plus another 2 found on Google; following the screening and exclusion processes indicated in Fig. 1 , we identified 53 studies (52 full papers and one abstract) 6 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 examining the relationship between HC and BD (48 case–control and 5 cohort studies) that were included in our systematic review and meta-analysis ( Table 1 ). Of the 48 case–control studies, one did not report the mean ages of participants 22 and another did not report gender data (both full papers), 31 whereas a third (in abstract form only) did not report the mean ages and the gender data 40 : two missing data each for mean age of participants and for male/female ratio (4.1%) are unlikely to compromise the results of the sensitivity analysis; of the five cohort studies one did not report the mean age of participants.…”

Section: Resultsmentioning

confidence: 99%

Plasma Homocysteine in Behcet's Disease: A Systematic Review and Meta-Analysis

et al. 2022

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Aim To evaluate the relevance of plasma homocysteine (HC) in Behcet's disease (BD) and its clinical manifestations. Methods Systematic review of EMBASE and PubMed databases according to PRISMA guidelines from inception to July 2021; random-effects meta-analyses for continuous outcomes. Results The search strategy retrieved 48 case–control (2,669 BD and 2,245 control participants) and 5 cohort studies (708 BD participants). Plasma HC was higher in BD than in controls (p < 0.0001) with wide heterogeneity (I2 = 89.7%) that remained unchanged after sensitivity analysis according to year of article publication, age of BD participants, study size, study quality, method of HC determination, and male/female ratio >1.5; some pooled ethnicities explained a small part of the heterogeneity (I2 = 16.3%). Active BD participants had higher HC than inactive ones (p < 0.0001), with moderate heterogeneity (I2 = 49.2%) that disappeared after removal of an outlier study with very high disease activity. BD participants with any vascular involvement had higher HC than those without (p < 0.0001) with wide heterogeneity (I2 = 89.7%); subgroup analysis on venous thrombosis only changed neither effect size (p < 0.0001) nor heterogeneity (I2 = 72.7%). BD participants with ocular involvement had higher HC than those without (p < 0.0001) with moderate heterogeneity (I2 = 40.3%). Conclusion Although causality cannot be inferred, the consistency of the elevation of plasma HC in BD, particularly in patients with active disease, with vascular and ocular involvement suggests an intrinsic involvement of HC in these clinical manifestations.

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Section: Resultsmentioning

confidence: 99%

Plasma Homocysteine in Behcet's Disease: A Systematic Review and Meta-Analysis

et al. 2022

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“…18 High serum PTX3 levels have also been associated with increased cardiovascular complications in conditions such as Cushing's and Behçet's diseases and in hemodialysis patients. [19][20][21] In addition, there are studies on its potential superiority to CRP as a biomarker of cardiovascular disease due to its rapid response and ability to reflect vascular inflammation. 9,22,23 In a study conducted with childhood-onset systemic lupus erythematosus patients, it was found that serum PTX3 levels significantly increased in the presence of vasculitis, and it was reported that serum PTX3 levels could be useful in detecting subclinical vascular involvement.…”

Section: Discussionmentioning

confidence: 99%

“…Our results indicate that left ventricular diastolic functions are affected in the moderate/severe carditis group. In their study on individuals with Behçet’s disease, Çalık et al,[ 21 ] reported a correlation between serum PTX3 level and LAD and mitral E/A ratio. Similarly, in the present study, serum PTX3 level was positively correlated with left ventricular end-diastolic and LAD and mitral late diastolic pulse wave, and negatively correlated with E/A ratio in patients with acute episode of ARF.…”

Section: Discussionmentioning

confidence: 99%

Pentraxin 3 levels and correlation with disease severity in patients with acute rheumatic fever

et al. 2021

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Objectives: This study aims to investigate serum pentraxin 3 (PTX3) levels during acute episode of acute rheumatic fever (ARF) and their relationship with disease severity. Patients and methods: The prospective study was conducted between January 2015 and December 2018 and included 52 ARF patients (22 girls, 30 boys, mean age 10.7±2.1 years; range, 5 to 16 years) experiencing an acute episode and 22 healthy children (13 girls, 9 boys, mean age 10.3±3.8 years; range, 5 to 16 years). ARF patients were classified into three groups based on the clinical course: isolated arthritis (n=17), mild carditis (n=19), and moderate/severe carditis (n=16). Blood samples were collected from all patients before treatment and from the healthy children in the control group to measure PTX3 levels. PTX3 was measured using sandwich enzyme-linked immunosorbent assay method. Results: Plasma PTX3 levels were significantly higher in ARF group compared to the control group (4.7±5.2 and 1.2±1.7 ng/mL, p<0.001). Subgroup analysis of serum PTX3 levels in ARF patients with isolated arthritis, mild carditis, and moderate/severe carditis (3.2±3.1 ng/mL, 4.3±5 ng/mL, and 6.7±6.6 ng/mL, respectively) showed that serum PTX3 was significantly higher in the moderate/severe carditis group compared to the other groups (p<0.05). Analysis of echocardiographic data showed that serum PTX3 was positively correlated with left ventricular end-diastolic diameter, left atrial diameters, and mitral A velocity and negatively correlated with E/A ratio (p<0.05; r=0.231, 0.402, 0.562, -0.586, respectively). Conclusion: High PTX3 level during an acute episode of ARF may help predict the clinical course and the severity of accompanying carditis. However, prospective studies with larger sample sizes are needed.

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Association between blood Pentraxin‐3 concentrations and rheumatic diseases: A systematic review and meta‐analysis

Di Lorenzo,

Zoroddu,

Mangoni

et al. 2024

Eur J Clin Investigation

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BackgroundAmong the Pentraxins, the long Pentraxin‐3 (PTX‐3) is associated with several processes, particularly in the earliest phases of the innate humoral response. Increased blood PTX‐3 concentrations have been observed in a wide range of conditions, from infectious to cardiovascular disorders. Since its increase is more rapid than C‐reactive protein (CRP), PTX‐3 can be useful to detect and monitor early inflammation. To dissect its pathophysiological role in rheumatic diseases (RD), we conducted a systematic review and meta‐analysis comparing blood PTX‐3 concentrations in RD patients and healthy individuals and investigating possible associations with clinical, demographic, and study characteristics.MethodsWe performed a search of published evidence until April 2024 in PubMed, Web of Science and Scopus, which led to the selection of 60 relevant manuscripts from a total of 1072 records.ResultsOur synthesis revealed a statistically significant difference in PTX‐3 concentrations between RD patients and controls (standard mean difference, SMD = 1.02, 95% CI 0.77–1.26, p < .001), that correlated with CRP concentrations. The effect size was associated with geographical region of study conduction, RD type, with a reduction of the observed heterogeneity in patients with low LDL‐cholesterol and triglycerides concentrations.ConclusionsOur study has shown a significant increase in blood PTX‐3 concentrations in RD patients, which was associated with specific patient characteristics. Nevertheless, additional studies are needed to better define the utility of measuring PTX‐3 in the early phase of RD. Our study was conducted in compliance with the PRISMA 2020 statement (study protocol available at PROSPERO CRD42024516600).

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The association of inflammatory markers and echocardiographic parameters in Behçet’s disease

Cited by 3 publications

References 33 publications

Plasma Homocysteine in Behcet's Disease: A Systematic Review and Meta-Analysis

Plasma Homocysteine in Behcet's Disease: A Systematic Review and Meta-Analysis

Pentraxin 3 levels and correlation with disease severity in patients with acute rheumatic fever

Association between blood Pentraxin‐3 concentrations and rheumatic diseases: A systematic review and meta‐analysis

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