The association of innate immune response gene polymorphisms and puerperal group A streptococcal sepsis

Davis, Sarah M.; Clark, Erin; Nelson, Lesa; Silver, Robert M.

doi:10.1016/j.ajog.2010.01.006

Cited by 39 publications

(37 citation statements)

References 15 publications

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“…Previous association studies have revealed that rs187084 is associated with susceptibility to rheumatoid arthritis 22 , sepsis 23 and chronic periodontitis 24 . Although the rs352162 polymorphism was significantly related to the risk of MODS in trauma patients, the association of rs187084 and rs352162 appeared less strong in terms of their effect on cytokine production and sepsis morbidity rate.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in the toll-like receptor 9 gene associated with sepsis and multiple organ dysfunction after major blunt trauma

Chen¹,

Zeng²,

Gu³

et al. 2011

British Journal of Surgery

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Section: Discussionmentioning

confidence: 99%

Polymorphisms in the toll-like receptor 9 gene associated with sepsis and multiple organ dysfunction after major blunt trauma

Chen¹,

Zeng²,

Gu³

et al. 2011

British Journal of Surgery

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“…The severity of the response to GAS varies by patient [93-95] and the level of host cytokine production is correlated with the severity of disease [93, 96-100]. Of patients with previous postpartum infections, there were significant changes in allele frequencies compared to control patients for TLR9, hsp70 and IL-1β, suggesting that innate immune response gene polymorphisms are associated with susceptibility to severe GAS puerperal sepsis [101]. These studies have helped to clarify some of the host immune factors that influence infection risk, but further research is needed to clarify genetic predispositions of pregnant and postpartum women to GAS infection (or its complications).…”

Section: Introductionmentioning

confidence: 99%

Postpartum Group AStreptococcusSepsis and Maternal Immunology

Mason

Aronoff

2011

American J Rep Immunol

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Group A Streptococcus (GAS) is an historically important agent of puerperal infections and sepsis. The inception of hand-washing and improved hospital hygiene drastically reduced the incidence of puerperal sepsis, but recently the incidence and severity of postpartum GAS infections has been rising for uncertain reasons. Several epidemiological, host, and microbial factors contribute to the risk for GAS infection and mortality in postpartum women. These include the mode of delivery (vaginal vs. caesarean section), the location where labor and delivery occurred, exposure to GAS carriers, the altered immune status associated with pregnancy, the genetic background of the host, the virulence of the infecting GAS strain, and highly specialized immune responses associated with female reproductive tract tissues and organs. This review will discuss the complicated factors that contribute to the increased susceptibility to GAS after delivery and potential reasons for the recent increase observed in morbidity and mortality.

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“…A study on polymorphisms of innate immune response genes done in Utah found the frequency of the A allele of the HSP70 1267A > G polymorphism to be significantly higher in those with puerperal sepsis than matched controls. [19] This may suggest a higher frequency of polymorphisms in those with dysregulated inflammation as in sepsis.…”

Section: Discussionmentioning

confidence: 99%

Association between heat shock protein 70 gene polymorphisms and clinical outcomes in intensive care unit patients with sepsis

Ramakrishna

Pugazhendhi

Kabeerdoss

et al. 2014

Indian Journal of Critical Care Medicine

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Objective:The objective of the following study is to evaluate the associations between single nucleotide polymorphisms (SNPs) in the Heat Shock Protein 70 (HSP70) gene, gene expression of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) and medical intensive care unit (MICU) stay and organ failure in sepsis.Materials and Methods:MICU patients with sepsis were genotyped for rs1061581, rs2227956, rs1008438 and rs1043618 polymorphisms in HSP70 gene using polymerase chain reaction (PCR)-restriction fragment length polymorphism analysis or allele-specific PCR. Messenger ribonucleic acid (mRNA) expression of IL-6 and TNF-α were quantitated in peripheral blood lymphocytes. Outcomes were recorded.Results:108 patients (48 male) aged 40.7 ± 16.0 (mean ± standard deviation) years included H1N1 infection (36), scrub typhus (29) and urosepsis (12). Seventy-one (65.7%) had dysfunction of three or more organ systems, 66 patients (61.1%) were treated by mechanical ventilation, 21 (19.4%) needed dialysis. ICU stay was 9.3 ± 7.3 days. Mortality was 38.9%. One or more SNPs were noted in 101/108 (93.5%) and organ failure was noted in only 1/7 patients without a single SNP. The A allelotypes of rs1061581 and rs1008438 were associated with hematological dysfunction (P = 0.03 and 0.07) and longer ICU stay (P = 0.05 and 0.04), whereas IL-6 and TNF-α mRNA levels were associated with central nervous system dysfunction.Conclusions:HSP70 genotypes may determine some adverse outcomes in patients with sepsis.

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The association of innate immune response gene polymorphisms and puerperal group A streptococcal sepsis

Cited by 39 publications

References 15 publications

Polymorphisms in the toll-like receptor 9 gene associated with sepsis and multiple organ dysfunction after major blunt trauma

Polymorphisms in the toll-like receptor 9 gene associated with sepsis and multiple organ dysfunction after major blunt trauma

Postpartum Group AStreptococcusSepsis and Maternal Immunology

Association between heat shock protein 70 gene polymorphisms and clinical outcomes in intensive care unit patients with sepsis

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