The association of interferon‐gamma, interleukin‐4 and interleukin‐17 single‐nucleotide polymorphisms with susceptibility to tuberculosis

Mansouri, Fatemeh; Heydarzadeh, Rasoul; Yousefi, Saber

doi:10.1111/apm.12810

Cited by 15 publications

(11 citation statements)

References 31 publications

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“…Further analysis showed that MDS patients with synchronous TBI have higher risk strati cation, higher AML transformation rate, and shorter survival time, suggesting that these patients may have different genetic susceptibility bases. Previous studies have showed that some gene mutations and polymorphisms are associated with susceptibility to MDS, Among which, HLA-DRB1, GATA2 are also associated with TBI susceptibility [29,30]. Unfortunately, there have not enough data about gene polymorphism and mutation in our retrospective study to further analysis.…”

Section: Discussionmentioning

confidence: 83%

Clinical Characteristics and Outcomes of Tuberculosis Infection in Adult Patients with MDS

Ren

Chen

et al. 2020

Preprint

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Background and aim Despite the high incidence of tuberculosis infection (TBI) in patients with hematological diseases, there were few researches on TBI in MDS patients. We retrospectively analyzed the characteristics of MDS patients with TBI in our center to improve the clinical diagnosis and treatment of these patients.Methods Primary MDS patients diagnosed between 2014 and 2019 at the First Affiliated Hospital of Zhejiang University were retrospectively reviewed, TBI was diagnosed by positive culture(s) or acid fast bacilli on modified Ziehl-Neelsen staining on clinical samples as well as compatible symptoms and signs.Results Thirty-four of 1347 MDS patients were diagnosed with TBI, nine patients had blast＜5%, twelve patients were MDS with excess blast-1(MDS-EB1), and the rest 13 patients were MDS with excess blast-2 (MDS-EB2). Ten patients had lower risk (low and intermediate) and 24 patients had higher risk (high and very high) according to revised international scoring system (IPSS-R). Moreover, fifteen patients were classified into synchronous group (defined as TBI occurring within 3 months of MDS diagnosis), and the rest 19 patients were non-synchronous group (defined as TBI developed after MDS more than 3 months). Patients in synchronous group have higher rate of persistent fever (11/15 vs. 7/19, p=0.03), higher risk classification ( 14/15 vs. 8/19, P=0.002 ), and higher tendency to transform to acute myeloid leukemia (AML) (8/15 vs. 4/19, P=0.04 ) than those in non-synchronous group. The median time to AML was significantly shorter in synchronous group (7.68 months vs. 23.83 months, P<0.01). Most patients received regular anti-tuberculosis treatment (ATT)(33/34) and support care(22/34) for MDS, patients received support care were more prone to proceed to AML than those received active therapy such as decitabine (12/22 vs. 2/12, P=0.03). The median OS of all patients in synchronous group was just 14.17 months, while in non-synchronous group, it was 34.07 moths ( P = 0.01). However, treatments for MDS had no effect on OS(P=0.67).Conclusion TBI is not uncommon among patients with MDS, patients with synchronous TBI and MDS progress faster and have shorter OS, which may be associated with genetic susceptibility and lack of active therapy.

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Section: Discussionmentioning

confidence: 83%

Clinical Characteristics and Outcomes of Tuberculosis Infection in Adult Patients with MDS

Ren

Chen

et al. 2020

Preprint

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“…Bulat-Kardum et al [17] showed that the frequency of allele A (32.19%) is higher than the frequency of allele G (67.81%) in Chinese population. Mansouri et al [31] found that the IL-17 AG genotype and AA genotype in SNP rs2275913 were increased the risk of TB. These results are different with reports from some other populations.…”

Section: Discussionmentioning

confidence: 99%

“…Du et al [28] showed the development of TB could be influenced by other genetic factors. As well as the weak effect of genetic polymorphism, other genes work together in an immunity pathway with some environmental factors and thus affect the development of TB [30,31].…”

Section: Discussionmentioning

confidence: 99%

Genetic Polymorphisms of Il-17a in Association With the Risk of Pulmonary Tuberculosis in Iraqi Patients

Ameen

Abed

Utba

et al. 2018

Asian J Pharm Clin Res

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Objectives: Tuberculosis (TB) is an infectious disease that usually affects the lungs caused by Mycobacterium tuberculosis, TB is the second biggest killer, globally. The aim of this study was to examine the association between IL-17A rs2275913 SNP and pulmonary TB susceptibility in Iraqi population.Methods: From January 2017 to April 2017, 80 pulmonary TB patients were selected as the case group, another 40 healthy control were enrolled as the control group. The genotype frequencies of IL-17A rs2275913 was detected using amplification refractory mutation system.Results: The results of IL-17A serum level demonstrated that there were significant differences (p<0.05) between patients groups. The result showed that A allele have a higher frequency (55% vs. 50%) in TB patients than the control sample with OR value of 1.22 and EF value 0.1 and G have lower frequency (45% vs. 50%) in TB patients than control sample with OR value of 0.82 with PF value of 0.09, but this difference was not statistically significant (p>0.05).Conclusion: There were no significant associations between IL-17A rs2275913 polymorphism and risk of TB in Iraqi population.

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“…Повышение содержания IFNγ в цельной крови используется как тест, альтернативный туберкулиновой пробе. Известно, что наличие аллеля +874T в гене IFNG ассоциировано с повышенной экспрессией гена и, следовательно, с активацией продукции IFNγ [4,9]. Полиморфизм +874A/T гена IFNG (замена аденина на тимин) связан с восприим-чивостью к ТБ [4,6].…”

Section: таблица 3 содержание Ifnγ в супернатантах культурных суспенunclassified

Functional Polymorphism of the Pro-Inflammatory Cytokine Genes in Pulmonary Tuberculosis

Чурина¹,

Уразова²,

Новицкий³

et al. 2019

Med. immunol.

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In the present time, incidence of pulmonary tuberculosis (TB) becomes broader, due to spreading resistance ofMycobacterium tuberculosis(MBT) to anti-tuberculosis drugs and infection with highly virulent strains ofM. tuberculosis. The MBT antigens can cause dysfunction of the receptors and modulate the cytokine secreting function of immunocompetent cells. Polymorphic genes of pro-inflammatory cytokines involved in the mechanisms of defense responses of innate immunity, determine the degree of resistance to individual mycobacterial infection, as well as severity and duration of the disease in cases of clinical manifestations. The aim of the study was to investigate the connections between allelic polymorphisms of IL2, IFNG and TNFA genes and changes in secretion of the corresponding pro-inflammatory cytokines IL-2, IFNγ, and TNFα in vitro in patients with the newly diagnosed pulmonary tuberculosis (TB), depending on the clinical form of the disease.A total of 334 patients (220 men and 114 women) aged 23 to 50 years with newly diagnosed infiltrative and disseminated TB were enrolled into the study. The control group consisted of 183 healthy donors (130 men and 53 women) of corresponding age. The material of the research included DNA extracted from the whole blood and supernatants of culture suspensions of mononuclear leukocytes isolated from venous blood in healthy volunteers and patients with TB. The evaluation of cytokines secretion was performed by measuring their concentration in the blood mononuclear cell culture supernatants. using enzyme-linked immunosorbent assay (ELISA). To study polymorphic regions of cytokine genes, a polymerase chain reaction (PCR) was applied. Analysis of the obtained data was carried out by means of the program Statistica for Windows Version 6.0 (StatSoft Inc., USA).It was found that the imbalance of secretion of pro-inflammatory cytokines in TB patients was associated with the polymorphic variants of genes of these cytokines. It was found that the hypo-secretion of IL-2 is determined by the carriage of the G allele and genotype GG (T-330G) of the IL2 gene in both the control group and in patients with TB, regardless of the clinical form. In patients with DTB carriers of the homozygous genotype TT (T-330G) of the IL2gene, increased protein secretion was established. The maximum secretion of TNFб was recorded in patients with the AA genotype (G-308A) of the TNFA gene in the control group and in ITB patients; the minimum concentration of TNFα was associated with the carrier of the homozygous GG genotype (G-308A) of the TNFA gene in all the examined groups. In patients with ITB and DTB, an increase in IFNγ secretion by mononuclear blood leukocytes is not associated with the carrier of polymorphism +874A/T of the IFNG gene.Reduced secretion of IL-2 and TNFα in TB patients is associated with polymorphisms of their genes – (T-330G) of IL2 gene and (G-308A) of TNFA gene, respectively. The polymorphism (+874A/T) of the IFNG gene does not have a modulatory effect on the secretion of IFNγ in patients with TB, regardless of clinical form of the disease.

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The association of interferon‐gamma, interleukin‐4 and interleukin‐17 single‐nucleotide polymorphisms with susceptibility to tuberculosis

Cited by 15 publications

References 31 publications

Clinical Characteristics and Outcomes of Tuberculosis Infection in Adult Patients with MDS

Clinical Characteristics and Outcomes of Tuberculosis Infection in Adult Patients with MDS

Genetic Polymorphisms of Il-17a in Association With the Risk of Pulmonary Tuberculosis in Iraqi Patients

Functional Polymorphism of the Pro-Inflammatory Cytokine Genes in Pulmonary Tuberculosis

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