The association of living alone and social isolation with sarcopenia: A systematic review and meta-analysis

Yang, Jiaqing; Huang, Jing; Yang, Xinggang; Li, Shen; Wu, Xin; Ma, Xuelei

doi:10.1016/j.arr.2023.102043

Cited by 7 publications

(4 citation statements)

References 41 publications

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“…Sarcopenia has also been associated with social isolation, which can exacerbate its effects on health outcomes [55]. Social isolation, such as that experienced during the COVID-19 pandemic, has been linked to higher mortality rates and decreased quality of life among cancer patients [56].…”

Section: Resultsmentioning

confidence: 99%

Disparities in Clinical Outcomes and Risk Profiles Among Male and Female Chemotherapy Patients During COVID-19: An Observational Study

Lima,

Silva

et al. 2024

Preprint

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Objective To evaluate and describe clinical parameters and risk factors in patients undergoing chemotherapy during the COVID-19 pandemic, comparing men and women. Methods The sample comprised 106 cancer patients, mean age 54.12 (SD 16.18), both sexes (71 women and 35 men), with different types of cancer, all undergoing chemotherapy treatment. Assessments included anthropometric measurements, tetrapolar bioimpedance (phase angle), handgrip dynamometry, and the International Physical Activity Questionnaire (IPAQ). Results After analysis, 49% of the patients showed deviations from the ideal Body Mass Index (BMI) (13% below and 36% above ideal). The waist-hip ratio was adversely altered in 90.9% of patients, indicating a moderate to very high cardiovascular disease risk (27.3% moderate, 36.4% high, and 27.3% very high). Notably, no women exhibited a low risk, unlike men (31%) (p = 0.007). Reduced calf circumference was observed in 76% of patients. Regarding body composition, 62.9% of patients displayed significant changes in body fat percentage. The majority also exhibited inadequate handgrip strength levels (63.6%), with men being approximately four times more likely to have insufficient strength (p = 0.008, OR = 3.910). A phase angle below the recommended level was found in 94.8% of the sample. Physical activity assessment revealed a 100% sedentary lifestyle rate. Conclusion Patients undergoing chemotherapy during the COVID-19 pandemic had insufficient physical activity levels, inadequate handgrip muscle strength, and anthropometric indices and body composition with adverse changes, increasing cardiovascular risk and low phase angle reference values in the majority of the sample, with women displaying the most unfavorable profile. The research project was approved by the institutional review board, no. 5.069.269.

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Section: Resultsmentioning

confidence: 99%

Disparities in Clinical Outcomes and Risk Profiles Among Male and Female Chemotherapy Patients During COVID-19: An Observational Study

Lima,

Silva

et al. 2024

Preprint

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“…Another study, including 5289 participants from the CHARLS, demonstrated that social isolation was associated with an increased risk of sarcopenia [ 16 ]. Additionally, a recent review [ 12 ] concluded that living alone and social isolation are risk factors for sarcopenia. Our results strengthen the conclusion that active social participation is associated with a low risk of sarcopenia.…”

Section: Discussionmentioning

confidence: 99%

“…Current evidence suggests that positive support from the community/society can alleviate the negative effects of ACEs on mental health, physical health, and problem behaviours [ 8 – 11 ]. Contrastingly, living alone and social isolation (limited social participation) are associated with a risk of sarcopenia [ 12 ]. However, little is known regarding the modifying role of social participation in the relationship between ACEs and sarcopenia in older adults.…”

Section: Introductionmentioning

confidence: 99%

Adverse childhood experiences, sarcopenia, and social participation in older adults: a cohort study

Huang,

Li,

et al. 2024

BMC Public Health

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Objectives To examine the relationships between adverse childhood experiences (ACEs) and developing sarcopenia in older adults and the modifying effects of active social participation. Methods This prospective cohort study used survey data from the China Health and Retirement Longitudinal Study, including baseline surveys from 2011, follow-up data from 2013, follow-up data from 2015, and information on ACEs from the 2014 Life History Survey. Information concerning 10 ACEs, including five threat-related ACEs and five deprivation-related ACEs before 17 years of age was obtained by questionnaires through face-to-face interviews. Sarcopenia status was assessed according to the Asian Working Group for Sarcopenia 2019 algorithm, consisted of low muscle mass, and low muscle strength, or poor physical performance. The relationship between ACEs, social participation, and sarcopenia was evaluated using Cox proportional hazard regression models. Results The study population comprised 6859 older adults in main analyses. Having experienced ≥ 3 ACEs led to an increased 31% risk of developing sarcopenia (hazard ratio [HR]:1.31, 95% confidence interval [CI]:1.10–1.56). Participants having experienced ≥ 2 threat-related ACEs (HR:1.22, 95%CI:1.04–1.43) or deprivation-related ACEs (HR:1.22, 95%CI:1.02–1.46) had a 22% higher risk of developing sarcopenia. Active social participation significantly modified the association between ACEs (p < 0.05), especially threat-related ACEs (p < 0.05), and sarcopenia. Conclusions ACEs were associated with the development of sarcopenia; however, social participation had a modifying effect. These findings provide insights for early identification of vulnerable groups, advance intervention timing, and highlight the benefits of promoting active social participation among individuals with sarcopenia who have experienced ACEs.

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“…Social isolation-induced dysregulation of circadian rhythms, oxidative stress, and neuroendocrine dysregulation may lead to sarcopenia, resulting in the loss of muscle strength and decreased physical activity, ultimately contributing to the onset of frailty. 43 In addition, social isolation increases an individual’s susceptibility to life stressors, and increased glucocorticoid secretion due to maladaptive responses to stress has been shown to cause hippocampal damage that increases the risk of cognitive impairment. 44 According to the Cognitive Reserve Theory, 45 social networks can stimulate the formation of neuronal networks in the brain that resist structural damage to the brain associated with age or disease and delay cognitive decline.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Social Isolation and Cognitive Frailty Among Community-Dwelling Older Adults: The Mediating Role of Depressive Symptoms

Bai,

Chen,

Tian

et al. 2024

CIA

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The association of living alone and social isolation with sarcopenia: A systematic review and meta-analysis

Cited by 7 publications

References 41 publications

Disparities in Clinical Outcomes and Risk Profiles Among Male and Female Chemotherapy Patients During COVID-19: An Observational Study

Disparities in Clinical Outcomes and Risk Profiles Among Male and Female Chemotherapy Patients During COVID-19: An Observational Study

Adverse childhood experiences, sarcopenia, and social participation in older adults: a cohort study

The Relationship Between Social Isolation and Cognitive Frailty Among Community-Dwelling Older Adults: The Mediating Role of Depressive Symptoms

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