2010
DOI: 10.1159/000322057
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The Association of Metabolic Syndrome with Executive Dysfunction Independent of Subclinical Ischemic Brain Lesions in Japanese Adults

Abstract: Background/Aims: The aim of this study is to examine whether metabolic syndrome is directly associated with cognitive impairment independent of subclinical ischemic brain lesions. Methods: We examined 1,543 neurologically normal subjects (44–86 years of age). Metabolic syndrome, brain MRI, and cognitive functions including general cognition and executive function were assessed. Results: After adjusting for silent brain lesions and demographic risk factors, metabolic syndrome was an independent risk factor for … Show more

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Cited by 37 publications
(35 citation statements)
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References 78 publications
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“…Association of metabolic syndrome and with cognition has been equivocal, with studies showing negative, positive or neutral associations [10][11][12][13]21,23]. Gender and age may complicate the associations of MetS and cognition [11,12,[22][23][24][25][26][27].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Association of metabolic syndrome and with cognition has been equivocal, with studies showing negative, positive or neutral associations [10][11][12][13]21,23]. Gender and age may complicate the associations of MetS and cognition [11,12,[22][23][24][25][26][27].…”
Section: Discussionmentioning
confidence: 99%
“…Different domains of human cognition are thought to be variably affected by behavioral, psychological, lifestyle, environmental and other factors including metabolic syndrome (MetS) risk factors [2][3][4][5][6][7][8][9][10][11][12][13][14][15].…”
Section: Introductionmentioning
confidence: 99%
“…Multiple cognitive domains are affected, even after controlling for medical factors such as CVD and T2DM 28 , silent brain lesions 22 , education and socioeconomic status 2223 , depressive mood, coronary heart disease, and magnetic resonance imaging (MRI) findings. 23 MetS has been linked to deficits in memory, visuospatial abilities, executive functioning, processing speed, and overall intellectual functioning.…”
Section: Impact Of Mets On Cognition In Adultsmentioning
confidence: 99%
“…In postmenopausal women aged 50–65 years who were users of hormone replacement therapy, insulin resistance was associated with lower right and total hippocampal volume, and with worse overall cognitive performance and specific tests assessing verbal and nonverbal memory [10]. Metabolic syndrome was associated with poor cognitive performance in men aged 40–79 years [66] and with poor executive function in neurologically normal subjects aged 44–86 years of age, an effect that was independent of silent brain lesions [67]. Similarly, metabolic syndrome was associated with increased risk for cognitive impairment in a 4-year follow-up study of women who were cognitively intact at baseline [68].…”
Section: Insulin Resistancementioning
confidence: 99%