The association of metabolic syndrome and COVID-19 deterioration

Allard, Lucie; Bihan, H.; Bouillé, Jeanne Goupil de; Giroux-Leprieur, B.; Sutton, Angéla; Baudry, Camille; Josse, Constant; Didier, Morgane; Deutsch, David; Rezgani, I.; Bouchaud, Olivier; Cosson, E.

doi:10.1016/j.numecd.2021.08.036

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…The visceral fat is an important component of metabolic syndrome (MetS), another condition associated with poor prognosis in COVID-19. In previous case series, the prevalence of MetS in hospitalized COVID-19 patients was up to 81%, with a five-fold greater risk of disease deterioration and increased mortality risk as the MetS components count increased [31,32].…”

Section: Overweight Obesity Visceral Adiposity and Metabolic Syndromementioning

confidence: 86%

The Identikit of Patient at Risk for Severe COVID-19 and Death: The Dysregulation of Renin-Angiotensin System as the Common Theme

Sarzani

Allevi

Giulietti

et al. 2021

JCM

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Since the first months of the coronavirus disease 2019 (COVID-19) pandemic, several specific physiologic traits, such as male sex and older age, or health conditions, such as overweight/obesity, arterial hypertension, metabolic syndrome, and type 2 diabetes mellitus, have been found to be highly prevalent and associated with increased risk of adverse outcomes in hospitalized patients. All these cardiovascular morbidities are widespread in the population and often coexist, thus identifying a common patient phenotype, characterized by a hyper-activation of the “classic” renin-angiotensin system (RAS) and mediated by the binding of angiotensin II (Ang II) to the type 1-receptor. At the same time, the RAS imbalance was proved to be crucial in the genesis of lung injury after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, where angiotensin-converting-enzyme-2 (ACE2) is not only the receptor for SARS-CoV-2, but its down-regulation through internalization and shedding, caused by the virus binding, leads to a further dysregulation of RAS by reducing angiotensin 1-7 (Ang 1-7) production. This focused narrative review will discuss the main available evidence on the role played by cardiovascular and metabolic conditions in severe COVID-19, providing a possible pathophysiological link based on the disequilibrium between the two opposite arms of RAS.

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Section: Overweight Obesity Visceral Adiposity and Metabolic Syndromementioning

confidence: 86%

The Identikit of Patient at Risk for Severe COVID-19 and Death: The Dysregulation of Renin-Angiotensin System as the Common Theme

Sarzani

Allevi

Giulietti

et al. 2021

JCM

View full text Add to dashboard Cite

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“…Estimated worldwide prevalence of MetS is %25 [ 5 ], suggesting the clinical importance of identifying possible effects of MetS on COVID-19 disease course. Limited reports demonstrated increased risk of adverse and fatal outcomes in COVID-19 patients with MetS [ 6 , 7 ]. In this prospective study, we aimed to clarify the effects of MetS and its components on COVID-19 disease severity in moderate and severe cases.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Metabolic Syndrome Components and COVID-19 Disease Severity in Hospitalized Patients: A Pilot Study

Erman

Böyük

Sertbaş

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Background. Preliminary data suggest that patients with comorbidities are more susceptible to severe COVID-19 infection. However, data regarding the presence of metabolic syndrome (MetS) in patients with COVID-19 are scarce. Aim. In the present study, we aim to investigate the association between MetS components and disease severity in hospitalized COVID-19 patients. Methods. We conducted a prospective observational study of 90 hospitalized patients with COVID-19 pneumonia at a tertiary hospital. The study population consisted of inpatients who tested positive by the reverse transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2. Patients with critical COVID-19 disease on admission were excluded. Adult Treatment Panel III of the National Cholesterol Education Program (NCEP-ATP III) criteria were used to define MetS. Laboratory analysis and thorax CT were performed on admission. Results. 90 patients, 60 moderate and 30 severe COVID-19 patients, included in the study. The percentage of MetS cases was higher among severe COVID-19 patients ( p = 0.018 ). Of the MetS criteria fasting blood glucose ( p = 0.004 ), triglycerides ( p = 0.007 ) were significantly higher in patients with severe COVID-19 disease with no statistical significance found in waist circumference (WC) ( p = 0.348 ), systolic blood pressure ( p = 0.429 ), and HDL-C levels ( p = 0.263 ) between two groups. Body mass index (BMI) values were similar in both severe and moderate cases ( p = 0.854 ). In logistic regression analysis, serum triglycerides ( p = 0.024 ), HDL-C ( p = 0.006 ), and WC ( p = 0.004 ) were found as independent prognostic factor for severe COVID-19 infection. Conclusion. Severe COVID-19 patients have higher rates of MetS. Serum triglycerides, HDL-C, and WC have an impact on disease severity in COVID-19.

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Mapping the knowledge structure of research on insulin resistance and metabolic syndrome: a global perspective

Zyoud,

Shakhshir,

Abushanab

et al. 2024

transl med commun

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Background Insulin resistance is a major pathogenic factor that plays a crucial role in the development of metabolic syndrome and has been proposed as one of its underlying causes. Most diagnostic criteria for metabolic syndrome do not directly include insulin resistance. Furthermore, research on insulin resistance continues to provide information on the development and treatment of metabolic syndromes and related health conditions. Therefore, this bibliometric analysis aimed to investigate the current research status and identify possible future research hotspots in the area of metabolic syndrome and insulin resistance by analyzing Scopus-based studies. Methods To collect published data on metabolic syndrome and insulin resistance, this study used the Scopus database as its data source without a particular starting date but including records up to December 31, 2022. The gathered documents were then exported to VOSviewer v.1.6.18 to analyze and visualize country collaborations and identify research areas of high interest. Results The study presents an overview of 1932 records between 1988 and 2022, focusing on metabolic syndrome and insulin resistance. Of these records, 77.33% were original journal articles, while 13.30% were review articles. Additionally, 9.35% of the documents fall under other types of publication, including letters, notes, and editorials. The United States came out on top with 463 items, accounting for 23.96% of the contributions in this field, followed by Japan in second place with 119 items (6.16%). China (n = 113, 5.85%) and the United Kingdom (n = 113, 5.85%) ranked third. Most publications on metabolic syndrome and insulin resistance focus on key terms related to the pathogenesis of insulin resistance syndrome, the use of waist circumference as a crucial clinical indicator to evaluate the risk of metabolic syndrome, and the association between metabolic syndrome and oxidative stress and a pro-inflammatory state. Conclusions This study presents the first bibliometric analysis of publications focusing on metabolic syndrome and insulin resistance. The findings of this study offer a comprehensive global perspective on the research carried out on metabolic syndrome and insulin resistance and can be an invaluable source for future research.

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The association of metabolic syndrome and COVID-19 deterioration

Cited by 3 publications

References 28 publications

The Identikit of Patient at Risk for Severe COVID-19 and Death: The Dysregulation of Renin-Angiotensin System as the Common Theme

The Identikit of Patient at Risk for Severe COVID-19 and Death: The Dysregulation of Renin-Angiotensin System as the Common Theme

Relationship between Metabolic Syndrome Components and COVID-19 Disease Severity in Hospitalized Patients: A Pilot Study

Mapping the knowledge structure of research on insulin resistance and metabolic syndrome: a global perspective

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