The Association of Metabolic Syndrome and Its Components with Serum Prostate-Specific Antigen Levels in a Korean-Screened Population

Jeong, In Gab; Hwang, Seung Sik; Kim, Hoon Yub; Ahn, Hanjong; Kim, Choung‐Soo

doi:10.1158/1055-9965.epi-09-0760

Cited by 25 publications

(42 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among metabolic risk factors, waist circumference and fasting blood glucose levels were inversely correlated with serum PSA, whereas blood pressure was positively correlated. These associations remained significant after adjusting for age, BMI, and other metabolic risk factors (Jeong et al, 2010). According to Jeong et al (2010) the lack of association between metabolic syndrome and serum PSA may reflect the heterogeneous relationship between each metabolic risk factor and serum PSA.…”

Section: Prostate Specific Antigen and Metabolic Syndromementioning

confidence: 94%

“…These associations remained significant after adjusting for age, BMI, and other metabolic risk factors (Jeong et al, 2010). According to Jeong et al (2010) the lack of association between metabolic syndrome and serum PSA may reflect the heterogeneous relationship between each metabolic risk factor and serum PSA. In the contrary, Rundle et al (2009) found that waist circumference was positively associated with PSA level, even after controlling for BMI.…”

Section: Prostate Specific Antigen and Metabolic Syndromementioning

confidence: 94%

“…Metabolic syndrome is believed to affect the production of PSA through these metabolic activities that arise due to the presence of obesity and insulin resistance. Jeong et al (2010) investigated the association of metabolic syndrome and its metabolic components with serum PSA levels in a large screened population of 26,726 Asian men ages 40 years or older without a history of prostate cancer. They found that although mean PSA levels were lower in men with metabolic syndrome than in those without the condition, serum PSA was not associated with metabolic syndrome.…”

Section: Prostate Specific Antigen and Metabolic Syndromementioning

confidence: 99%

See 2 more Smart Citations

Prostate Cancer and Metabolic Syndrome: Is there a link?

McGrowder¹,

Jackson²,

Crawford³

2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Metabolic syndrome has become quite prevalent within our society. Over the past two decades, the prevalence of metabolic syndrome has sharply increased worldwide and it has become a major public health problem in several countries. It is associated with the global epidemic of obesity and diabetes mellitus and imposes numerous cardiovascular risks. Prostate cancer is the second most common cancer among men, surpassed only by non-melanoma skin cancer. A considerable body of evidence exists suggesting that some components of the metabolic syndrome have been associated with the risk of prostate cancer. These components include obesity, an abdominal fat distribution, and hyperinsulinemia. Androgen deprivation therapy (ADT) is the most widely used therapeutic modality in prostate cancer. It changed the body composition and lipid profile of men with prostate cancer. Androgen deficiency is associated with increased levels of total cholesterol, low-density lipoprotein (LDL)-cholesterol, increased production of proinflammatory factors, and increased thickness of the arterial wall and contributes to endothelial dysfunction. The aim of this review is to evaluate the association between metabolic syndrome and prostate cancer and to discuss the implications of androgen deficiency in men with cardiovascular risk factors. A comprehensive literature search was carried out with the use of PubMed from 1980 through 2011, and relevant articles pertinent to metabolic syndrome and prostate cancer are evaluated and discussed.

show abstract

Section: Prostate Specific Antigen and Metabolic Syndromementioning

confidence: 94%

Section: Prostate Specific Antigen and Metabolic Syndromementioning

confidence: 94%

Section: Prostate Specific Antigen and Metabolic Syndromementioning

confidence: 99%

See 1 more Smart Citation

Prostate Cancer and Metabolic Syndrome: Is there a link?

McGrowder¹,

Jackson²,

Crawford³

2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…However, most of the previous studies that examined the relationship of MS and PSA did not adjust prostate volume. [1][2][3][4][5][6] Interestingly, the PSA of men with MS was not higher than that without MS in those studies. mass (serum PSA 9 plasma volume) was used to adjust the plasma volume, and there were no significant differences of PSA mass between men with MS and without MS.…”

Section: Introductionmentioning

confidence: 73%

“…In contrast, some studies reported that serum PSA level is not influenced by MS. 5,6 A previous study using routine check-up data reported that the serum PSA level of MS patients was slightly lower than of non-MS men (1.119 ng/ mL vs 1.081 ng/mL, P = 0.001), but after adjustment of age and large plasma volume of men with MS, the difference disappeared (1.113 ng/mL vs 1.093 ng/mL, P = 0.10). 5 From this finding, the authors opined that slightly low PSA in men with MS results from hemodilution.…”

Section: Discussionmentioning

confidence: 96%

Prostate‐specific antigen lowering effect of metabolic syndrome is influenced by prostate volume

et al. 2016

View full text Add to dashboard Cite

Abbreviations & Acronyms ALT = alanine transaminase AST = aspartate aminotransferase BMI = body mass index BPH = benign prostatic hyperplasia BSA = body surface area Cr = serum creatinine DBP = diastolic blood pressure FBG = fasting blood glucose HDL = high-density lipoprotein LUTS = lower urinary tract symptom MS = metabolic syndrome PSA = prostate-specific antigen SBP = systolic blood pressure TRUS = transrectal ultrasonography Objectives: To investigate the influence of metabolic syndrome on prostate-specific antigen levels by considering prostate volume and plasma volume. Methods: We retrospectively analyzed 4111 men who underwent routine check-ups including prostate-specific antigen and transrectal ultrasonography. The definition of metabolic syndrome was based on the modified Adult Treatment Panel III criteria. Prostate-specific antigen mass density (prostate-specific antigen 9 plasma volume / prostate volume) was calculated for adjusting plasma volume and prostate volume. We compared prostate-specific antigen and prostate-specific antigen mass density levels of participants with metabolic syndrome (metabolic syndrome group, n = 1242) and without metabolic syndrome (non-prostate-specific antigen metabolic syndrome group, n = 2869). To evaluate the impact of metabolic syndrome on prostate-specific antigen, linear regression analysis for the natural logarithm of prostate-specific antigen was used. Results: Patients in the metabolic syndrome group had significantly older age (P < 0.001), larger prostate volume (P < 0.001), higher plasma volume (P < 0.001) and lower mean serum prostate-specific antigen (non-metabolic syndrome group vs metabolic syndrome group; 1.22 AE 0.91 vs 1.15 AE 0.76 ng/mL, P = 0.006). Prostate-specific antigen mass density in the metabolic syndrome group was still significantly lower than that in the metabolic syndrome group (0.124 AE 0.084 vs 0.115 AE 0.071 lg/mL, P = 0.001). After adjusting for age, prostate volume and plasma volume using linear regression model, the presence of metabolic syndrome was a significant independent factor for lower prostatespecific antigen (prostate-specific antigen decrease by 4.1%, P = 0.046). Conclusions: Prostate-specific antigen levels in patients with metabolic syndrome seem to be lower, and this finding might be affected by the prostate volume.

show abstract

Association between baseline serum glucose, triglycerides and total cholesterol, and prostate cancer risk categories

et al. 2016

View full text Add to dashboard Cite

Lifestyle‐related risk factors such as hyperglycemia and dyslipidemia have been associated with several cancers. However, studies exploring their link with prostate cancer (PCa) clinicopathological characteristics are sparse and inconclusive. Here, we investigated the associations between serum metabolic markers and PCa clinicopathological characteristics. The study comprised 14,294 men from the Swedish Apolipoprotein MOrtality RISk (AMORIS) cohort who were diagnosed with PCa between 1996 and 2011. Univariate and multivariable logistic regression were used to investigate the relation between glucose, triglycerides and total cholesterol and PCa risk categories, PSA, Gleason score, and T‐stage. Mean age at time of PCa diagnosis was 69 years. Men with glucose levels >6.9 mmol/L tend to have PSA<4 μg/L, while those with glucose levels of 5.6–6.9 mmol/L had a greater odds of PSA>20 μg/L compared to PSA 4.0–9.9 μg/L. Hypertriglyceridemia was also positively associated with PSA>20 μg/L. Hyperglycemic men had a greater odds of intermediate‐ and high‐grade PCa and advanced stage or metastatic PCa. Similarly, hypertriglyceridemia was positively associated with high‐grade PCa. There was also a trend toward an increased odds of intermediate risk localized PCa and advanced stage PCa among men with hypertriglyceridemia. Total cholesterol did not have any statistically significant association with any of the outcomes studied. Our findings suggest that high serum levels of glucose and triglycerides may influence PCa aggressiveness and severity. Further investigation on the role of markers of glucose and lipid metabolism in influencing PCa aggressiveness and severity is needed as this may help define important targets for intervention.

show abstract

The Association of Metabolic Syndrome and Its Components with Serum Prostate-Specific Antigen Levels in a Korean-Screened Population

Cited by 25 publications

References 51 publications

Prostate Cancer and Metabolic Syndrome: Is there a link?

Prostate Cancer and Metabolic Syndrome: Is there a link?

Prostate‐specific antigen lowering effect of metabolic syndrome is influenced by prostate volume

Association between baseline serum glucose, triglycerides and total cholesterol, and prostate cancer risk categories

Contact Info

Product

Resources

About