The association of metabolic syndrome, insulin resistance and non-alcoholic fatty liver disease in overweight/obese children

El-Koofy, Nehal; Anwar, Ghada M.; El-Raziky, Mona; El-Hennawy, Ahmad; El-Mougy, Fatma; El‐Karaksy, Hanaa; Hassanin, Fetouh; Helmy, Hanan

doi:10.4103/1319-3767.91738

Cited by 52 publications

(25 citation statements)

References 40 publications

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“…Obesity is strictly related to the development of fatty liver. In the present study, 75% of obese/overweight patients had ultrasound-detected fatty liver which is lower than El-Koofy and colleagues[24] who found it in 96.9% of their studied population. However, only 45% of their obese/overweight patients had biopsy-proven fatty liver.…”

Section: Discussioncontrasting

confidence: 77%

Skin tags: A link between lesional mast cell count/tryptase expression and obesity and dyslipidemia

Salem¹,

Attia

Osman³

et al. 2013

Indian J Dermatol

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Background:The etiology of skin tags (STs) is not fully understood. A relation to diabetes mellitus and obesity was suggested. Few studies of possible mast cells (MCs) involvement were reported. Tyrptase is a mast cell mediator and a potent fibroblast growth factor. It may provide a molecular link between mast cell activation and fibrosis.Aims:The aim was to assess clinical and laboratory findings in patients with STs, and the possible link between obesity, dyslipidemia, and lesional MC count/tryptase expression.Materials and Methods:A total of 20 patients with STs were subjected to clinical examination, estimation of body mass index (BMI), fasting blood glucose (FBG), postprandial blood glucose (PPBG), serum cholesterol and triglycerides, abdominal ultrasound for fatty liver assessment, in addition to study of MCs through staining for MC tryptase in two skin biopsies; lesional and nonlesional (control).Results:All patients showed abnormally high BMI and hypertriglyceridemia, with abnormal sonographic pattern in 15 patients (75%). STs number positively correlated with the age of patients. STs showed significantly higher MC counts and tryptase expression, compared with control skin (P < 0.001), with no correlation of the STs number or MC count with BMI, FBG, PPBG or serum cholesterol. Obese patients showed a significantly higher MC count than overweight and there was a positive correlation between MC count and serum triglycerides. Axilla and under breast STs showed a higher MC count compared with other sites.Conclusions:STs seem to be related to obesity and hypertriglyceridemia. MCs with their tryptase are possibly involved in pathogenesis of STs. MC count is related to the associated factors; obesity and serum triglycerides. MC tryptase expression is a reliable method for accurate tissue MC counting.

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Section: Discussioncontrasting

confidence: 77%

Skin tags: A link between lesional mast cell count/tryptase expression and obesity and dyslipidemia

Salem¹,

Attia

Osman³

et al. 2013

Indian J Dermatol

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“…In this last case, the increase in the relative liver weight may be the earlier symptom of a liver disorder; paediatric non-alcoholic fatty liver disease (NAFLD; Fishbein et al 2005Fishbein et al , 2006. Paediatric NAFLD is increasingly being detected in obese children and linked with metabolic syndrome and insulin resistance (Sundaram et al 2009); especially, in developing countries such as Brazil, China, Middle Eastern countries and India (Suano de Souza et al 2008, Meng et al 2011, El-Koofy et al 2012, Bramlage et al 2013. In any case, our current results are paving the way for further studies whereby swine, and specifically Iberian swine, serve as an amenable model.…”

Section: Discussionmentioning

confidence: 66%

Early-postnatal changes in adiposity and lipids profile by transgenerational developmental programming in swine with obesity/leptin resistance

González-Bulnes¹,

Astiz²,

Óvilo³

et al. 2014

Journal of Endocrinology

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Maternal malnutrition during pregnancy, both deficiency and excess, induces changes in the intrauterine environment and the metabolic status of the offspring, playing a key role in the growth, status of fitness/obesity and appearance of metabolic disorders during postnatal life. There is increasing evidence that these effects may not be only limited to the first generation of descendants, the offspring directly exposed to metabolic challenges, but to subsequent generations. This study evaluated, in a swine model of obesity/leptin resistance, the existence and extent of transgenerational developmental programming effects. Pre-and postnatal development, adiposity and metabolic features were assessed in the second generation of piglets, descendant of sows exposed to either undernutrition or overnutrition during pregnancy. The results indicated that these piglets exhibited early-postnatal increases in adiposity and disturbances in lipid profiles compatible with the early prodrome of metabolic syndrome, with liver tissue also displaying evidence of paediatric liver disease. These features indicative of early-life metabolic disorders were more evident in the males that were descended from overfed grandmothers and during the transition from milk to solid feeding. Thus, this study provides evidence supporting transgenerational developmental programming and supports the necessity for the development of strategies for avoiding the current epidemics of childhood overweight and obesity.

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“…Children with NAFLD often present with metabolic syndrome components, such as higher concentrations of cholesterol and triglyceride, and lower concentrations of HDL [26,27,28]. It is possible that respondents forgot if they had been told that they had one of these conditions when they were younger or had misunderstood the survey question, or that the condition might have resolved.…”

Section: Discussionmentioning

confidence: 99%

Natural History of NAFLD Diagnosed in Childhood: A Single-Center Study

et al. 2017

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Little is known regarding the subsequent course of non-alcoholic fatty liver disease (NAFLD) diagnosed in childhood. The objectives of this single-center study were to gather data on long-term health outcomes and to assess the feasibility of contacting former pediatric patients. In a large pediatric medical center, electronic records were searched to initially identify 162 former patients who had a liver biopsy between 2000 and 2010. Of these, 44 subjects met the criteria for age at follow-up (≥18 year) and biopsy-proven NAFLD, and were recruited via postal and electronic mail. Participants were invited to complete a brief telephone survey on current health status. Supplemental data was also obtained from pediatric medical charts of all subjects. At NAFLD diagnosis, 18% of subjects had diabetes, 91% were obese, 61% had NASH, and 56% had fibrosis on biopsy. At follow-up, 10 subjects (23%) responded to the survey. Based on the survey and chart review, after a mean follow-up of 4.5 years, 5 additional subjects developed diabetes for a period prevalence of 30%, and most subjects (78%) remained obese at last follow-up. Additional prospective studies are needed to fully describe the longitudinal risks associated with pediatric NAFLD, and will require multi-dimensional strategies to successfully recruit former patients.

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The association of metabolic syndrome, insulin resistance and non-alcoholic fatty liver disease in overweight/obese children

Cited by 52 publications

References 40 publications

Skin tags: A link between lesional mast cell count/tryptase expression and obesity and dyslipidemia

Skin tags: A link between lesional mast cell count/tryptase expression and obesity and dyslipidemia

Early-postnatal changes in adiposity and lipids profile by transgenerational developmental programming in swine with obesity/leptin resistance

Natural History of NAFLD Diagnosed in Childhood: A Single-Center Study

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