The Association of Microglial Activation and Amyloid Reduction in APP+PS1 Transgenic Mice

Morgan, Dave; Jantzen, Paul T.; Wilcock, Donna M.; DiCarlo, Giovanni; Ugen, Ken; Gordon, Marcia N.

doi:10.2174/1568013033358680

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Estrogen and Nf-κb Mediated In Ad1

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2019

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“…In the early stages of AD discovery, neuropathologists have recognized that glial cells proliferate significantly in the brains of AD patients [78]. Activation of microglia and astrocytes is also extensively present in the brain of AD transgenic mice [79,80]. In particular, there is obvious reactive hyperplasia of glial cells around the amyloid plaque.…”

Section: Estrogen and Nf-κb Mediated In Admentioning

confidence: 99%

Estrogen and Susceptibility of Alzheimer’s Disease

Shi

2019

CTBEB

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Estrogen is of great importance in regulating normal reproductive and non-reproductive functions. Aromatase is a key enzyme for the biosynthesis of estrogen in the body. The physiological roles of estrogen is mediated by estrogen receptors (ERs). When estrogen levels and/or the expression of its receptor protein are disrupted in the body, it can lead to diseases such as osteoporosis, and may increase susceptibility to diseases such as alzheimer's disease (AD). This paper reviews the relationship between estrogen and AD susceptibility.

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Section: Estrogen and Nf-κb Mediated In Admentioning

confidence: 99%

Estrogen and Susceptibility of Alzheimer’s Disease

Shi

2019

CTBEB

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show abstract

The Association of Microglial Activation and Amyloid Reduction in APP+PS1 Transgenic Mice

Cited by 1 publication

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Estrogen and Susceptibility of Alzheimer’s Disease

Estrogen and Susceptibility of Alzheimer’s Disease

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