The association of microtubules with tight junctions is promoted by cingulin phosphorylation by AMPK

Yano, Tomoki; Matsui, Toshimitsu; Tamura, Atsushi; Uji, Masami; Tsukita, Sachiko

doi:10.1083/jcb.201304194

Cited by 98 publications

(118 citation statements)

References 38 publications

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“…In this study, miR-125a was up-regulated at 2 h after PH, and CGN, PIGR, SIRT5 and TAP2 which showed down-regulated expression at 2 h and 6 h after PH were found to be the predicted targets of miR-125a. Cingulin (CGN) was involved in morphogenesis of epithelial cells through tight junction signaling (Yano et al, 2013). Polymeric immunoglobulin receptor (PIGR) was found to regulate cell proliferation (Ocak et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Integrative proteomic and microRNA analysis of the priming phase during rat liver regeneration

Geng

Chang

Zang

et al. 2016

Gene

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Section: Discussionmentioning

confidence: 99%

Integrative proteomic and microRNA analysis of the priming phase during rat liver regeneration

Geng

Chang

Zang

et al. 2016

Gene

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“…It clearly has both structural and signaling roles at the tight junction; for example, cingulin phosphorylation promotes the junctional association of microtubules [83]. Cingulin is also involved in the junction recruitment of GTPase regulatory proteins and in junction formation [84, 85].…”

Section: Core Components Of the Tight Junction: Integral Membrane mentioning

confidence: 99%

Architecture of tight junctions and principles of molecular composition

Itallie¹,

Anderson²

2014

Seminars in Cell & Developmental Biology

448

349

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The tight junction creates an intercellular barrier limiting paracellular movement of solutes and material across epithelia. Currently many proteins have been identified as components of the tight junction and understanding their architectural organization and interactions is critical to understanding the biology of the barrier. In general the architecture can be conceptualized into compartments with the transmembrane barrier proteins (claudins, occludin, JAM-A, etc.), linked to peripheral scaffolding proteins (such as ZO-1, afadin, MAGI1, etc.) which are in turned linked to actin and microtubules through numerous linkers (cingulin, myosins, protein 4.1, etc.). Within this complex network are associated many signaling proteins that affect the barrier and broader cell functions. The PDZ domain is a commonly used motif to specifically link individual junction protein pairs. Here we review some of the key proteins defining the tight junction and general themes of their organization with the perspective that much will be learned about function by characterizing the detailed architecture and subcompartments within the junction.

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“…Actin turnover and actomyosin contraction at the TJ also regulate TJ barrier function (Shen et al 2006). Additionally, microtubules associate with TJs through cingulin (Yano et al 2013). …”

Section: Introductionmentioning

confidence: 99%

Cell–Cell Junctions Organize Structural and Signaling Networks

García

Nelson

Chavez

2017

Cold Spring Harb Perspect Biol

360

253

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Cell-cell junctions link cells to each other in tissues, and regulate tissue homeostasis in critical cell processes that include tissue barrier function, cell proliferation and migration. Defects in cell-cell junctions give rise to a wide range of tissue abnormalities that disrupt homeostasis and are common in genetic abnormalities and cancers. Here, we discuss the organization and function of cell-cell junctions primarily involved in adhesion (Tight Junction, Adherens Junction, and Desmosomes) in two different epithelial tissues: a simple epithelium (intestine) and a stratified epithelium (epidermis). Studies in these tissues reveal similarities and differences in the organization and functions of different cell-cell junctions that meet the requirements for the specialized functions of each tissue. We discuss cell-cell junction responses to genetic and environmental perturbations that provide further insights into their roles in maintaining tissue homeostasis.

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The association of microtubules with tight junctions is promoted by cingulin phosphorylation by AMPK

Abstract: Cingulin phosphorylation by AMPK promotes its binding to α-tubulin and is required for the association of planar apical microtubules with epithelial tight junctions.

Cited by 98 publications

References 38 publications

Integrative proteomic and microRNA analysis of the priming phase during rat liver regeneration

Integrative proteomic and microRNA analysis of the priming phase during rat liver regeneration

Architecture of tight junctions and principles of molecular composition

Cell–Cell Junctions Organize Structural and Signaling Networks

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