The association of MMP-9 and IL-18 gene promoter polymorphisms with gingivitis in adolescents

Vokurka, Jan; Klapušová, Lucie; Pantuckova, Pavla; Kukletová, Martina; Kukla, Lubomír; Hollá, Lýdie Izakovičová

doi:10.1016/j.archoralbio.2008.09.002

Cited by 19 publications

(16 citation statements)

References 44 publications

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“…Pediatric, anthropological and psychological examinations have already taken place in the 8th, 11th, 13th and 15th years of the subjects' lives. These ages were chosen in order to record developmental and health changes associated with the prepubertal, pubertal and postpubertal phases of child development [Vokurka et al, 2009]. In addition, children participating in this study underwent a dental examination at the Clinic of Stomatology, St. Anne's University Hospital, and the Faculty of Medicine, Masaryk University.…”

Section: Subjectsmentioning

confidence: 99%

Lack of Association between Lactotransferrin Polymorphism and Dental Caries

et al. 2013

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Objective: Dental caries is a complex, multifactorial disease and one of the most common illnesses worldwide. Its etiology is related to microbial, dietary and host factors. Recent evidence suggests a role of lactotransferrin (LTF) in caries. The purpose of this study was to determine the association between LTF gene polymorphism and dental caries. Methods: In this case-control study, 637 unrelated children, aged 11-13 years, were enrolled. The subjects were divided into two groups, i.e. caries-free (decayed/missing/filled teeth = 0) and caries-affected children (decayed/missing/filled teeth ≥ 1). The LTF rs1126478 (140A/G in exon 2, Lys/Arg) genotypes were determined by PCR with restriction analysis using the EarI enzyme. Results: Of 637 children, 155 (24.3%) were caries free. There were no statistically significant differences between caries levels and allele or genotype distributions in the total cohort. When the caries-affected group (n = 482) was stratified into low (decayed/missing/filled teeth = 1), moderate (2 ≤ decayed/missing/filled teeth ≤ 3) and high (decayed/missing/filled teeth ≥ 4) caries experience, allele and genotype frequencies were similar among all subgroups. Conclusions: The LTF 140A/G (exon 2, Lys/Arg) polymorphism was not associated with the susceptibility to or severity of dental caries in the Czech population.

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Section: Subjectsmentioning

confidence: 99%

Lack of Association between Lactotransferrin Polymorphism and Dental Caries

et al. 2013

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“…Studies have consistently supported the correlation of MMP-9 rs3918242 polymorphism correlated with increased susceptibility to a variety of diseases [19–21], including coronary artery diseases [22]. The previous study also revealed that MMP-9 rs3918242 polymorphism was associated with the susceptibility to acute coronary syndrome (ACS) in the Uygur population of China [23].…”

Section: Discussionmentioning

confidence: 91%

Impact of matrix metalloproteinase 9 rs3918242 genetic variant on lipid-lowering efficacy of simvastatin therapy in Chinese patients with coronary heart disease

Wang

Zhi

et al. 2017

BMC Pharmacol Toxicol

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BackgroundGenetic variation of matrix metalloproteinase 9 (MMP-9) gene polymorphism has been suggested to modulate coronary heart diseases (CHD), yet the underlying mechanisms are not well understood.MethodsWe investigated the association of MMP9 rs3918242 single nucleotide polymorphism with inflammation and lipid-lowering efficacy after simvastatin treatment in Chinese patients with CHD. Fasting serum lipid profile and plasma inflammatory mediators were determined at baseline in 264 patients with CHD and 186 healthy control subjects, and after HMG-CoA reductase inhibitor simvastatin treatment (20 mg/day) for 12 weeks in CHD subjects.ResultsWe found that plasma MMP-9, TNF-α and IL-10 levels were significantly elevated in patients with CHD compared to control subjects before treatment. The plasma MMP9 in CHD patients carrying rs3918242 CC, CT and TT genotypes were comparable. Interestingly, CHD patients carrying TT genotype had significantly higher level of triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) than those carrying CC genotype (P <0.05). Simvastatin treatment significantly reduced LDL-C, TG and plasma inflammatory mediator levels in CHD patients. The reduction of LDL-C upon simvastatin therapy was significantly greater in patients carrying TT genotype than those carrying CC genotype (P <0.05).ConclusionsMMP9 rs3918242 TT genotype is associated with elevated serum TG and LDL-C, and enhanced LDL-C-lowering response upon simvastatin treatment in Chinese patients with CHD.Clinical trial registrationThis study was retrospectively registered at Chinese Clinical Trial Registry (Registration number: ChiCTR-ROC-17010971) on March 23rd 2017.

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“…Given the multifactorial nature of inflammation and the major role of IL-18 in modulating immune functions, the possible association of polymorphisms in the IL-18 gene with plaque-induced gingivitis has been investigated. Previously we demonstrated no significant association of IL-18 -607A/C variant within the IL-18 gene with gingivitis (Vokurka et al, 2009). In a much larger (twice as large) study, we screened three IL-18 SNPs (at positions -607A/C, -137C/G, and -133C/G) alone and in combination (i.g.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with combined genotype CT (of MMP-9 -1562C/T) and CC (of IL18 -607A/C) had 5.6 times higher risk of the gingivitis development compared to persons without this genotype (Vokurka et al, 2009). Although the matrix metalloproteinase genes seem good candidates for their association with periodontal inflammation and destruction, investigations have not yet yielded sufficient data for conclusions about the role of these genes in plaque-induced gingivitis.…”

Section: Polymorphisms In the Mmp-9 Genementioning

confidence: 99%

“…There are only three studies of the IL-18 gene polymorphisms in chronic periodontitis (Folwaczny et al, 2005, Noack et al, 2008). Only one previous study on the potential association between IL-18 -607A/C variant and risk of gingivitis has been published so far by our group (Vokurka et al, 2009). With respect to the key role of interleukins in inflammatory response in gingivitis, the IL-18 gene is an obvious functional candidate for this disease.…”

Section: Introductionmentioning

confidence: 99%

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