The association of mucocutaneous lichen planus and chronic liver disease

Strauss, Robert A.; Fattore, LaDeane; Soltani, Keyoumars

doi:10.1016/0030-4220(89)90137-0

Cited by 39 publications

(17 citation statements)

References 20 publications

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“…Interface dermatitis with premature terminal differentiation: 80% cases of LP had lesions localised to the flexor aspect of extremities, a finding similar to Boyd et al 3 Oral lesions were present in 16.9% cases while a higher incidence (65%) was reported in classical cutaneous LP by Strauss etal. 10 Arndt K. A 11 reported genital involvement in 25% of men with typical skin lesions which was not seen in our study. Altman J 9 reported nail involvement in 1-16% of patients.…”

Section: Clinical Correlation With the Type Of Interface Dermatitiscontrasting

confidence: 63%

A Study of Interface Dermatitis With Clinical Correlation

Kumar¹,

Nandakumar²

2015

jemds

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BACKGROUND:Interface dermatitis (ID) is defined as an inflammatory skin disease in which the junction between the papillary dermis and the epidermis is obscured. They are so named because they are cell mediated immune reactions whose targets are basal keratinocytes that reside above the dermo-epidermal junction. Interface dermatitis encompasses multiple clinical entities with diverse histological features. This study is aimed at understanding the various associated histological features with clinical correlation of conditions in which Interface Dermatitis is the most important histopathologic finding. This will help us in arriving at a more specific diagnosis by light microscopy. MATERIALS AND METHODS:The study was conducted over a period of two and a half years. Skin biopsies showing interface dermatitis as a major histological finding were studied in detail and classified according to Le Boit's classification. PAS staining was done to highlight pathology of basement membrane. Normal skin biopsies & biopsies with an unrelated condition were taken as control. Correlation between clinical features, clinical diagnosis and histological diagnosis was assessed. RESULTS: 71 cases showing interface dermatitis were studied. The most common age range was between 50-59 years with a female preponderance. Majority of the cases belonged to type I interface dermatitis with lichen planus being representative of this type. PAS staining revealed basement membrane disruption in many of the cases. CONCLUSION: Interface dermatitis includes diverse entities which have overlapping features at the clinical and histopathological level. Hence, a detailed light microscopic examination aided further by special tests such as immunofluorescence will help at arriving at a definitive diagnosis. More studies are also needed in order to identify specific features to redefine each of the entities.

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Section: Clinical Correlation With the Type Of Interface Dermatitiscontrasting

confidence: 63%

A Study of Interface Dermatitis With Clinical Correlation

Kumar¹,

Nandakumar²

2015

jemds

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“…Mucosal lesions include oral and genital lesions and are less common in men. Oral lesions occur as the only symptom of LP in 15–35% of patients but up to 65% of patients with classic cutaneous disease have oral involvement 1 . There are very few studies in the literature assessing the prevalence of vulval LP, but it is probably more common than previously thought.…”

Section: Introductionmentioning

confidence: 99%

Mucosal (oral and vulval) lichen planus in women: are angiotensin-converting enzyme inhibitors protective, and beta-blockers and non-steroidal anti-inflammatory drugs associated with the condition?

Clayton

Chaudhry

Ali

et al. 2010

Clinical and Experimental Dermatology

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“…Boyd and Neldner (10) reported that the incidence of hepatitis in patients with lichen planus varied from 9.5% to 13.5%. Strauss et al (23) suggested that the most common liver ailments associated with lichen planus are chronic active hepatitis and primary biliary cirrhosis, and also proposed that administration of D-penicillamine may predispose a patient with primary biliary cirrhosis to the development of lichen planus as well as aggravating any existing disease. Al-Khenaizan (24) reported a case of lichen planus occurring after hepatitis B vaccination.…”

Section: Discussionmentioning

confidence: 99%