The Association of Neutrophil–Lymphocyte Ratio with Venous Thromboembolism:  A Systematic Review and Meta-Analysis

Hu, Jingjing; Cai, Zhaobin; Zhou, Yuanfei

doi:10.1177/10760296221130061

Cited by 8 publications

(8 citation statements)

References 40 publications

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“…Plasma guanosine levels of plasma citrullinated histone H3, a biomarker of NET formation, are associated with VTE in patients with pancreatic cancer (PC). Elevated neutrophil count is a non-specific biomarker of inflammation [ 27 ]. A multicentre retrospective study [ 28 ] showed that postoperative intraperitoneal infection increased the risk of Splanchnic vein thrombosis (SVT).…”

Section: Discussionmentioning

confidence: 99%

Risk factor analysis and a new prediction model of venous thromboembolism after pancreaticoduodenectomy

2023

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Aim The present study aimed to identify risk factors for venous thromboembolism (VTE) after pancreaticoduodenectomy (PD) and to develop and internally validate a predictive model for the risk of venous thrombosis. Methods We retrospectively collected data from 352 patients who visited our hospital to undergo PD from January 2018 to March 2022. The number of patients recruited was divided in an 8:2 ratio by using the random split method, with 80% of the patients serving as the training set and 20% as the validation set. The least absolute shrinkage and selection operator (Lasso) regression model was used to optimize feature selection for the VTE risk model. Multivariate logistic regression analysis was used to construct a prediction model by incorporating the features selected in the Lasso model. C-index, receiver operating characteristic curve, calibration plot, and decision curve were used to assess the accuracy of the model, to calibrate the model, and to determine the clinical usefulness of the model. Finally, we evaluated the prediction model for internal validation. Results The predictors included in the prediction nomogram were sex, age, gastrointestinal symptoms, hypertension, diabetes, operative method, intraoperative bleeding, blood transfusion, neutrophil count, prothrombin time (PT), activated partial thromboplastin time (APTT), aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AST/ALT), and total bilirubin (TBIL). The model showed good discrimination with a C-index of 0.827, had good consistency based on the calibration curve, and had an area under the ROC curve value of 0.822 (P < 0.001, 95%confidence interval:0.761–0.882). A high C-index value of 0.894 was reached in internal validation. Decision curve analysis showed that the VTE nomogram was clinically useful when intervention was decided at the VTE possibility threshold of 10%. Conclusion The novel model developed in this study is highly targeted and enables personalized assessment of VTE occurrence in patients who undergo PD. The predictors are easily accessible and facilitate the assessment of patients by clinical practitioners.

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Section: Discussionmentioning

confidence: 99%

Risk factor analysis and a new prediction model of venous thromboembolism after pancreaticoduodenectomy

2023

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“…21 In contrast, Rinaldi et al and Hu et al found that a high NLR can be considered a diagnostic marker for VTE. 22,29 Additionally, Farah et al claimed that a high NLR could be a predictor of acute VTE. 30 indicated that a high NLR can increase the risk of VTE.…”

Section: Discussionmentioning

confidence: 99%

“…found that a high NLR can be considered a diagnostic marker for VTE. 22,29 Additionally, Farah et al. claimed that a high NLR could be a predictor of acute VTE.…”

Section: Discussionmentioning

confidence: 99%

Association of the neutrophil-to-lymphocyte ratio with the occurrence of venous thromboembolism and arterial thrombosis

Nguyen,

Vu,

Nguyen

et al. 2024

J Int Med Res

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Objective This study aimed to assess the association of the neutrophil-to-lymphocyte ratio (NLR) with the occurrence of venous thromboembolism (VTE) and arterial thrombosis (AT). Methods This was a retrospective cross-sectional study including 585 medical records obtained from all consecutive patients who were suspected of having thrombosis. Results The AT group had a higher neutrophil count and NLR and a lower lymphocyte count than the non-thrombosis group. Receiver operating characteristic curve analysis showed the ability of the NLR to predict the presence of AT. The cut-off value for the NLR was 4.44. No distinction was found in the NLR between the VTE and non-thrombosis groups. Regression analysis showed that a high NLR was an independent factor related to the presence of AT. Patients with an NLR ≥ 4.44 had a higher risk of AT than those with an NLR < 4.44 (odds ratio = 2.015, 95% confidence interval: 1.180–3.443). Conclusion A high NLR may be considered a predictive factor for the occurrence of AT, but an association with the presence of VTE was not found.

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“…P-LCR is the percentage of all platelets with a volume greater than 12 fL in the bloodstream and appears to be more sensitive to changes in platelet size than MPV. 5 , 31 This parameter which has not been adequately researched about PE, may guide the diagnosis of PE.…”

Section: Discussionmentioning

confidence: 99%

“…Potential inflammatory biomarkers in the hemogram can guide as useful markers both for explaining the pathogenesis of thrombosis and for diagnosis in PE. 4 – 6 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of Hemogram Parameters in the Diagnosis of Pulmonary Embolism: Immature Granulocytes and Other New Tips

Karakurt,

Guven,

Aynaci

et al. 2024

Clin Appl Thromb Hemost

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Pulmonary embolism (PE) is an important cause of sudden death and is difficult to diagnose. Therefore unnecessary radiological investigations are often resorted to. Although some inflammatory parameters in the hemogram have been found to play a role in the diagnosis of PE, many parameters have not been adequately investigated. We aimed to evaluate potential inflammatory parameters in hemogram in the diagnosis of PE and to determine the parameters with the highest diagnostic value. This single-center, retrospective study was performed by evaluating 114 cases with suspected PE admitted to the emergency department between January 2017 and June 2022. Among 114 cases, 62 cases with a definitive diagnosis of PE by pulmonary computed tomography angiography served as the PE group and 52 cases without PE served as the control group. Admission hemogram parameters of both groups were recorded. Potential chronic diseases and acute conditions affecting hemogram were excluded from the study. In the multivariate model; immature granulocyte (IG), neutrophil/lymphocyte ratio (NLR), monocyte % and platelet large cell ratio (P-LCR) were found to be significantly and independently effective in differentiating cases with and without PE ( P˂.05). Our findings suggest that high IG, high NLR, high monocyte %, and low P-LCR values have diagnostic value in cases with suspected PE. However the usability of IGs in the diagnosis of PE is a new finding. Hemogram is cheap, easily accessible, and potential inflammatory biomarkers in hemograms may increase physicians’ awareness in the diagnosis of PE.

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The Association of Neutrophil–Lymphocyte Ratio with Venous Thromboembolism: A Systematic Review and Meta-Analysis

Cited by 8 publications

References 40 publications

Risk factor analysis and a new prediction model of venous thromboembolism after pancreaticoduodenectomy

Risk factor analysis and a new prediction model of venous thromboembolism after pancreaticoduodenectomy

Association of the neutrophil-to-lymphocyte ratio with the occurrence of venous thromboembolism and arterial thrombosis

Evaluation of Hemogram Parameters in the Diagnosis of Pulmonary Embolism: Immature Granulocytes and Other New Tips

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